Synthesis and Characterization of Antibacterial Chitosan Films with Ciprofloxacin in Acidic Conditions.
antibacterial activity
chitosan
ciprofloxacin
drug
structural investigation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Oct 2023
13 Oct 2023
Historique:
received:
29
08
2023
revised:
07
10
2023
accepted:
09
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
This work presents the results of research on obtaining chitosan (CS) films containing on their surface ciprofloxacin (CIP). A unique structure was obtained that not only gives new properties to the films, but also changes the way of coverage and structure of the surface. The spectroscopic test showed that in the process of application of CIP on the surface of CS film, CIP was converted from its crystalline form to an amorphic one, hence improving its bioavailability. This improved its scope of microbiological effect. The research was carried out on the reduction of CIP concentration during the process of CIP adhesion to the surface of chitosan films. The antibacterial activity of the CS films with and without the drug was evaluated in relation to
Identifiants
pubmed: 37894841
pii: ijms242015163
doi: 10.3390/ijms242015163
pmc: PMC10606985
pii:
doi:
Substances chimiques
Chitosan
9012-76-4
Ciprofloxacin
5E8K9I0O4U
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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