Hematologic Neoplasms Associated with Down Syndrome: Cellular and Molecular Heterogeneity of the Diseases.

Down syndrome acute lymphoblastic leukemia acute myeloid leukemia multi-omics approach personalized medicine single-cell RNA sequencing trisomy 21

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
18 Oct 2023
Historique:
received: 22 09 2023
revised: 10 10 2023
accepted: 12 10 2023
medline: 30 10 2023
pubmed: 28 10 2023
entrez: 28 10 2023
Statut: epublish

Résumé

The molecular basis of Down syndrome (DS) predisposition to leukemia is not fully understood but involves various factors such as chromosomal abnormalities, oncogenic mutations, epigenetic alterations, and changes in selection dynamics. Myeloid leukemia associated with DS (ML-DS) is preceded by a preleukemic phase called transient abnormal myelopoiesis driven by

Identifiants

pubmed: 37895004
pii: ijms242015325
doi: 10.3390/ijms242015325
pmc: PMC10607483
pii:
doi:

Substances chimiques

Janus Kinases EC 2.7.10.2
STAT Transcription Factors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Ministero della Salute
ID : Ricerca corrente

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Auteurs

Edoardo Peroni (E)

Immunology and Molecular Oncology Unit, Veneto Institute of Oncology, IOV-IRCCS, 35128 Padova, Italy.

Michele Gottardi (M)

Onco Hematology, Department of Oncology, Veneto Institute of Oncology, IOV-IRCCS, 31033 Padua, Italy.

Lucia D'Antona (L)

Medical Genetics Unit, Mater Domini University Hospital, 88100 Catanzaro, Italy.

Maria Luigia Randi (ML)

First Medical Clinic, Department of Medicine-DIMED, University of Padova, 35128 Padova, Italy.

Antonio Rosato (A)

Immunology and Molecular Oncology Unit, Veneto Institute of Oncology, IOV-IRCCS, 35128 Padova, Italy.
Department of Surgery Oncology and Gastroenterology, University of Padova, 35122 Padova, Italy.

Giacomo Coltro (G)

Department of Clinical and Experimental Medicine, University of Florence, 50134 Florence, Italy.
Center of Research and Innovation for Myeloproliferative Neoplasms, CRIMM, AOU Careggi, 50134 Florence, Italy.

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Classifications MeSH