CFD-DEM investigation of the effects of aperture size for a capsule-based dry powder inhaler.
Aerolizer
Capsule aperture
Dry powder inhaler (DPI)
computational fluid dynamics (CFD)
discrete element method (DEM)
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Nov 2023
25 Nov 2023
Historique:
received:
05
07
2023
revised:
02
10
2023
accepted:
24
10
2023
medline:
20
11
2023
pubmed:
28
10
2023
entrez:
27
10
2023
Statut:
ppublish
Résumé
Capsule based dry powder inhalers (DPIs) often require piercing of the capsule before inhalation, and the characteristics of the apertures (punctured holes) affect air flow and the release of powders from the capsule. This work develops a numerical model based on the two-way coupling of computational fluid dynamics and discrete element method (CFD-DEM) to investigate the effect of aperture size on powder dispersion in the Aerolizer® device loaded with only carrier particles (lactose). Powders (carrier particles) in the size range 60-140 μm (d
Identifiants
pubmed: 37890648
pii: S0378-5173(23)00977-8
doi: 10.1016/j.ijpharm.2023.123556
pii:
doi:
Substances chimiques
Aerosols
0
Powders
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123556Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.