Early short-term effects on catecholamine levels and pituitary function in patients with pheochromocytoma or paraganglioma treated with [
DOTATATE
PRRT
[177 Lu]
[68 Ga]
catecholamines
pheochromocytoma and paraganglioma
pituitary
targeted radiotherapy
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
08
2023
accepted:
28
09
2023
medline:
30
10
2023
pubmed:
27
10
2023
entrez:
27
10
2023
Statut:
epublish
Résumé
While there are reports of treatment-related endocrine disruptions and catecholamine surges in pheochromocytoma/paraganglioma (PPGL) patients treated with [ The study population included patients (≥18 years) enrolled in a phase 2 trial for treatment of somatostatin receptor (SSTR)-2+ inoperable/metastatic pheochromocytoma/paraganglioma with [ Among the 27 patients (age: 54 ± 12.7 years, 48.1% females) who underwent hormonal evaluation, hypoprolactinemia (14.1%), elevated FSH (13.1%), and elevated LH (12.5%) were the most frequent hormonal abnormalities across all 4 cycles combined. On longitudinal follow-up, significant reductions were noted in i. ACTH without corresponding changes in cortisol, ii. TSH, and FT4, and iii. prolactin at or before day-30 of [ [ https://clinicaltrials.gov/ct2/show/NCT03206060?term=NCT03206060&draw=2&rank=1, identifier NCT03206060.
Identifiants
pubmed: 37886645
doi: 10.3389/fendo.2023.1275813
pmc: PMC10598842
doi:
Substances chimiques
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
1HTE449DGZ
Prolactin
9002-62-4
Hydrocortisone
WI4X0X7BPJ
Adrenocorticotropic Hormone
9002-60-2
Follicle Stimulating Hormone
9002-68-0
Catecholamines
0
Thyrotropin
9002-71-5
Banques de données
ClinicalTrials.gov
['NCT03206060']
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1275813Subventions
Organisme : Intramural NIH HHS
ID : ZIA BC011789
Pays : United States
Informations de copyright
Copyright © 2023 Gubbi, Al-Jundi, Auh, Jha, Zou, Shamis, Meuter, Knue, Turkbey, Lindenberg, Mena, Carrasquillo, Teng, Pacak, Klubo-Gwiezdzinska, Del Rivero and Lin.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers at the time of submission. This had no impact on the peer review process and the final decision.
Références
J Clin Pathol. 2006 Mar;59(3):274-9
pubmed: 16505278
Pancreas. 2021 Apr 1;50(4):469-493
pubmed: 33939658
J Clin Oncol. 2008 May 1;26(13):2124-30
pubmed: 18445841
J Clin Oncol. 2018 Oct 1;36(28):2854-2862
pubmed: 30118397
Nucl Med Mol Imaging. 2015 Sep;49(3):223-30
pubmed: 26279696
J Clin Endocrinol Metab. 1996 Apr;81(4):1495-501
pubmed: 8636357
N Engl J Med. 2017 Jan 12;376(2):125-135
pubmed: 28076709
Scand J Gastroenterol Suppl. 1986;119:84-95
pubmed: 2876510
J Clin Endocrinol Metab. 2016 Feb;101(2):364-89
pubmed: 26760044
Clin Nucl Med. 2022 Feb 1;47(2):e184-e186
pubmed: 34507333
Clin Endocrinol (Oxf). 2005 Jun;62(6):742-7
pubmed: 15943838
Clin Nucl Med. 2013 Mar;38(3):188-94
pubmed: 23412597
Nucl Med Commun. 2010 Dec;31(12):1025-32
pubmed: 20926978
Neuroendocrinology. 2021;111(4):344-353
pubmed: 32259830
Eur J Nucl Med Mol Imaging. 2013 Dec;40(12):1843-52
pubmed: 23877632
Eur J Nucl Med. 2001 Jul;28(7):836-46
pubmed: 11504080
Eur J Nucl Med Mol Imaging. 2011 Jul;38(7):1224-36
pubmed: 21369945
J Natl Compr Canc Netw. 2018 Jun;16(6):693-702
pubmed: 29891520
EJNMMI Res. 2021 Aug 16;11(1):73
pubmed: 34398356
Clin Imaging. 2019 Nov - Dec;58:46-49
pubmed: 31238185
Eur J Nucl Med Mol Imaging. 2009 Nov;36(11):1758-66
pubmed: 19471926
Front Endocrinol (Lausanne). 2021 Jan 21;11:587065
pubmed: 33551992
J Clin Endocrinol Metab. 2018 May 1;103(5):1715-1744
pubmed: 29562364
Horm Metab Res. 1992 Jan;24(1):34-8
pubmed: 1612557
Pituitary. 2009;12(1):40-50
pubmed: 18270844
J Am Geriatr Soc. 1999 Dec;47(12):1422-4
pubmed: 10591235
Cancers (Basel). 2019 Aug 06;11(8):
pubmed: 31390824
Endokrynol Pol. 2015;66(3):231-6
pubmed: 26136132
Lancet. 1968 Nov 23;2(7578):1105-9
pubmed: 4177160
Hum Pathol. 2015 Mar;46(3):390-6
pubmed: 25554089
Thyroid. 2016 Jun;26(6):831-5
pubmed: 27094616
J Mol Endocrinol. 2008 Jun;40(6):263-71
pubmed: 18502819
Eur J Nucl Med. 1997 Jul;24(7):728-31
pubmed: 9211757