Fabrication and

Humans Polyvinyl Alcohol / chemistry Diclofenac Cross-Linking Reagents / chemistry Drug Delivery Systems Hydrogels / chemistry Hydrogen-Ion Concentration Drug Liberation
diclofenac sodium. drug release pH-sensitive hydrogels porosity swelling toxicity

Journal

Current pharmaceutical design
ISSN: 1873-4286
Titre abrégé: Curr Pharm Des
Pays: United Arab Emirates
ID NLM: 9602487

Informations de publication

Date de publication:
2023
Historique:
received: 20 06 2023
accepted: 25 09 2023
medline: 23 11 2023
pubmed: 26 10 2023
entrez: 26 10 2023
Statut: ppublish

Résumé

Diclofenac sodium has a short half-life (about 1.5 hours), requiring repeated administration, and as a result, serious complications, such as GI bleeding, peptic ulcer, and kidney and liver dysfunction, are generated. Hence, a sustained/controlled drug delivery system is needed to overcome the complications caused by the administration of diclofenac sodium. This study aimed to fabricate and evaluate carbopol/polyvinyl alcohol-based pH-sensitive hydrogels for controlled drug delivery. pH-sensitive carbopol/polyvinyl alcohol graft-poly(acrylic acid) hydrogels (Cp/PVA-g-PAa hydrogels) were developed for the controlled delivery of diclofenac sodium. The combination of carbopol/polyvinyl alcohol, acrylic acid, and ethylene glycol dimethacrylate was used as polymer, monomer, and cross-linker, respectively. The effects of the formulation's composition on porosity, swelling index, and release pattern of diclofenac sodium from the developed hydrogels were investigated. An increase in porosity and swelling was observed with the increasing amounts of carbopol and acrylic acid, whereas polyvinyl alcohol showed the opposite effect. Due to the formation of a highly viscous system, the drug release decreased with the increasing concentrations of carbopol and polyvinyl alcohol while increased with increasing acrylic acid concentration. The pH-responsive properties of the fabricated hydrogels were demonstrated by dynamic swelling and drug release studies at three different pH values. Higher dynamic swelling and diclofenac sodium (model drug) release were found at high pH values compared to low pH values, The prepared carbopol/polyvinyl alcohol crosslinked hydrogel can be used as a promising carrier for the controlled release of drugs.

Sections du résumé

BACKGROUND BACKGROUND
Diclofenac sodium has a short half-life (about 1.5 hours), requiring repeated administration, and as a result, serious complications, such as GI bleeding, peptic ulcer, and kidney and liver dysfunction, are generated. Hence, a sustained/controlled drug delivery system is needed to overcome the complications caused by the administration of diclofenac sodium.
AIMS OBJECTIVE
This study aimed to fabricate and evaluate carbopol/polyvinyl alcohol-based pH-sensitive hydrogels for controlled drug delivery.
OBJECTIVE OBJECTIVE
pH-sensitive carbopol/polyvinyl alcohol graft-poly(acrylic acid) hydrogels (Cp/PVA-g-PAa hydrogels) were developed for the controlled delivery of diclofenac sodium.
METHODS METHODS
The combination of carbopol/polyvinyl alcohol, acrylic acid, and ethylene glycol dimethacrylate was used as polymer, monomer, and cross-linker, respectively. The effects of the formulation's composition on porosity, swelling index, and release pattern of diclofenac sodium from the developed hydrogels were investigated.
RESULTS RESULTS
An increase in porosity and swelling was observed with the increasing amounts of carbopol and acrylic acid, whereas polyvinyl alcohol showed the opposite effect. Due to the formation of a highly viscous system, the drug release decreased with the increasing concentrations of carbopol and polyvinyl alcohol while increased with increasing acrylic acid concentration. The pH-responsive properties of the fabricated hydrogels were demonstrated by dynamic swelling and drug release studies at three different pH values. Higher dynamic swelling and diclofenac sodium (model drug) release were found at high pH values compared to low pH values,
CONCLUSION CONCLUSIONS
The prepared carbopol/polyvinyl alcohol crosslinked hydrogel can be used as a promising carrier for the controlled release of drugs.

Identifiants

DOI: 10.2174/0113816128268132231016061548 PMID: 37881070
pubmed: 37881070
pii: CPD-EPUB-135402
doi: 10.2174/0113816128268132231016061548
doi:

Substances chimiques

polyvinyl alcohol hydrogel 0
Polyvinyl Alcohol 9002-89-5
acrylic acid J94PBK7X8S
carboxypolymethylene 0A5MM307FC
Diclofenac 144O8QL0L1
Cross-Linking Reagents 0
Hydrogels 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2489-2500

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Auteurs

Muhammad Suhail (M)

School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

I-Hui Chiu (IH)

School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Jia-Yu Liu (JY)

School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Hamid Ullah (H)

School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

I-Ling Lin (IL)

Department of Medicine Laboratory Science and Biotechnology, College of Health Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.

Muhammad Usman Minhas (MU)

College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.

Ming-Jun Tsai (MJ)

School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
School of Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.
Department of Neurology, China Medical University Hospital, Taichung 404, Taiwan.
Department of Neurology, An-Nan Hospital, China Medical University, Tainan 709, Taiwan.

Pao-Chu Wu (PC)

School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fabrication and
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Polyvinyles › Poly(alcool vinylique) › Fabrication and
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Phénylacétates › Diclofenac › Fabrication and
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Réactifs réticulants › Fabrication and
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Fabrication and
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Fabrication and
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Fabrication and
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Fabrication and