Emerging markers of cancer cachexia and their relationship to sarcopenia.
Biomarkers
Cachexia
Hand grip strength
Sarcopenia
Skeletal muscle index
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
08
06
2023
accepted:
06
10
2023
medline:
20
11
2023
pubmed:
31
10
2023
entrez:
31
10
2023
Statut:
ppublish
Résumé
Emerging biomarkers of cancer cachexia and their roles in sarcopenia and prognosis are poorly understood. Baseline assessments of anthropometrics, sarcopenia, cachexia status and biomarkers of cachexia were measured in patients with advanced cancer and healthy controls. Thereafter, relationships of the biomarkers with cachexia and sarcopenia were explored. A prospective case-control design was used, including 40 patients with advanced cancer and 40 gender, age-matched controls. Bioelectrical impedance [skeletal muscle index (SMI)] and hand dynamometry [hand grip strength (HGS)] assessed sarcopenia and a validated tool classified cancer cachexia. Albumin, lymphocyte and platelet counts, haemoglobin, C-reactive protein (CRP), pro-inflammatory cytokines/chemokines and citrullinated histone H3 (H3Cit) were measured. Patients had significantly lower SMI (6.67 kg/m Significant relationships and differences of haemoglobin, CRP and albumin supports future use of these biomarkers in cancer cachexia. CXCL5 and H3Cit as valuable biomarkers in cancer cachexia remains to be defined.
Identifiants
pubmed: 37906352
doi: 10.1007/s00432-023-05465-9
pii: 10.1007/s00432-023-05465-9
pmc: PMC10657295
doi:
Substances chimiques
Biomarkers
0
C-Reactive Protein
9007-41-4
Hemoglobins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17511-17527Informations de copyright
© 2023. The Author(s).
Références
Am J Hosp Palliat Care. 2020 Jul;37(7):565-571
pubmed: 31736322
Adv Exp Med Biol. 2020;1224:1-20
pubmed: 32036601
Front Physiol. 2018 Sep 20;9:1294
pubmed: 30294279
Cytokine. 2015 May;73(1):16-22
pubmed: 25689618
Int J Mol Sci. 2020 Jun 25;21(12):
pubmed: 32630608
Ann Palliat Med. 2019 Jan;8(1):43-49
pubmed: 30685983
J Cancer. 2018 Sep 7;9(18):3295-3302
pubmed: 30271489
PLoS One. 2016 Aug 18;11(8):e0161125
pubmed: 27537502
Exerc Sport Sci Rev. 2010 Oct;38(4):168-76
pubmed: 20871233
Int J Mol Sci. 2021 Mar 12;22(6):
pubmed: 33809200
Transl Oncol. 2018 Apr;11(2):353-357
pubmed: 29448202
Ann Palliat Med. 2019 Jan;8(1):24-32
pubmed: 30525765
J Am Med Dir Assoc. 2020 Mar;21(3):300-307.e2
pubmed: 32033882
JCO Oncol Pract. 2023 Jul;19(7):493-500
pubmed: 37099735
Oncotarget. 2020 Jul 07;11(27):2625-2635
pubmed: 32676164
Cancer Manag Res. 2021 Jan 11;13:181-192
pubmed: 33469362
Am J Med. 2004 Apr 5;116 Suppl 7A:11S-26S
pubmed: 15050883
World J Gastrointest Oncol. 2015 Apr 15;7(4):17-29
pubmed: 25897346
Am J Clin Nutr. 2013 Oct;98(4):1012-9
pubmed: 23966429
J Cachexia Sarcopenia Muscle. 2018 Apr;9(2):306-314
pubmed: 29372594
Eur J Clin Nutr. 2020 Nov;74(11):1519-1535
pubmed: 32366995
Cancer Manag Res. 2018 Oct 25;10:4935-4944
pubmed: 30464594
J Thromb Haemost. 2020 Oct;18(10):2732-2743
pubmed: 32654410
Curr Opin Oncol. 2019 Jul;31(4):286-290
pubmed: 30893144
BMC Cancer. 2014 Nov 16;14:828
pubmed: 25400234
J Clin Oncol. 2015 Jan 1;33(1):90-9
pubmed: 25422490
Cell Metab. 2012 Aug 8;16(2):153-66
pubmed: 22795476
Clin Cancer Res. 2014 Dec 1;20(23):6212-22
pubmed: 25271081
J Cachexia Sarcopenia Muscle. 2015 Dec;6(4):317-24
pubmed: 26672741
PLoS One. 2018 Jan 11;13(1):e0191231
pubmed: 29324871
Support Care Cancer. 2016 Nov;24(11):4495-502
pubmed: 27236439
Oncogene. 2013 Apr 4;32(14):1752-60
pubmed: 22665059
J Cachexia Sarcopenia Muscle. 2020 Jun;11(3):619-635
pubmed: 32142217
Clin Cancer Res. 2016 Aug 15;22(16):3999-4004
pubmed: 27340276
Nutr Cancer. 2017 Jul;69(5):772-779
pubmed: 28524706
J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1316-1329
pubmed: 31419087
J Clin Med. 2018 Dec 01;7(12):
pubmed: 30513776
Support Care Cancer. 2020 Feb;28(2):581-588
pubmed: 31102055
Oncogenesis. 2016 Feb 22;5:e200
pubmed: 26900952
Proc Nutr Soc. 2016 May;75(2):199-211
pubmed: 26786393
Clin Nutr. 2012 Feb;31(1):85-8
pubmed: 21855185
Cancer Cell Int. 2018 May 02;18:68
pubmed: 29743818
Clin Biochem. 2017 Dec;50(18):1281-1288
pubmed: 28739222
Eur J Gastroenterol Hepatol. 2019 Oct;31(10):1220-1227
pubmed: 31498281
Anticancer Res. 2017 Mar;37(3):1281-1287
pubmed: 28314293
Pathobiology. 2019;86(5-6):306-314
pubmed: 31707381
Eur J Surg Oncol. 2018 May;44(5):566-570
pubmed: 29530345
Neoplasma. 2016;63(3):471-6
pubmed: 26952513
Br J Haematol. 2019 Jul;186(2):311-320
pubmed: 30968400
Nat Rev Clin Oncol. 2013 Feb;10(2):90-9
pubmed: 23207794
Cancer Cell. 2018 Jun 11;33(6):965-983
pubmed: 29657130
J Oncol Pract. 2016 Nov;12(11):1163-1171
pubmed: 27858548
J Geriatr Phys Ther. 2009;32(2):83-9
pubmed: 20039588
Cancer Treat Rev. 2017 Nov;60:24-31
pubmed: 28866366
Curr Opin Support Palliat Care. 2018 Dec;12(4):394-403
pubmed: 30102621
Int J Mol Sci. 2020 Mar 17;21(6):
pubmed: 32192002
Curr Opin Support Palliat Care. 2019 Dec;13(4):305-310
pubmed: 31389842