Tuberculosis Variant with Rifampin Resistance Undetectable by Xpert MTB/RIF, Botswana.
Botswana
antimicrobial resistance
bacteria
molecular diagnostics
molecular epidemiology
multidrug-resistant tuberculosis
pre–XDR TB
respiratory infections
rifampin resistance
tuberculosis and other mycobacteria
whole-genome sequencing
Journal
Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
medline:
26
10
2023
pubmed:
25
10
2023
entrez:
25
10
2023
Statut:
ppublish
Résumé
GeneXpert MTB/RIF, a tool widely used for diagnosing tuberculosis, has limitations for detecting rifampin resistance in certain variants. We report transmission of a pre-extensively drug-resistant variant in Botswana that went undetected by GeneXpert. The public health impact of misdiagnosis emphasizes the need for comprehensive molecular testing to identify resistance and guide treatment.
Identifiants
pubmed: 37877680
doi: 10.3201/eid2911.230987
pmc: PMC10617350
doi:
Substances chimiques
Rifampin
VJT6J7R4TR
Antibiotics, Antitubercular
0
Types de publication
Letter
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2403-2406Subventions
Organisme : NIAID NIH HHS
ID : R01 AI097045
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI147336
Pays : United States
Références
Emerg Infect Dis. 2021 Mar;27(3):835-844
pubmed: 33622470
BMJ Glob Health. 2023 May;8(5):
pubmed: 37230547
Genome Med. 2020 Nov 25;12(1):104
pubmed: 33239092
Lancet. 2022 Aug 13;400(10351):480-481
pubmed: 35964598
Mol Biol Evol. 2015 Jan;32(1):268-74
pubmed: 25371430
Lancet Infect Dis. 2018 Dec;18(12):1350-1359
pubmed: 30342828
Future Microbiol. 2011 Sep;6(9):1067-82
pubmed: 21958145
PeerJ. 2018 Nov 13;6:e5895
pubmed: 30479891
N Engl J Med. 2015 Mar 19;372(12):1181-2
pubmed: 25785984