A Review of the Clinical Features and Management of Systemic Congenital Mastocytosis through the Presentation of An Unusual Prenatal-Onset Case.


Journal

Current oncology (Toronto, Ont.)
ISSN: 1718-7729
Titre abrégé: Curr Oncol
Pays: Switzerland
ID NLM: 9502503

Informations de publication

Date de publication:
03 10 2023
Historique:
received: 29 08 2023
revised: 23 09 2023
accepted: 01 10 2023
medline: 30 10 2023
pubmed: 27 10 2023
entrez: 27 10 2023
Statut: epublish

Résumé

Mastocytosis is a heterogeneous group of rare hematological disorders that can occur in infancy. We report a 16-year-old girl who presented with an aggressive form of systemic congenital mastocytosis, associated with a significant global developmental delay, deafness, and multiple anomalies. At 4 years of age, she developed a germinoma presenting as an invasive spinal mass. Extensive cytogenetic, metabolic, and molecular genetic studies that included whole-exome sequencing studies revealed a

Identifiants

pubmed: 37887549
pii: curroncol30100649
doi: 10.3390/curroncol30100649
pmc: PMC10605361
doi:

Substances chimiques

Proto-Oncogene Proteins c-kit EC 2.7.10.1

Types de publication

Review Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

8992-9003

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Auteurs

Valérie Larouche (V)

Department of Pediatric Hemato-oncology, Centre Hospitalier Universitaire de Quebec-Université Laval, Quebec, QC G1V4G2, Canada.

Marie-Frédérique Paré (MF)

Medecine Faculty, Laval University, Quebec, QC G1V4G2, Canada.

Pierre-Olivier Grenier (PO)

Department of Dermatology, Centre Hospitalier Universitaire de Quebec-Université Laval, Quebec, QC G1V4G2, Canada.

Anna Wieckowska (A)

Departement of Pediatric, Centre Hospitalier Universitaire de Quebec-Université Laval, Quebec, QC G1V4G2, Canada.

Eric Gagné (E)

Department of Pathology, Centre Hospitalier Universitaire de Quebec-Université Laval, Quebec, QC G1V4G2, Canada.

Rachel Laframboise (R)

Department of Medical Genetics, Centre Hospitalier Universitaire de Quebec-Université Laval, Quebec, QC G1V4G2, Canada.

Nada Jabado (N)

Department of Pediatric Hemato-Oncology, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC G1V4G2, Canada.

Isabelle De Bie (I)

Division of Medical Genetics, Department of Specialized Medicine, McGill University Health Centre, Montreal, QC G1V4G2, Canada.

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