Khaled Machaca

Affiliations

Department of Physiology and Biophysics, Ca(2+) Signaling Group, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, PO Box 24144, Doha, Qatar. Electronic address: khm2002@qatar-med.cornell.edu.

Publications (29)

Ca

Cell calcium

Avec: Khaled Machaca

Novel ORAI1 Mutation Disrupts Channel Trafficking Resulting in Combined Immunodeficiency.

Journal of clinical immunology

Avec: Fang Yu , Nourhen Agrebi , Rafah Mackeh , Khaled Abouhazima , Khadija KhudaBakhsh , Mehdi Adeli , Bernice Lo , Amel Hassan , Khaled Machaca

IP

Current opinion in cell biology

Avec: Colin W Taylor , Khaled Machaca

Phosphorylation of STIM1 at ERK/CDK sites is dispensable for cell migration and ER partitioning in mitosis.

Cell calcium

Avec: Ayat S Hammad , Fang Yu , Welathanthrige S Botheju , Asha Elmi , Ethel Alcantara-Adap , Khaled Machaca

A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP-modulated NFAT signaling.

EMBO reports

Avec: Mona L Knapp , Dalia Alansary , Vanessa Poth , Kathrin Förderer , Frederik Sommer , David Zimmer , Yvonne Schwarz , Nicolas Künzel , Achim Kless , Khaled Machaca , Volkhard Helms , Timo Mühlhaus , Michael Schroda , Annette Lis , Barbara A Niemeyer

The QChip1 knowledgebase and microarray for precision medicine in Qatar.

NPJ genomic medicine

Avec: Juan L Rodriguez-Flores , Radja Messai-Badji , Amal Robay , Ramzi Temanni , Najeeb Syed , Monika Markovic , Eiman Al-Khayat , Fatima Qafoud , Zafar Nawaz , Ramin Badii , Yasser Al-Sarraj , Hamdi Mbarek , Wadha Al-Muftah , Muhammad Alvi , Mahboubeh R Rostami , Juan Carlos Martinez Cruzado , Jason G Mezey , Alya Al Shakaki , Joel A Malek , Matthew B Greenblatt , Khalid A Fakhro , Khaled Machaca , Ajayeb Al-Nabet , Nahla Afifi , Andrew Brooks , Said I Ismail , Asmaa Althani , Ronald G Crystal

Chronic reduction of store operated Ca

The Journal of physiology

Avec: Fang Yu , Raphael Courjaret , Asha Elmi , Ethel Alcantara Adap , Nelson N Orie , Fawzi Zghyer , Satanay Hubrack , Sajad Hayat , Nidal Asaad , Stefan Worgall , Manikkam Suthanthiran , Vidya Mohamed Ali , Khaled Machaca

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity.

The Journal of biological chemistry

Avec: Scott M Emrich , Ryan E Yoast , Ping Xin , Xuexin Zhang , Trayambak Pathak , Robert Nwokonko , Maxime F Gueguinou , Krishna P Subedi , Yandong Zhou , Indu S Ambudkar , Nadine Hempel , Khaled Machaca , Donald L Gill , Mohamed Trebak

L-type Ca

Proceedings of the National Academy of Sciences of the United States of America

Avec: Martin T Johnson , Aparna Gudlur , Xuexin Zhang , Ping Xin , Scott M Emrich , Ryan E Yoast , Raphael Courjaret , Robert M Nwokonko , Wei Li , Nadine Hempel , Khaled Machaca , Donald L Gill , Patrick G Hogan , Mohamed Trebak

The STIM1 Phosphorylation Saga.

Cell calcium

Avec: Fang Yu , Khaled Machaca

Mitochondria-ER contact sites expand during mitosis.

iScience

Avec: Fang Yu , Raphael Courjaret , Lama Assaf , Asha Elmi , Ayat Hammad , Melanie Fisher , Mark Terasaki , Khaled Machaca

Lipid Signaling During Gamete Maturation.

Frontiers in cell and developmental biology

Avec: Sherif Mostafa , Nancy Nader , Khaled Machaca

Selective modulation of gene expression in activated normal human peripheral blood mononuclear cells by store-operated calcium entry blocker BTP2.

Research square

Avec: Divya Shankaranarayanan , Madhav Mantri , Mila Lagman , Carol Li , Vijay K Sharma , Thangamani Muthukumar , Jenny Z Xiang , Iwijn De Vlaminck , Khaled Machaca , Manikkam Suthanthiran

Methods to Quantify the Dynamic Recycling of Plasma Membrane Channels.

Bio-protocol

Avec: Rawad Hodeify , Khaled Machaca

miRNA-dependent regulation of STIM1 expression in breast cancer.

Scientific reports

Avec: Rashmi P Kulkarni , Asha Elmi , Ethel Alcantara-Adap , Satanay Hubrack , Nancy Nader , Fang Yu , Maya Dib , Vimal Ramachandran , Hani Najafi Shoushtari , Khaled Machaca

Multifunctional rhodamine B appended ROMP derived fluorescent probe detects Al

Scientific reports

Avec: Upendar Reddy Gandra , Raphael Courjaret , Khaled Machaca , Mohammed Al-Hashimi , Hassan S Bazzi

Native SOCE complexes: Small but mighty?

