[Research advances on application of pancreatic stone protein in the early diagnosis of sepsis].

Sepsis is a severe life-threatening syndrome characterized by an abnormal host response to infection that can rapidly evolve into septic shock and multiple organ failure. Treatment of sepsis depends on early identification and diagnosis as well as adequate and timely anti-infection and multi-organ functional support. In recent years, pancreatic stone protein has been widely studied as a new biomarker for sepsis. Existing evidence shows that compared with the commonly used inflammatory markers in clinical practice, pancreatic stone protein has higher sensitivity and specificity in the diagnosis of sepsis. It enables the early diagnosis of sepsis and assessment of the severity of septic patients to a certain extent. This article reviews the characteristics, biological functions, diagnostic features, and clinical application of pancreatic stone protein. 脓毒症是一种严重危及生命的综合征，其主要特征是宿主对感染的异常反应，可迅速演变为脓毒症休克和多器官功能衰竭。脓毒症的治疗依赖于早期识别和诊断以及充分而及时的抗感染和多器官功能支持。近年来，胰石蛋白作为一种新的脓毒症生物标志物被广泛研究。现有证据表明，与目前临床上常用的炎症标志物相比，胰石蛋白对脓毒症的诊断具有更高的敏感度和特异度，并且能对脓毒症进行早期识别，可在一定程度上评估脓毒症患者病情的严重程度。该文就胰石蛋白的特征、生物学功能、诊断特点以及临床应用的研究进展作一综述。.