T Cell Antigen Recognition and Discrimination by Electrochemiluminescence Imaging.
Antigen Recognition and Discrimination
Electrochemiluminescence
Immune Synapse
Label-Free Imaging
T Cell Receptor
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
11 Dec 2023
11 Dec 2023
Historique:
received:
11
10
2023
medline:
7
12
2023
pubmed:
31
10
2023
entrez:
30
10
2023
Statut:
ppublish
Résumé
Adoptive T lymphocyte (T cell) transfer and tumour-specific peptide vaccines are innovative cancer therapies. An accurate assessment of the specific reactivity of T cell receptors (TCRs) to tumour antigens is required because of the high heterogeneity of tumour cells and the immunosuppressive tumour microenvironment. In this study, we report a label-free electrochemiluminescence (ECL) imaging approach for recognising and discriminating between TCRs and tumour-specific antigens by imaging the immune synapses of T cells. Various T cell stimuli, including agonistic antibodies, auxiliary molecules, and tumour-specific antigens, were modified on the electrode's surface to allow for their interaction with T cells bearing different TCRs. The formation of immune synapses activated by specific stimuli produced a negative (shadow) ECL image, from which T cell antigen recognition and discrimination were evaluated by analysing the spreading area and the recognition intensity of T cells. This approach provides an easy way to assess TCR-antigen specificity and screen both of them for immunotherapies.
Identifiants
pubmed: 37903724
doi: 10.1002/anie.202314588
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Antigens, Neoplasm
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202314588Subventions
Organisme : National Natural Science Foundation of China
ID : 22125405
Organisme : National Natural Science Foundation of China
ID : 22074131
Informations de copyright
© 2023 Wiley-VCH GmbH.
Références
H. Sung, J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray, Ca-Cancer J. Clin. 2021, 71, 209.
D. S. Keller, M. Berho, R. O. Perez, S. D. Wexner, M. Chand, Nat. Rev. Gastroenterol. Hepatol. 2020, 17, 414;
M.-Y. Li, L.-Z. Liu, M. Dong, Mol. Cancer 2021, 20, 22.
A. D. Waldman, J. M. Fritz, M. J. Lenardo, Nat. Rev. Immunol. 2020, 20, 651.
N. P. Restifo, M. E. Dudley, S. A. Rosenberg, Nat. Rev. Immunol. 2012, 12, 269.
J. B. Huppa, M. Axmann, M. A. Mörtelmaier, B. F. Lillemeier, E. W. Newell, M. Brameshuber, L. O. Klein, G. J. Schütz, M. M. Davis, Nature 2010, 463, 963.
Y. Hu, V. P.-Y. Ma, R. Ma, W. Chen, Y. Duan, R. Glazier, B. G. Petrich, R. Li, K. Salaita, Angew. Chem. Int. Ed. 2021, 60, 18044;
P. Friedl, A. T. den Boer, M. Gunzer, Nat. Rev. Immunol. 2005, 5, 532;
S. Čemerski, A. Shaw, Curr. Opin. Immunol. 2006, 18, 298.
E. Kobayashi, A. Jin, H. Hamana, K. Shitaoka, K. Tajiri, S. Kusano, S. Yokoyama, T. Ozawa, T. Obata, A. Muraguchi, H. Kishi, Nat. Biomed. Eng. 2022, 6, 806;
H. Liu, H. Luo, Q. Xue, S. Qin, S. Qiu, S. Liu, J. Lin, J. P. Li, P. R. Chen, J. Am. Chem. Soc. 2022, 144, 5517;
M. Nami, P. Han, D. Hanlon, K. Tatsuno, B. Wei, O. Sobolev, M. Pitruzzello, A. Vassall, S. Yosinski, R. Edelson, M. Reed, Adv. Mater. 2022, 34, 2109661;
K. Zhang, Y. Ma, D. Wang, J. Liu, J. An, Y. Li, C. Ma, Y. Pei, Z. Zhang, J. Liu, J. Shi, Nano Lett. 2022, 22, 1937.
R. A. Subbramanian, C. Moriya, K. L. Martin, F. W. Peyerl, A. Hasegawa, A. Naoi, H. Chhay, P. Autissier, D. A. Gorgone, M. A. Lifton, K. Kuus-Reichel, J. E. Schmitz, N. L. Letvin, M. J. Kuroda, Nat. Biotechnol. 2004, 22, 1429.
