Involvement of Sirtuin 1 in the Growth Hormone/Insulin-like Growth Factor 1 Signal Transduction and Its Impact on Growth Processes in Children.
IGF-1
JAK2-STAT pathway
growth hormone
short stature children
sirtuin 1
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Oct 2023
20 Oct 2023
Historique:
received:
07
09
2023
revised:
01
10
2023
accepted:
19
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
The regulation of growth processes in children depends on the synthesis of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Insulin-like growth factor 1, which is mainly secreted in the liver in response to GH, is the main peripheral mediator of GH action. Newly discovered factors regulating GH secretion and its effects are being studied recently. One of them is sirtuin 1 (SIRT1). This NAD
Identifiants
pubmed: 37895086
pii: ijms242015406
doi: 10.3390/ijms242015406
pmc: PMC10607608
pii:
doi:
Substances chimiques
Human Growth Hormone
12629-01-5
Insulin-Like Growth Factor I
67763-96-6
Sirtuin 1
EC 3.5.1.-
SIRT1 protein, human
EC 3.5.1.-
IGF1 protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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