A comprehensive evaluation of arginine and its derivatives as protein formulation stabilizers.
Acetyl arginine
Arginine
Arginine ethyl ester
Protein aggregation
Subvisible particle
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Nov 2023
25 Nov 2023
Historique:
received:
07
07
2023
revised:
14
10
2023
accepted:
21
10
2023
medline:
20
11
2023
pubmed:
24
10
2023
entrez:
23
10
2023
Statut:
ppublish
Résumé
Arginine and its derivatives (such as arginine ethyl ester and acetyl arginine) have varying degrees of protein aggregation suppressor effect across different protein solutions. To understand this performance ambiguity, we evaluated the activity of arginine, acetyl arginine, and arginine ethyl ester for aggregation suppressor effect against human intravenous immunoglobulin G (IgG) solution at pH 4.8. Both arginine and its cationic derivative arginine ethyl ester in their hydrochloride salt forms significantly reduced the colloidal and conformational stability (reduced k
Identifiants
pubmed: 37871869
pii: S0378-5173(23)00966-3
doi: 10.1016/j.ijpharm.2023.123545
pii:
doi:
Substances chimiques
Protein Aggregates
0
Immunoglobulin G
0
Arginine
94ZLA3W45F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123545Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.