Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation.
TRPM channels
calcium homeostasis
calmodulin
calmodulin binding site
regulation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Oct 2023
13 Oct 2023
Historique:
received:
19
08
2023
revised:
05
10
2023
accepted:
11
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulation, and one of the key regulatory mechanisms involves their interaction with calmodulin (CaM), a cytosol ubiquitous calcium-binding protein. The association between TRPM channels and CaM relies on the presence of specific CaM-binding domains in the channel structure. Upon CaM binding, the channel undergoes direct and/or allosteric structural changes and triggers down- or up-stream signaling pathways. According to current knowledge, ion channel members TRPM2, TRPM3, TRPM4, and TRPM6 are directly modulated by CaM, resulting in their activation or inhibition. This review specifically focuses on the interplay between TRPM channels and CaM and summarizes the current known effects of CaM interactions and modulations on TRPM channels in cellular physiology.
Identifiants
pubmed: 37894842
pii: ijms242015162
doi: 10.3390/ijms242015162
pmc: PMC10607381
pii:
doi:
Substances chimiques
Calmodulin
0
TRPM Cation Channels
0
Calcium-Binding Proteins
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
ID : RVO: 61388963
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