A non-canonical striatopallidal Go pathway that supports motor control.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
23 10 2023
23 10 2023
Historique:
received:
28
01
2023
accepted:
05
10
2023
medline:
27
10
2023
pubmed:
24
10
2023
entrez:
23
10
2023
Statut:
epublish
Résumé
In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent studies have re-established that dSPNs also possess axon collaterals within the globus pallidus (GPe) (bridging collaterals), yet the significance of these collaterals for behavior is unknown. Here we use in vivo optical and chemogenetic tools combined with deep learning approaches in mice to dissect the roles of dSPN GPe collaterals in motor function. We find that dSPNs projecting to the SNr send synchronous motor-related information to the GPe via axon collaterals. Inhibition of native activity in dSPN GPe terminals impairs motor activity and function via regulation of Npas1 neurons. We propose a model by which dSPN GPe axon collaterals (striatopallidal Go pathway) act in concert with the canonical terminals in the SNr to support motor control by inhibiting Npas1 neurons.
Identifiants
pubmed: 37872145
doi: 10.1038/s41467-023-42288-1
pii: 10.1038/s41467-023-42288-1
pmc: PMC10593790
doi:
Substances chimiques
Npas1 protein, mouse
0
Nerve Tissue Proteins
0
Basic Helix-Loop-Helix Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6712Subventions
Organisme : NIMH NIH HHS
ID : T32 MH018870
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH093672
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DA000069
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS069777
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH124858
Pays : United States
Organisme : NINDS NIH HHS
ID : R56 NS069777
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023. Springer Nature Limited.
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