PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy.
Journal
Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
16
01
2023
accepted:
22
09
2023
medline:
27
11
2023
pubmed:
31
10
2023
entrez:
31
10
2023
Statut:
ppublish
Résumé
Senescent cells remain metabolically active, but their metabolic landscape and resulting implications remain underexplored. Here, we report upregulation of pyruvate dehydrogenase kinase 4 (PDK4) upon senescence, particularly in some stromal cell lines. Senescent cells display a PDK4-dependent increase in aerobic glycolysis and enhanced lactate production but maintain mitochondrial respiration and redox activity, thus adopting a special form of metabolic reprogramming. Medium from PDK4
Identifiants
pubmed: 37903887
doi: 10.1038/s42255-023-00912-w
pii: 10.1038/s42255-023-00912-w
pmc: PMC10663165
doi:
Substances chimiques
pyruvate dehydrogenase kinase 4
EC 2.7.1.-
Lactic Acid
33X04XA5AT
Protein Kinases
EC 2.7.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1887-1910Informations de copyright
© 2023. The Author(s).
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