J. F. Ashby, J. Schmidt, N. Kc, A. Kurum, C. Koch, A. Harari, L. Tang, S. H. Au, Adv. Healthcare Mater. 2022, 11, 2200169.
L. V. Sibener, R. A. Fernandes, E. M. Kolawole, C. B. Carbone, F. Liu, D. McAffee, M. E. Birnbaum, X. Yang, L. F. Su, W. Yu, S. Dong, M. H. Gee, K. M. Jude, M. M. Davis, J. T. Groves, W. A. Goddard, J. R. Heath, B. D. Evavold, R. D. Vale, K. C. Garcia, Cell 2018, 174, 672.
S. Viganò, D. T. Utzschneider, M. Perreau, G. Pantaleo, D. Zehn, A. Harari, Clin. Dev. Immunol. 2012, 2012, 153863;
S. Čemerski, J. Das, E. Giurisato, M. A. Markiewicz, P. M. Allen, A. K. Chakraborty, A. S. Shaw, Immunity 2008, 29, 414.
A. Siokis, P. A. Robert, P. Demetriou, M. L. Dustin, M. Meyer-Hermann, Cell Rep. 2018, 24, 1151.
W. E. Paul, R. A. Seder, Cell 1994, 76, 241.
L. Balagopalan, E. Sherman, V. A. Barr, L. E. Samelson, Nat. Rev. Immunol. 2011, 11, 21.
E. H. Doeven, E. M. Zammit, G. J. Barbante, C. F. Hogan, N. W. Barnett, P. S. Francis, Angew. Chem. Int. Ed. 2012, 51, 4354.
H. Ding, W. Guo, P. Zhou, B. Su, Chem. Commun. 2020, 56, 8249.
T.-B. Gao, J.-J. Zhang, J. Wen, X.-X. Yang, H.-B. Ma, D.-K. Cao, D. Jiang, Anal. Chem. 2020, 92, 1268.
F. Deiss, C. N. LaFratta, M. Symer, T. M. Blicharz, N. Sojic, D. R. Walt, J. Am. Chem. Soc. 2009, 131, 6088;
Y. Wang, J. Ding, P. Zhou, J. Liu, Z. Qiao, K. Yu, J. Jiang, B. Su, Angew. Chem. Int. Ed. 2023, 62, e202216525.
J. Dong, Y. Xu, Z. Zhang, J. Feng, Angew. Chem. Int. Ed. 2022, 61, e202200187.
H. Ding, P. Zhou, W. Fu, L. Ding, W. Guo, B. Su, Angew. Chem. Int. Ed. 2021, 60, 11769;
B. Li, X. Huang, Y. Lu, Z. Fan, B. Li, D. Jiang, N. Sojic, B. Liu, Adv. Sci. 2022, 9, 2204715;
G. Valenti, S. Scarabino, B. Goudeau, A. Lesch, M. Jović, E. Villani, M. Sentic, S. Rapino, S. Arbault, F. Paolucci, N. Sojic, J. Am. Chem. Soc. 2017, 139, 16830;
