Effect of Oleoylethanolamide-Based Dietary Supplement on Systemic Inflammation in the Development of Alimentary-Induced Obesity in Mice.
OEA
cytokines
inflammation
obesity
oleoylethanolamide
spleen
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
12 Oct 2023
12 Oct 2023
Historique:
received:
14
09
2023
revised:
06
10
2023
accepted:
10
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
The complex effect of oleoylethanolamide-based dietary supplement (OEA-DS) was studied in a model of diet-induced obesity in mice. Physiological, biochemical, and immunohistochemical methods were used to reveal differences in the changes in the weight of experimental animals, morphological changes in the spleen tissues, and changes in the cytokine expression profile in the spleen, blood plasma, and macrophage cell culture. First, it is shown that a hypercaloric diet high in carbohydrates and cholesterol led to the development of systemic inflammation, accompanied by organ morphological changes and increased production of proinflammatory cytokines. In parallel, the use of OEA-DS reduced the intensity of cellular inflammatory reactions, accompanied by a decrease in markers of cellular inflammation and proliferation, such as CD68, Iba-1, and Ki67 in the spleen tissue, and stabilized the level of proinflammatory cytokines (IL-1β, IL-6, TNFα) both in animals and in cell culture. In addition, in the macrophage cell culture (RAW264.7), it was shown that OEA-DS also suppressed the production of reactive oxygen species and nitrites in LPS-induced inflammation. The results of this study indicate the complex action of OEA-DS in obesity, which includes a reduction of systemic inflammation.
Identifiants
pubmed: 37892420
pii: nu15204345
doi: 10.3390/nu15204345
pmc: PMC10609781
pii:
doi:
Substances chimiques
oleoylethanolamide
1HI5J9N8E6
Oleic Acids
0
oleoyl ethanolamine
0
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Biochim Biophys Acta. 2015 Sep;1851(9):1218-26
pubmed: 26024927
Nature. 2003 Sep 4;425(6953):90-3
pubmed: 12955147
Cell. 2014 Dec 4;159(6):1327-40
pubmed: 25480297
BMJ. 2016 Feb 17;352:i581
pubmed: 26888382
Eur J Pharmacol. 2013 Jan 15;699(1-3):6-13
pubmed: 23201070
Br J Nutr. 2015 Apr;113 Suppl 2:S19-28
pubmed: 26148918
Neuropsychopharmacology. 2020 Oct;45(11):1931-1941
pubmed: 32353860
Front Endocrinol (Lausanne). 2020 Apr 03;11:178
pubmed: 32308645
Lipids. 2011 May;46(5):463-7
pubmed: 21461869
Lancet. 2007 Jan 6;369(9555):71-7
pubmed: 17208644
Am J Public Health. 1991 Jul;81(7):880-4
pubmed: 1647144
N Am J Med Sci. 2012 Apr;4(4):180-4
pubmed: 22536561
Pharmacol Biochem Behav. 2010 Jun;95(4):375-82
pubmed: 20347862
J Exp Med. 1991 Oct 1;174(4):827-36
pubmed: 1919437
Front Physiol. 2018 May 01;9:419
pubmed: 29765329
J Hepatol. 2016 Jun;64(6):1403-15
pubmed: 26867490
Nutrients. 2018 Aug 23;10(9):
pubmed: 30142886
Trends Endocrinol Metab. 2013 Jul;24(7):332-41
pubmed: 23567058
Diabetes Obes Metab. 2017 Jun;19(6):906-908
pubmed: 28105738
Mol Metab. 2023 Jan;67:101649
pubmed: 36462626
Physiol Behav. 2000 Jan;68(3):353-9
pubmed: 10716545
Prog Lipid Res. 2010 Oct;49(4):299-315
pubmed: 20152858
J Neurosci. 2011 Apr 13;31(15):5730-6
pubmed: 21490214
Sci Rep. 2016 Oct 10;6:34611
pubmed: 27721381
Front Endocrinol (Lausanne). 2023 Apr 05;14:1135157
pubmed: 37091842
Nutrients. 2019 Jun 30;11(7):
pubmed: 31262054
Nature. 1998 Jun 25;393(6687):790-3
pubmed: 9655393
Annu Rev Pharmacol Toxicol. 2007;47:565-92
pubmed: 17002599
J Biol Chem. 2003 Jun 13;278(24):21909-19
pubmed: 12676954
Int J Eat Disord. 2001 Jan;29(1):17-22
pubmed: 11135328
Curr Obes Rep. 2021 Jun;10(2):70-80
pubmed: 33512641
J Cell Sci. 2000 Sep;113 ( Pt 17):3073-84
pubmed: 10934045
Food Funct. 2016 Dec 7;7(12):4734-4744
pubmed: 27885367
Front Endocrinol (Lausanne). 2023 Feb 01;14:1085799
pubmed: 36843578
J Ultrasound Med. 2011 Sep;30(9):1281-93
pubmed: 21876100
FASEB J. 2011 Feb;25(2):765-74
pubmed: 20959516
Circ Res. 2007 Jul 6;101(1):27-39
pubmed: 17615379
Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1396-400
pubmed: 7877989
Maturitas. 2018 Dec;118:60-66
pubmed: 30415757
Chem Biodivers. 2007 Aug;4(8):1914-25
pubmed: 17712833
Nat Med. 2007 Jan;13(1):35-7
pubmed: 17159985
Gastroenterology. 2007 May;132(6):2239-52
pubmed: 17498515
Immunol Rev. 2016 Jan;269(1):44-59
pubmed: 26683144
J Biol Chem. 1999 Nov 5;274(45):32048-54
pubmed: 10542237
Endocr Rev. 2006 Feb;27(1):73-100
pubmed: 16306385
Cell. 2014 Dec 4;159(6):1312-26
pubmed: 25480296
J Biol Chem. 2001 Sep 21;276(38):35552-7
pubmed: 11463796
J Surg Res. 1991 May;50(5):529-34
pubmed: 2038192
Food Funct. 2021 Nov 15;12(22):11214-11228
pubmed: 34647565
Aging Cell. 2015 Aug;14(4):524-33
pubmed: 25847140
J Biol Chem. 2005 Mar 25;280(12):11082-92
pubmed: 15655246
Diabetes. 2003 Apr;52(4):942-7
pubmed: 12663465
Int J Obes (Lond). 2006 Sep;30(9):1347-55
pubmed: 16534530
Int J Clin Pharmacol Ther. 1998 Jun;36(6):345-9
pubmed: 9660044
Genomics. 1998 Jun 1;50(2):199-205
pubmed: 9653646
J Cell Physiol. 2000 Mar;182(3):311-22
pubmed: 10653597
Antioxid Redox Signal. 2013 Jun 10;18(17):2352-63
pubmed: 22900885
Diabetes Obes Metab. 2017 Mar;19(3):336-347
pubmed: 27860132
PLoS One. 2013 Nov 15;8(11):e80908
pubmed: 24260507
Eur J Gastroenterol Hepatol. 2009 May;21(5):504-11
pubmed: 19318968
Biochem Biophys Res Commun. 1996 Jul 25;224(3):855-62
pubmed: 8713135
Int J Mol Sci. 2021 Mar 17;22(6):
pubmed: 33802689
J Inflamm (Lond). 2009 Mar 16;6:6
pubmed: 19291292
PLoS Med. 2006 Jun;3(6):e287
pubmed: 16737350
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71
pubmed: 23671105
Nature. 2001 Jan 11;409(6817):198-201
pubmed: 11196644
Mini Rev Med Chem. 2007 Jan;7(1):3-10
pubmed: 17266632