Ceramides and their roles in programmed cell death.
Anoikis
Apoptosis
Autophagy
Ceramide
Mitophagy
Necroptosis
Journal
Advances in medical sciences
ISSN: 1898-4002
Titre abrégé: Adv Med Sci
Pays: Netherlands
ID NLM: 101276222
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
07
03
2023
revised:
14
08
2023
accepted:
13
10
2023
medline:
27
11
2023
pubmed:
23
10
2023
entrez:
22
10
2023
Statut:
ppublish
Résumé
Programmed cell death plays a crucial role in maintaining the homeostasis and integrity of multicellular organisms, and its dysregulation contributes to the pathogenesis of many diseases. Programmed cell death is regulated by a range of macromolecules and low-molecular messengers, including ceramides. Endogenous ceramides have different functions, that are influenced by their localization and the presence of their target molecules. This article provides an overview of the current understanding of ceramides and their impact on various types of programmed cell death, including apoptosis, anoikis, macroautophagy and mitophagy, and necroptosis. Moreover, it highlights the emergence of dihydroceramides as a new class of bioactive sphingolipids and their downstream targets as well as their future roles in cancer cell growth, drug resistance and tumor metastasis.
Identifiants
pubmed: 37866204
pii: S1896-1126(23)00044-5
doi: 10.1016/j.advms.2023.10.004
pii:
doi:
Substances chimiques
Ceramides
0
Sphingolipids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
417-425Informations de copyright
Copyright © 2023 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interests.