Body mass index-dependent immunological profile changes after left ventricular assist device implantation.
body mass index
dendritic cells
immune system
left ventricular assist device
obesity
regulatory T cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
07
2023
accepted:
25
09
2023
medline:
30
10
2023
pubmed:
27
10
2023
entrez:
27
10
2023
Statut:
epublish
Résumé
Infection is a common complication following left ventricular assist device (LVAD) implantation. Patients with obesity are particularly at risk due to their high percentage of adipose tissue and the resulting chronic inflammatory state and resulting immunological changes. This study investigated changes of immunological parameters in relation to body mass index (BMI) during the first year after LVAD implantation. Blood samples were obtained prior to LVAD implantation and at 3 (1 After LVAD implantation, obese patients (0.51 ± 0.20%) showed a higher proportion of overall DCs than normal-weight (0.28 ± 0.10%) and pre-obese patients (0.32 ± 0.11%, p<0.01) at 3 This study reported changes of the innate and adaptive immune system of pre-obese and obese compared to normal-weight patients one year after LVAD implantation. DCs and their subsets, CD8
Identifiants
pubmed: 37885885
doi: 10.3389/fimmu.2023.1256725
pmc: PMC10597783
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1256725Informations de copyright
Copyright © 2023 Klaeske, Messer, Klein, Sieg, Eifert, Haunschild, Jawad, Saeed, Dashkevich, Borger and Dieterlen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Hum Vaccin Immunother. 2014;10(11):3224-35
pubmed: 25483675
J Immunol Res. 2019 Sep 2;2019:2164017
pubmed: 31565659
Open Forum Infect Dis. 2020 Apr 17;7(5):ofaa124
pubmed: 32405511
J Heart Lung Transplant. 2011 Apr;30(4):375-84
pubmed: 21419995
Obes Facts. 2023;16(4):364-373
pubmed: 37232004
ASAIO J. 2017 Mar/Apr;63(2):128-133
pubmed: 27922883
Immune Netw. 2022 Feb 07;22(1):e13
pubmed: 35291655
Proc Nutr Soc. 2012 May;71(2):298-306
pubmed: 22414338
ASAIO J. 2010 Jan-Feb;56(1):57-60
pubmed: 20051832
Circulation. 2014 May 27;129(21):2111-24
pubmed: 24657994
Front Immunol. 2018 Nov 15;9:2651
pubmed: 30498496
Int J Mol Sci. 2021 Aug 12;22(16):
pubmed: 34445379
J Heart Lung Transplant. 2020 Aug;39(8):774-781
pubmed: 32276809
J Thromb Haemost. 2021 May;19(5):1331-1341
pubmed: 33636040
Ann Thorac Surg. 2008 May;85(5):1656-61
pubmed: 18442560
Int J Cardiol. 2011 Mar 3;147(2):258-64
pubmed: 19923020
J Thorac Cardiovasc Surg. 2002 Mar;123(3):557-61
pubmed: 11882831
Clin Exp Immunol. 2014 Apr;176(1):120-8
pubmed: 24329680
Nat Rev Immunol. 2012 Jan 20;12(2):136-48
pubmed: 22266691
Obesity (Silver Spring). 2013 Mar;21(3):461-8
pubmed: 23592653
PLoS One. 2011 Jan 26;6(1):e16376
pubmed: 21298111
Adipocyte. 2021 Dec;10(1):435-445
pubmed: 34515616
JTCVS Open. 2021 Aug 12;8:405-411
pubmed: 36004147
Obesity (Silver Spring). 2016 Mar;24(3):615-25
pubmed: 26857091
Immunity. 2007 Feb;26(2):241-55
pubmed: 17307705
Cell Rep. 2014 Oct 23;9(2):605-17
pubmed: 25310975
Sci Rep. 2019 Sep 9;9(1):12887
pubmed: 31501486
Int J Artif Organs. 2012 Mar;35(3):169-76
pubmed: 22461111
Mol Immunol. 2011 Oct;49(1-2):234-8
pubmed: 21940050
J Diabetes Res. 2020 Oct 15;2020:2583257
pubmed: 33123595
Am J Hematol. 2005 Apr;78(4):314-5
pubmed: 15795906
Int J Obes (Lond). 2013 Nov;37(11):1510-3
pubmed: 23439322
Cell Immunol. 2000 Jan 10;199(1):15-24
pubmed: 10675271
FEBS Lett. 2007 Jul 24;581(18):3334-40
pubmed: 17601575
JACC Heart Fail. 2016 Oct;4(10):761-768
pubmed: 27614942
Med Sci (Basel). 2018 Oct 08;6(4):
pubmed: 30297662
ASAIO J. 2019 Sep/Oct;65(7):678-682
pubmed: 30398982
Diabetes. 2016 Nov;65(11):3440-3452
pubmed: 27561727
J Clin Invest. 1999 Oct;104(8):1051-9
pubmed: 10525043