Uncovering neural pathways underlying bulimia nervosa: resting-state neural connectivity disruptions correlate with maladaptive eating behaviors.
Bulimia nervosa
Eating behavior
Functional connectivity
Principal component analysis
Surface-based regional homogeneity
Visual information
Journal
Eating and weight disorders : EWD
ISSN: 1590-1262
Titre abrégé: Eat Weight Disord
Pays: Germany
ID NLM: 9707113
Informations de publication
Date de publication:
30 Oct 2023
30 Oct 2023
Historique:
received:
19
03
2023
accepted:
18
10
2023
medline:
31
10
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
epublish
Résumé
Bulimia nervosa (BN) is characterized by recurrent binge-eating episodes and inappropriate compensatory behaviors. This study investigated alterations in resting-state surface-based neural activity in BN patients and explored correlations between brain activity and eating behavior. A total of 26 BN patients and 28 healthy controls were enrolled. Indirect measurement of cerebral cortical activity and functional connectivity (FC) analyses were performed in Surfstat. A principal component analysis (PCA) model was used to capture the commonalities within the behavioral questionnaires from the BN group. Compared with the healthy control group, the BN group showed decreased surface-based two-dimensional regional homogeneity in the right superior parietal lobule (SPL). Additionally, the BN group showed decreased FC between the right SPL and the bilateral lingual gyrus and increased FC between the right SPL and the left caudate nucleus and right putamen. In the FC-behavior association analysis, the second principal component (PC2) was negatively correlated with FC between the right SPL and the left caudate nucleus. The third principal component (PC3) was negatively correlated with FC between the right SPL and the left lingual gyrus and positively correlated with FC between the right SPL and the right lingual gyrus. We revealed that the right SPL undergoes reorganization with respect to specific brain regions at the whole-brain level in BN. In addition, our results suggest a correlation between brain reorganization and maladaptive eating behavior. These findings may provide useful information to better understand the neural mechanisms of BN. V, descriptive study.
Identifiants
pubmed: 37899387
doi: 10.1007/s40519-023-01617-5
pii: 10.1007/s40519-023-01617-5
pmc: PMC10613592
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
91Subventions
Organisme : National Natural Science Foundation of China
ID : 82001790
Informations de copyright
© 2023. The Author(s).
Références
Int J Eat Disord. 2013 Jul;46(5):462-9
pubmed: 23658093
Int J Eat Disord. 2006 Dec;39(8):685-93
pubmed: 16937383
Oper Neurosurg (Hagerstown). 2021 Aug 16;21(3):E199-E214
pubmed: 34246196
Eat Behav. 2001 Summer;2(2):105-12
pubmed: 15001040
Neuropsychologia. 2016 Apr;84:70-80
pubmed: 26471712
J Neurosci. 2009 Nov 25;29(47):14980-6
pubmed: 19940193
Behav Res Methods. 2018 Aug;50(4):1694-1715
pubmed: 29667082
Front Neuroanat. 2016 Mar 24;10:32
pubmed: 27047351
Biol Psychiatry. 2011 Aug 15;70(4):334-42
pubmed: 21791259
J Headache Pain. 2020 Feb 17;21(1):17
pubmed: 32066379
Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2465-70
pubmed: 17267613
Biol Psychiatry. 2005 Dec 15;58(12):990-7
pubmed: 16084858
PLoS One. 2014 Jul 24;9(7):e103492
pubmed: 25057823
Eur Neuropsychopharmacol. 2010 Aug;20(8):519-34
pubmed: 20471808
Neuroimage. 2004 May;22(1):394-400
pubmed: 15110032
J Affect Disord. 2012 Dec 20;143(1-3):56-63
pubmed: 22749158
Hum Brain Mapp. 2019 Jun 1;40(8):2488-2498
pubmed: 30720907
Front Neural Circuits. 2021 Oct 14;15:727960
pubmed: 34720887
Int J Neuropsychopharmacol. 2020 Jun 24;23(6):356-365
pubmed: 32215560
Psychol Health Med. 2017 Mar;22(3):282-288
pubmed: 27080537
Neuron. 2019 May 8;102(3):529-552
pubmed: 31071288
Int J Eat Disord. 1997 Mar;21(2):187-94
pubmed: 9062843
Curr Probl Pediatr Adolesc Health Care. 2017 Apr;47(4):85-94
pubmed: 28532966
J Affect Disord. 2019 May 15;251:78-85
pubmed: 30909161
J Psychiatry Neurosci. 2016 Aug;41(5):E69-78
pubmed: 27575858
Nat Methods. 2019 Jan;16(1):111-116
pubmed: 30532080
Psychiatry Res. 2015 Dec 15;230(2):294-9
pubmed: 26416590
Science. 1995 Nov 3;270(5237):802-5
pubmed: 7481770
IEEE Trans Med Imaging. 2003 Feb;22(2):217-27
pubmed: 12715998
Nat Protoc. 2018 Dec;13(12):2801-2826
pubmed: 30446748
J Clin Psychol. 1990 Jan;46(1):35-43
pubmed: 2303562
PLoS One. 2016 Sep 08;11(9):e0161329
pubmed: 27607439
Exp Brain Res. 2003 Nov;153(2):146-57
pubmed: 14610633
Cereb Cortex. 2007 Nov;17(11):2703-12
pubmed: 17264251
Neurosci Lett. 2010 May 26;476(1):46-51
pubmed: 20381584
Psychosomatics. 1971 Nov-Dec;12(6):371-9
pubmed: 5172928
Neuroradiol J. 2017 Aug;30(4):305-317
pubmed: 28353416
Neuroimage. 2006 Dec;33(4):1093-103
pubmed: 17011792
Am J Psychiatry. 2004 Jul;161(7):1238-46
pubmed: 15229057
Dis Markers. 2020 Dec 28;2020:6683161
pubmed: 33456630
Front Behav Neurosci. 2014 Aug 04;8:270
pubmed: 25136302
Neuroimage. 2012 Nov 15;63(3):1443-53
pubmed: 22732555
Brain Cogn. 2019 Apr;131:66-73
pubmed: 29030069
Eur Eat Disord Rev. 2017 Nov;25(6):613-617
pubmed: 28994215
Neuropsychologia. 2009 Dec;47(14):3033-44
pubmed: 19563817
Eur Eat Disord Rev. 2012 Nov;20(6):490-5
pubmed: 22585557
Hum Brain Mapp. 2021 Apr 15;42(6):1879-1887
pubmed: 33400306
World Neurosurg. 2021 Jul;151:e426-e437
pubmed: 33894399