Probing Conformational Transition of TRPV5 Induced by Mechanical Force Using Coarse-Grained Molecular Dynamics.

Molecular Dynamics Simulation Calcium / metabolism Molecular Conformation Calcium Channels / chemistry TRPV Cation Channels

Journal

Journal of chemical information and modeling
ISSN: 1549-960X
Titre abrégé: J Chem Inf Model
Pays: United States
ID NLM: 101230060

Informations de publication

Date de publication:
13 11 2023
Historique:
medline: 14 11 2023
pubmed: 23 10 2023
entrez: 23 10 2023
Statut: ppublish

Résumé

Transient receptor potential vanilloid 5 (TRPV5) is a calcium-selective TRP channel that plays a crucial role in calcium homeostasis regulation. However, there are still many issues that need to be addressed, such as the specific conformational transition of TRPV5 and the specific functions of each structure in cation gating. Here, we build a model of the calcium ion transport protein from

Identifiants

DOI: 10.1021/acs.jcim.3c00614 PMID: 37871325
pubmed: 37871325
doi: 10.1021/acs.jcim.3c00614
doi:

Substances chimiques

Calcium SY7Q814VUP
Calcium Channels 0
TRPV Cation Channels 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6768-6777

Auteurs

Yinwei Gu (Y)

State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210009, China.

Yan Li (Y)

State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210009, China.
ORCID: 0000-0002-0184-8439

Baocai Ma (B)

State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210009, China.

Ke Ren (K)

Department of Orthopaedics, Zhongda Hospital, Southeast University, Nanjing 210009, China.

Chen Cao (C)

School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China.

Ning Gu (N)

State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210009, China.
Medical School, Nanjing University, Nanjing 210093, China.
ORCID: 0000-0003-0047-337X

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Probing Conformational Transition of TRPV5...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Probing Conformational Transition of TRPV5...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Probing Conformational Transition of TRPV5...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Probing Conformational Transition of TRPV5...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › Probing Conformational Transition of TRPV5...