Inhalation of acidic nanoparticles prevents doxorubicin cardiotoxicity through improvement of lysosomal function.
autophagy
cardiotoxicity
doxorubicin
lysosomes
nanoparticles
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2023
2023
Historique:
received:
18
05
2023
accepted:
04
08
2023
medline:
2
11
2023
pubmed:
1
11
2023
entrez:
1
11
2023
Statut:
epublish
Résumé
Doxorubicin (Dox) is an effective anticancer molecule, but its clinical efficacy is limited by strong cardiotoxic side effects. Lysosomal dysfunction has recently been proposed as a new mechanism of Dox-induced cardiomyopathy. However, to date, there is a paucity of therapeutic approaches capable of restoring lysosomal acidification and function in the heart.
Identifiants
pubmed: 37908733
doi: 10.7150/thno.86310
pii: thnov13p5435
pmc: PMC10614672
doi:
Substances chimiques
Doxorubicin
80168379AG
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5435-5451Subventions
Organisme : NHLBI NIH HHS
ID : K01 HL159038
Pays : United States
Organisme : NHLBI NIH HHS
ID : R25 HL146166
Pays : United States
Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
Références
Cell Death Differ. 2020 Jun;27(6):1907-1923
pubmed: 31819159
Int J Nanomedicine. 2018 Jan 09;13:319-336
pubmed: 29391792
Arch Toxicol. 2016 Sep;90(9):2063-2076
pubmed: 27342245
Biochem J. 2016 Nov 1;473(21):3769-3789
pubmed: 27487838
Circulation. 2016 Apr 26;133(17):1668-87
pubmed: 26984939
Nanomedicine (Lond). 2016 Mar;11(6):673-92
pubmed: 27003448
Theranostics. 2021 Jul 25;11(17):8550-8569
pubmed: 34373758
Angew Chem Int Ed Engl. 2023 Jun 12;62(24):e202218768
pubmed: 36890113
Adv Drug Deliv Rev. 2007 Aug 10;59(8):748-58
pubmed: 17659804
Cells. 2022 Jun 22;11(13):
pubmed: 35805084
Cardiooncology. 2019 Dec 2;5:18
pubmed: 32154024
Sci Rep. 2019 Feb 14;9(1):2002
pubmed: 30765730
Aging Cell. 2022 Apr;21(4):e13584
pubmed: 35318803
Talanta. 2013 Mar 30;107:408-15
pubmed: 23598242
Mol Cell Biol. 2015 Mar;35(6):956-76
pubmed: 25561470
Autophagy. 2023 Mar;19(3):886-903
pubmed: 35982578
Oxid Med Cell Longev. 2018 Mar 26;2018:8067592
pubmed: 29765503
Cells. 2021 Oct 14;10(10):
pubmed: 34685734
Chem Biol. 1999 Jul;6(7):411-8
pubmed: 10381401
Curr Cardiol Rep. 2013 May;15(5):362
pubmed: 23512625
Annu Rev Pharmacol Toxicol. 2012;52:481-503
pubmed: 22035254
Sci Transl Med. 2018 Jan 17;10(424):
pubmed: 29343624
Aging Cell. 2018 Oct;17(5):e12811
pubmed: 30003648
Circulation. 2018 Aug 14;138(7):696-711
pubmed: 29348263
Adv Mater. 2009;21:419-424
pubmed: 19606281
J Am Heart Assoc. 2019 Feb 19;8(4):e010866
pubmed: 30773991
Science. 2017 Nov 10;358(6364):807-813
pubmed: 29074583
J Nanobiotechnology. 2018 Oct 31;16(1):85
pubmed: 30382919
Antioxid Redox Signal. 2016 Jul 1;25(1):10-27
pubmed: 26959532
Nat Chem Biol. 2023 Jun 15;:
pubmed: 37322156
Int J Mol Sci. 2023 Jan 22;24(3):
pubmed: 36768500
Pharmacol Res. 2022 Apr;178:106186
pubmed: 35306141
Adv Exp Med Biol. 2014;801:105-11
pubmed: 24664687
Autophagy. 2016;12(3):472-83
pubmed: 26761717
Oncotarget. 2017 Jul 11;8(28):46663-46680
pubmed: 28445146
Pharmaceutics. 2021 Jan 22;13(2):
pubmed: 33499150
Adv Drug Deliv Rev. 2023 Jun;197:114828
pubmed: 37075952
RSC Adv. 2020 Jan 27;10(8):4218-4231
pubmed: 35495261
J Clin Oncol. 2007 Feb 10;25(5):493-500
pubmed: 17290056
Biomed Pharmacother. 2021 Jul;139:111708
pubmed: 34243633
Biomaterials. 2022 Feb;281:121368
pubmed: 35030436
Mol Pharmacol. 2019 Aug;96(2):219-232
pubmed: 31164387
J Biomed Nanotechnol. 2016 May;12(5):863-77
pubmed: 27305811