H. Ding, W. Guo, L. Ding, B. Su, Chin. J. Chem. 2021, 39, 2911.
Y. Ma, C. Colin, J. Descamps, S. Arbault, N. Sojic, Angew. Chem. Int. Ed. 2021, 60, 18742;
J. Descamps, C. Colin, G. Tessier, S. Arbault, N. Sojic, Angew. Chem. Int. Ed. 2023, 62, e202218574.
Y. Liu, H. Zhang, B. Li, J. Liu, D. Jiang, B. Liu, N. Sojic, J. Am. Chem. Soc. 2021, 143, 17910;
N. Wang, H. Gao, Y. Li, G. Li, W. Chen, Z. Jin, J. Lei, Q. Wei, H. Ju, Angew. Chem. Int. Ed. 2021, 60, 197.
X. Hu, S. Yu, C. Wang, X. Zhang, J. Pan, H. Ju, Anal. Chem. 2023, 95, 4496;
S. Voci, B. Goudeau, G. Valenti, A. Lesch, M. Jović, S. Rapino, F. Paolucci, S. Arbault, N. Sojic, J. Am. Chem. Soc. 2018, 140, 14753.
L. Xu, Z. Zhou, C. Zhang, Y. He, B. Su, Chem. Commun. 2014, 50, 9097;
L. Xu, Y. Li, S. Wu, X. Liu, B. Su, Angew. Chem. Int. Ed. 2012, 51, 8068.
H. Ding, W. Guo, B. Su, Angew. Chem. Int. Ed. 2020, 59, 449;
L. Ding, H. Ding, P. Zhou, L. Xi, B. Su, Anal. Chem. 2022, 94, 10885.
J. Zhang, S. Arbault, N. Sojic, D. Jiang, Annu. Rev. Anal. Chem. 2019, 12, 275.
F. Yan, X. Lin, B. Su, Analyst 2016, 141, 3482.
N. Kebede, P. S. Francis, G. J. Barbante, C. F. Hogan, Analyst 2015, 140, 7142.
W. Miao, J.-P. Choi, A. J. Bard, J. Am. Chem. Soc. 2002, 124, 14478;
M. Sentic, M. Milutinovic, F. Kanoufi, D. Manojlovic, S. Arbault, N. Sojic, Chem. Sci. 2014, 5, 2568;
A. Zanut, A. Fiorani, S. Canola, T. Saito, N. Ziebart, S. Rapino, S. Rebeccani, A. Barbon, T. Irie, H.-P. Josel, F. Negri, M. Marcaccio, M. Windfuhr, K. Imai, G. Valenti, F. Paolucci, Nat. Commun. 2020, 11, 2668;
W.-X. Fu, P. Zhou, W.-L. Guo, B. Su, Adv. Sens. Energy Mater. 2022, 1, 100028;
W. Guo, P. Zhou, L. Sun, H. Ding, B. Su, Angew. Chem. Int. Ed. 2021, 60, 2089.
C. Ma, M.-X. Wang, H.-F. Wei, S. Wu, J.-R. Zhang, J.-J. Zhu, Z. Chen, Chem. Commun. 2021, 57, 2168.
M. A. Al-Aghbar, A. K. Jainarayanan, M. L. Dustin, S. R. Roffler, Commun. Biol. 2022, 5, 40;
S. Minguet, M. Swamy, B. Alarcón, I. F. Luescher, W. W. A. Schamel, Immunity 2007, 26, 43.
L. Velas, M. Brameshuber, J. B. Huppa, E. Kurz, M. L. Dustin, P. Zelger, A. Jesacher, G. J. Schütz, Nano Lett. 2021, 21, 9247.
C. Ma, S. Wu, Y. Zhou, H.-F. Wei, J. Zhang, Z. Chen, J.-J. Zhu, Y. Lin, W. Zhu, Angew. Chem. Int. Ed. 2021, 60, 4907;
Y. Chen, X. Gou, C. Ma, D. Jiang, J.-J. Zhu, Anal. Chem. 2021, 93, 7682.
J. Oh, X. Xia, W. K. R. Wong, S. H. D. Wong, W. Yuan, H. Wang, C. H. N. Lai, Y. Tian, Y.-P. Ho, H. Zhang, Y. Zhang, G. Li, Y. Lin, L. Bian, Small 2022, 18, 2107373;
K. T. Bashour, A. Gondarenko, H. Chen, K. Shen, X. Liu, M. Huse, J. C. Hone, L. C. Kam, Proc. Natl. Acad. Sci. USA 2014, 111, 2241.
J. Deeg, M. Axmann, J. Matic, A. Liapis, D. Depoil, J. Afrose, S. Curado, M. L. Dustin, J. P. Spatz, Nano Lett. 2013, 13, 5619;
D. Delcassian, D. Depoil, D. Rudnicka, M. Liu, D. M. Davis, M. L. Dustin, I. E. Dunlop, Nano Lett. 2013, 13, 5608;
H. Cai, J. Muller, D. Depoil, V. Mayya, M. P. Sheetz, M. L. Dustin, S. J. Wind, Nat. Nanotechnol. 2018, 13, 610.
R. J. Brownlie, R. Zamoyska, Nat. Rev. Immunol. 2013, 13, 257.
V. P.-Y. Ma, Y. Hu, A. V. Kellner, J. M. Brockman, A. Velusamy, A. T. Blanchard, B. D. Evavold, R. Alon, K. Salaita, Sci. Adv. 2022, 8, eabg4485.
P. Nordenfelt, H. L. Elliott, T. A. Springer, Nat. Commun. 2016, 7, 13119.
A. Wahl, C. Dinet, P. Dillard, A. Nassereddine, P.-H. Puech, L. Limozin, K. Sengupta, Proc. Natl. Acad. Sci. USA 2019, 116, 5908;
J. Huang, P.-F. Lo, T. Żal, N. R. J. Gascoigne, B. A. Smith, S. D. Levin, H. M. Grey, Proc. Natl. Acad. Sci. USA 2002, 99, 9369.
E. Palmer, D. Naeher, Nat. Rev. Immunol. 2009, 9, 207.
R. N. Germain, I. Stefanová, Annu. Rev. Immunol. 1999, 17, 467.
M. Aleksic, O. Dushek, H. Zhang, E. Shenderov, J.-L. Chen, V. Cerundolo, D. Coombs, P. A. van der Merwe, Immunity 2010, 32, 163;
J.-L. Chen, P. R. Dunbar, U. Gileadi, E. Jäger, S. Gnjatic, Y. Nagata, E. Stockert, D. L. Panicali, Y.-T. Chen, A. Knuth, L. J. Old, V. Cerundolo, J. Immunol. 2000, 165, 948.
L. Wang, X. Lan, Cell Discov. 2022, 8, 30.
A. Poole, V. Karuppiah, A. Hartt, J. N. Haidar, S. Moureau, T. Dobrzycki, C. Hayes, C. Rowley, J. Dias, S. Harper, K. Barnbrook, M. Hock, C. Coles, W. Yang, M. Aleksic, A. B. Lin, R. Robinson, J. D. Dukes, N. Liddy, M. Van der Kamp, G. D. Plowman, A. Vuidepot, D. K. Cole, A. D. Whale, C. Chillakuri, Nat. Commun. 2022, 13, 5333.
H. Colin-York, S. Kumari, L. Barbieri, L. Cords, M. Fritzsche, J. Cell Sci. 2020, 133, jcs232322.
L. A. Colf, A. J. Bankovich, N. A. Hanick, N. A. Bowerman, L. L. Jones, D. M. Kranz, K. C. Garcia, Cell 2007, 129, 135.
Y. Lu, X. Huang, S. Wang, B. Li, B. Liu, ACS Nano 2023, 17, 3809.
M.-M. Chen, C.-H. Xu, W. Zhao, H.-Y. Chen, J.-J. Xu, J. Am. Chem. Soc. 2021, 143, 18511;
J. Dong, Y. Lu, Y. Xu, F. Chen, J. Yang, Y. Chen, J. Feng, Nature 2021, 596, 244;
Y. Zhou, J. Dong, P. Zhao, J. Zhang, M. Zheng, J. Feng, J. Am. Chem. Soc. 2023, 145, 8947.
J. Xu, P. Huang, Y. Qin, D. Jiang, H.-Y. Chen, Anal. Chem. 2016, 88, 4609.