Progesterone induces meiosis through two obligate co-receptors with PLA2 activity.

ABHD2 Phospholipase A2 Xenopus laevis lipidomics meiosis membrane progesterone receptor β (mPRβ) metabolomics nongenomic oocyte maturation progesterone signaling

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
18 Oct 2023
Historique:
pubmed: 31 10 2023
medline: 31 10 2023
entrez: 31 10 2023
Statut: epublish

Résumé

The steroid hormone progesterone (P4) regulates multiple aspects of reproductive and metabolic physiology. Classical P4 signaling operates through nuclear receptors that regulate transcription. In addition, P4 signals through membrane P4 receptors (mPRs) in a rapid nongenomic modality. Despite the established physiological importance of P4 nongenomic signaling, its detailed signal transduction remains elusive. Here, using

Identifiants

pubmed: 37905030
doi: 10.1101/2023.09.09.556646
pmc: PMC10614741
pii:
doi:

Types de publication

Preprint

Langues

eng

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Auteurs

Nancy Nader (N)

Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Lubna Zarif (L)

Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.

Anna Halama (A)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.

Sharan Yadav (S)

Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.

Maya Dib (M)

Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.

Nabeel Attarwala (N)

Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
Biological Sciences division, University of Chicago, Chicago, IL, USA.

Qiuying Chen (Q)

Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.

Karsten Suhre (K)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.

Steven S Gross (SS)

Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.

Khaled Machaca (K)

Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Classifications MeSH