Cell calcium

Avec: Raphael Courjaret , Khaled Machaca

STAT1- and NFAT-independent amplification of purinoceptor function integrates cellular senescence with interleukin-6 production in preadipocytes.

British journal of pharmacology

Avec: Yasser Majeed , Aisha Y Madani , Ahmed I Altamimi , Raphael Courjaret , Muneera Vakayil , Samuel J Fountain , Khaled Machaca , Nayef A Mazloum

SOCE as a regulator of neuronal activity.

The Journal of physiology

Avec: Raphael Courjaret , Murali Prakriya , Khaled Machaca

Blockade of store-operated calcium entry by BTP2 preserves anti-inflammatory gene expression in human peripheral blood mononuclear cells.

Human immunology

Avec: Divya Shankaranarayanan , Madhav Mantri , Mila Lagman , Carol Li , Vijay K Sharma , Thangamani Muthukumar , Jenny Z Xiang , Iwijn De Vlaminck , Khaled Machaca , Manikkam Suthanthiran

Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca

Proceedings of the National Academy of Sciences of the United States of America

Avec: Fang Yu , Satanay Z Hubrack , Sumita Chakraborty , Lu Sun , Ethel Alcantara-Adap , Rashmi Kulkarni , Anja M Billing , Johannes Graumann , Colin W Taylor , Khaled Machaca

Synthesis of TPEN variants to improve cancer cells selective killing capacity.

Bioorganic chemistry

Avec: Stephanie Schaefer-Ramadan , Maciej Barlog , Jim Roach , Mohammed Al-Hashimi , Hassan S Bazzi , Khaled Machaca

Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2.

PLoS biology

Avec: Nancy Nader , Maya Dib , Rawad Hodeify , Raphael Courjaret , Asha Elmi , Ayat S Hammad , Raja Dey , Xin-Yun Huang , Khaled Machaca

Correction: Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2.

PLoS biology

Avec: Nancy Nader , Maya Dib , Rawad Hodeify , Raphael Courjaret , Asha Elmi , Ayat S Hammad , Raja Dey , Xin-Yun Huang , Khaled Machaca

The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis.

Scientific reports

Avec: Rawad Hodeify , Maya Dib , Ethel Alcantara-Adap , Raphael Courjaret , Nancy Nader , Cleo Z Reyes , Ayat S Hammad , Satanay Hubrack , Fang Yu , Khaled Machaca

Store Operated Calcium Entry in Cell Migration and Cancer Metastasis.

Cells

Avec: Ayat S Hammad , Khaled Machaca

Progesterone induces meiosis through two obligate co-receptors with PLA2 activity.

bioRxiv : the preprint server for biology

Avec: Nancy Nader , Lubna Zarif , Anna Halama , Sharan Yadav , Maya Dib , Nabeel Attarwala , Qiuying Chen , Karsten Suhre , Steven S Gross , Khaled Machaca

STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration.

Cell calcium

Avec: Ayat S Hammad , Fang Yu , Jawaher Al-Hamaq , F David Horgen , Khaled Machaca

Loss of the TRPM4 channel in humans causes immune dysregulation with defective monocyte migration.

The Journal of allergy and clinical immunology

Avec: Fang Yu , Satanay Hubrack , Christophe M Raynaud , Asha Elmi , Rafah Mackeh , Nourhen Agrebi , Gaurav Thareja , Abdelaziz Belkadi , Hesham Al Saloos , Ayeda Abdulsalam Ahmed , Saleema C Purayil , Yasmin A Mohamoud , Karsten Suhre , Charbel Abi Khalil , Frank Schmidt , Bernice Lo , Amel Hassan , Khaled Machaca

