A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP-modulated NFAT signaling.


Journal

EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049

Informations de publication

Date de publication:
03 02 2022
Historique:
revised: 23 11 2021
received: 26 04 2021
accepted: 07 12 2021
pubmed: 24 12 2021
medline: 15 3 2022
entrez: 23 12 2021
Statut: ppublish

Résumé

Alternative splicing is a potent modifier of protein function. Stromal interaction molecule 1 (Stim1) is the essential activator of store-operated Ca

Identifiants

pubmed: 34942054
doi: 10.15252/embr.202153135
pmc: PMC8892257
doi:

Substances chimiques

Calcium Channels 0
ORAI1 Protein 0
Protein Isoforms 0
Stromal Interaction Molecule 1 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e53135

Informations de copyright

© 2021 The Authors. Published under the terms of the CC BY NC ND 4.0 license.

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Auteurs

Mona L Knapp (ML)

Molecular Biophysics, Saarland University, Homburg, Germany.

Dalia Alansary (D)

Molecular Biophysics, Saarland University, Homburg, Germany.

Vanessa Poth (V)

Molecular Biophysics, Saarland University, Homburg, Germany.

Kathrin Förderer (K)

Molecular Biophysics, Saarland University, Homburg, Germany.

Frederik Sommer (F)

Molecular Biotechnology and Systems Biology, TU Kaiserslautern, Kaiserslautern, Germany.

David Zimmer (D)

Computational Systems Biology, TU Kaiserslautern, Kaiserslautern, Germany.

Yvonne Schwarz (Y)

Molecular Neurophysiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.

Nicolas Künzel (N)

Center for Bioinformatics, Saarland University, Saarbruecken, Germany.

Achim Kless (A)

Grünenthal Innovation, Drug Discovery Technologies, Grünenthal GmbH, Aachen, Germany.

Khaled Machaca (K)

Weill Cornell Medicine, Doha, Qatar.

Volkhard Helms (V)

Center for Bioinformatics, Saarland University, Saarbruecken, Germany.

Timo Mühlhaus (T)

Computational Systems Biology, TU Kaiserslautern, Kaiserslautern, Germany.

Michael Schroda (M)

Molecular Biotechnology and Systems Biology, TU Kaiserslautern, Kaiserslautern, Germany.

Annette Lis (A)

Biophysics, Saarland University, Homburg, Germany.

Barbara A Niemeyer (BA)

Molecular Biophysics, Saarland University, Homburg, Germany.

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Classifications MeSH