Improved Diffusion Interaction Parameter Measurement to Predict the Viscosity of Concentrated mAb Solutions.
diffusion interaction parameter
high concentration formulation
protein−protein interactions
viscosity
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
04 Dec 2023
04 Dec 2023
Historique:
medline:
5
12
2023
pubmed:
31
10
2023
entrez:
31
10
2023
Statut:
ppublish
Résumé
During the developability assessment of therapeutic monoclonal antibody (mAb) candidates, utilization of robust high-throughput predictive assays enables rapid selection of top candidates with low risks for late-stage development. Predicting the viscosities of highly concentrated mAbs using limited materials is an important aspect of developability assessment because high viscosity can complicate manufacturability, stability, and administration. Here, we report a high-throughput assay measuring protein-protein interactions to predict mAb viscosity. The diffusion interaction parameter (
Identifiants
pubmed: 37906640
doi: 10.1021/acs.molpharmaceut.3c00797
doi:
Substances chimiques
Antibodies, Monoclonal
0
Sodium Chloride
451W47IQ8X
Solutions
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM