Development of a Gadolinium-Boron-Conjugated Albumin for MRI-Guided Neutron Capture Therapy.

Mice Animals Boron Gadolinium Tissue Distribution Neoplasms / diagnostic imaging Neutron Capture Therapy / methods Magnetic Resonance Imaging / methods Boron Neutron Capture Therapy / methods Maleimides
MRI albumin boron neutron capture therapy closo-dodecaborate gadolinium contrast agents

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
04 Dec 2023
Historique:
medline: 5 12 2023
pubmed: 1 11 2023
entrez: 1 11 2023
Statut: ppublish

Résumé

Noninvasive monitoring of boron agent biodistribution is required in advance of neutron capture therapy. In this study, we developed a gadolinium-boron-conjugated albumin (Gd-MID-BSA) for MRI-guided neutron capture therapy. Gd-MID-BSA was prepared by labeling bovine serum albumin with a maleimide-functionalized gadolinium complex and a maleimide-functionalized

Identifiants

DOI: 10.1021/acs.molpharmaceut.3c00726 PMID: 37909734
pubmed: 37909734
doi: 10.1021/acs.molpharmaceut.3c00726
doi:

Substances chimiques

Boron N9E3X5056Q
Gadolinium AU0V1LM3JT
Maleimides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6311-6318

Auteurs

Satoshi Okada (S)

Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan.
School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan.
ORCID: 0000-0003-2776-9509

Kai Nishimura (K)

School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan.

Qarri Ainaya (Q)

School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan.

Kouichi Shiraishi (K)

Division of Medical Engineering, Research Center for Medical Sciences, The Jikei University School of Medicine, 163-1 Kashiwashita, Kashiwa, Chiba 277-8567, Japan.

Sergey A Anufriev (SA)

A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119334 Moscow, Russia.

Igor B Sivaev (IB)

A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Str., 119334 Moscow, Russia.
ORCID: 0000-0002-5442-367X

Yoshinori Sakurai (Y)

Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-nishi, Kumatori, Sennan, Osaka 590-0494, Japan.
ORCID: 0000-0001-9404-4255

Minoru Suzuki (M)

Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-nishi, Kumatori, Sennan, Osaka 590-0494, Japan.
ORCID: 0000-0002-5421-9417

Masayuki Yokoyama (M)

Division of Medical Engineering, Research Center for Medical Sciences, The Jikei University School of Medicine, 163-1 Kashiwashita, Kashiwa, Chiba 277-8567, Japan.
ORCID: 0000-0001-6053-1856

Hiroyuki Nakamura (H)

Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan.
School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan.
ORCID: 0000-0002-4511-2984

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Development of a Gadolinium-Boron-Conjugated...
questionsmedicales.fr › Eucaryotes › Animaux › Development of a Gadolinium-Boron-Conjugated...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Métalloïdes › Bore › Development of a Gadolinium-Boron-Conjugated...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Terres rares › Lanthanides › Gadolinium › Development of a Gadolinium-Boron-Conjugated...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Development of a Gadolinium-Boron-Conjugated...
questionsmedicales.fr › Tumeurs › Development of a Gadolinium-Boron-Conjugated...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie de haute énergie › Thérapie par capture de neutrons › Development of a Gadolinium-Boron-Conjugated...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Development of a Gadolinium-Boron-Conjugated...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie de haute énergie › Thérapie par capture de neutrons › Thérapie par capture de neutrons par le bore › Development of a Gadolinium-Boron-Conjugated...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrroles › Maléimides › Development of a Gadolinium-Boron-Conjugated...