The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis.
Wnt signaling
cancer biology
colorectal cancer
developmental biology
lysosomes
macropinocytosis
xenopus
β-catenin
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
30 10 2023
30 10 2023
Historique:
medline:
31
10
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
epublish
Résumé
Activation of the Wnt pathway lies at the core of many human cancers. Wnt and macropinocytosis are often active in the same processes, and understanding how Wnt signaling and membrane trafficking cooperate should improve our understanding of embryonic development and cancer. Here, we show that a macropinocytosis activator, the tumor promoter phorbol 12-myristate 13-acetate (PMA), enhances Wnt signaling. Experiments using the
Identifiants
pubmed: 37902809
doi: 10.7554/eLife.89141
pii: 89141
pmc: PMC10615368
doi:
pii:
Substances chimiques
Carcinogens
0
Glycogen Synthase Kinase 3
EC 2.7.11.26
Phorbol Esters
0
Esters
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P30 CA016042
Pays : United States
Organisme : NIH HHS
ID : P20CA016042
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023, Tejeda-Munoz, Azbazdar et al.
Déclaration de conflit d'intérêts
NT, YA, JM, GB, AD, RA, NO, ED No competing interests declared
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