Réseau de co-auteurs

Fang Yu 10 collaborations

Raphael Courjaret 10 collaborations

Asha Elmi 7 collaborations

Ayat S Hammad 6 collaborations

Nancy Nader 6 collaborations

Maya Dib 5 collaborations

Ethel Alcantara-Adap 4 collaborations

Satanay Hubrack 4 collaborations

Rawad Hodeify 4 collaborations

Manikkam Suthanthiran 3 collaborations

Nourhen Agrebi 2 collaborations

Rafah Mackeh 2 collaborations

Bernice Lo 2 collaborations

Amel Hassan 2 collaborations

Colin W Taylor 2 collaborations

Scott M Emrich 2 collaborations

Ryan E Yoast 2 collaborations

Ping Xin 2 collaborations

Xuexin Zhang 2 collaborations

Nadine Hempel 2 collaborations

Donald L Gill 2 collaborations

Mohamed Trebak 2 collaborations

Divya Shankaranarayanan 2 collaborations

Madhav Mantri 2 collaborations

Mila Lagman 2 collaborations

Carol Li 2 collaborations

Vijay K Sharma 2 collaborations

Thangamani Muthukumar 2 collaborations

Jenny Z Xiang 2 collaborations

Iwijn De Vlaminck 2 collaborations

Mohammed Al-Hashimi 2 collaborations

Hassan S Bazzi 2 collaborations

Raja Dey 2 collaborations

Xin-Yun Huang 2 collaborations

Karsten Suhre 2 collaborations

Khaled Abouhazima 1 collaboration

Khadija KhudaBakhsh 1 collaboration

Mehdi Adeli 1 collaboration

Welathanthrige S Botheju 1 collaboration

Mona L Knapp 1 collaboration

Dalia Alansary 1 collaboration

Vanessa Poth 1 collaboration

Kathrin Förderer 1 collaboration

Frederik Sommer 1 collaboration

David Zimmer 1 collaboration

Yvonne Schwarz 1 collaboration

Nicolas Künzel 1 collaboration

Achim Kless 1 collaboration

Volkhard Helms 1 collaboration

Timo Mühlhaus 1 collaboration

Michael Schroda 1 collaboration

Annette Lis 1 collaboration

Barbara A Niemeyer 1 collaboration

Juan L Rodriguez-Flores 1 collaboration

Radja Messai-Badji 1 collaboration

Amal Robay 1 collaboration

Ramzi Temanni 1 collaboration

Najeeb Syed 1 collaboration

Monika Markovic 1 collaboration

Eiman Al-Khayat 1 collaboration

Fatima Qafoud 1 collaboration

Zafar Nawaz 1 collaboration

Ramin Badii 1 collaboration

Yasser Al-Sarraj 1 collaboration

Hamdi Mbarek 1 collaboration

Wadha Al-Muftah 1 collaboration

Muhammad Alvi 1 collaboration

Mahboubeh R Rostami 1 collaboration

Juan Carlos Martinez Cruzado 1 collaboration

Jason G Mezey 1 collaboration

Alya Al Shakaki 1 collaboration

Joel A Malek 1 collaboration

Matthew B Greenblatt 1 collaboration

Khalid A Fakhro 1 collaboration

Ajayeb Al-Nabet 1 collaboration

Nahla Afifi 1 collaboration

Andrew Brooks 1 collaboration

Said I Ismail 1 collaboration

Asmaa Althani 1 collaboration

Ronald G Crystal 1 collaboration

Ethel Alcantara Adap 1 collaboration

Nelson N Orie 1 collaboration

Fawzi Zghyer 1 collaboration

Sajad Hayat 1 collaboration

Nidal Asaad 1 collaboration

Stefan Worgall 1 collaboration

Vidya Mohamed Ali 1 collaboration

Trayambak Pathak 1 collaboration

Robert Nwokonko 1 collaboration

Maxime F Gueguinou 1 collaboration

Krishna P Subedi 1 collaboration

Yandong Zhou 1 collaboration

Indu S Ambudkar 1 collaboration

Martin T Johnson 1 collaboration

Aparna Gudlur 1 collaboration

Robert M Nwokonko 1 collaboration

Wei Li 1 collaboration

Patrick G Hogan 1 collaboration

Lama Assaf 1 collaboration

Ayat Hammad 1 collaboration

Melanie Fisher 1 collaboration

Mark Terasaki 1 collaboration

Sherif Mostafa 1 collaboration

Rashmi P Kulkarni 1 collaboration

Vimal Ramachandran 1 collaboration

Hani Najafi Shoushtari 1 collaboration

Upendar Reddy Gandra 1 collaboration

Yasser Majeed 1 collaboration

Aisha Y Madani 1 collaboration

Ahmed I Altamimi 1 collaboration

Muneera Vakayil 1 collaboration

Samuel J Fountain 1 collaboration

Nayef A Mazloum 1 collaboration

Murali Prakriya 1 collaboration

Satanay Z Hubrack 1 collaboration

Sumita Chakraborty 1 collaboration

Lu Sun 1 collaboration

Rashmi Kulkarni 1 collaboration

Anja M Billing 1 collaboration

Johannes Graumann 1 collaboration

Stephanie Schaefer-Ramadan 1 collaboration

Maciej Barlog 1 collaboration

Jim Roach 1 collaboration

Cleo Z Reyes 1 collaboration

Lubna Zarif 1 collaboration

Anna Halama 1 collaboration

Sharan Yadav 1 collaboration

Nabeel Attarwala 1 collaboration

Qiuying Chen 1 collaboration

Steven S Gross 1 collaboration

Jawaher Al-Hamaq 1 collaboration

F David Horgen 1 collaboration

Christophe M Raynaud 1 collaboration

Gaurav Thareja 1 collaboration

Abdelaziz Belkadi 1 collaboration

Hesham Al Saloos 1 collaboration

Ayeda Abdulsalam Ahmed 1 collaboration

Saleema C Purayil 1 collaboration

Yasmin A Mohamoud 1 collaboration

Charbel Abi Khalil 1 collaboration

Frank Schmidt 1 collaboration