ZnO/chitosan nanocomposites as a new approach for delivery LL37 and evaluation of the inhibitory effects against biofilm-producing Methicillin-resistant Staphylococcus aureus isolated from clinical samples.

Chitosan / chemistry Methicillin-Resistant Staphylococcus aureus Zinc Oxide / pharmacology Anti-Bacterial Agents / pharmacology Nanocomposites / chemistry Biofilms Peptides / pharmacology Microbial Sensitivity Tests
Antibacterial Biofilm LL37 chitosan/ZnO nanocomposite Methicillin-resistant Staphylococcus aureus

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
31 Dec 2023
Historique:
received: 20 05 2023
revised: 12 10 2023
accepted: 19 10 2023
medline: 24 11 2023
pubmed: 23 10 2023
entrez: 22 10 2023
Statut: ppublish

Résumé

Modification surface of chitosan nanoparticles using ZnO nanoparticles is important interest in drug delivery because of the beneficial properties. In this study, we proposed a chitosan/ZnO nanocomposite for the targeted delivery of antibacterial peptide (LL37). Synthesized LL37-loaded chitosan/ZnO nanocomposite (CS/ZnO/LL37-NCs) was based on the ionotropic gelation method. The antibacterial activity of the synthesized platform versus Methicillin-resistant Staphylococcus aureus (MRSA) was determined by the microdilution method in 10 mM sodium phosphate buffer. The biofilm formation inhibitory was also evaluated using microtiter plate method. In addition, the ability of CS/ZnO/LL37-NCs on the icaA gene expression level was assessed by the Real-Time PCR. The loading and release investigations confirmed the suitability of CS/ZnO-NCs for LL37 encapsulation. Results showed 6 log

Identifiants

DOI: 10.1016/j.ijbiomac.2023.127583 PMID: 37866577
pubmed: 37866577
pii: S0141-8130(23)04481-1
doi: 10.1016/j.ijbiomac.2023.127583
pii:
doi:

Substances chimiques

Chitosan 9012-76-4
Zinc Oxide SOI2LOH54Z
Anti-Bacterial Agents 0
Peptides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

127583

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Somaye Rashki (S)

Department of Microbiology, Faculty of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran.

Elmuez A Dawi (EA)

College of Humanities and Sciences, Department of Mathematics, and Science, Ajman University, P.O. Box 346, Ajman, UAE. Electronic address: e.dawi@ajman.ac.ae.

Mohammad Reza Zilaei (MR)

Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.

Hossein Safardoust-Hojaghan (H)

Institute of Nano Science and Nano Technology, University of Kashan, P.O. Box 87317-51167, Kashan, Iran.

Mojgan Ghanbari (M)

Institute of Nano Science and Nano Technology, University of Kashan, P.O. Box 87317-51167, Kashan, Iran.

Abrar Ryadh (A)

Medical Laboratory Techniques Department, College of Techniques, Al-Mustaqbal University, 51001 Hillah, Iraq.

Holya A Lafta (HA)

Medical Laboratory Techniques Department, Al-Nisour University College, Baghdad, Iraq.

Azad Khaledi (A)

Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.

Masoud Salavati-Niasari (M)

Institute of Nano Science and Nano Technology, University of Kashan, P.O. Box 87317-51167, Kashan, Iran. Electronic address: salavati@kashanu.ac.ir.

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Classifications MeSH

questionsmedicales.fr › Glucides › Polyosides › Chitine › Chitosane › ZnO/chitosan nanocomposites as a new approach...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › ZnO/chitosan nanocomposites as a new approach...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du zinc › Oxyde de zinc › ZnO/chitosan nanocomposites as a new approach...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › ZnO/chitosan nanocomposites as a new approach...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanocomposites › ZnO/chitosan nanocomposites as a new approach...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › ZnO/chitosan nanocomposites as a new approach...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › ZnO/chitosan nanocomposites as a new approach...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › ZnO/chitosan nanocomposites as a new approach...