Nomogram for predicting opioid-induced nausea and vomiting for cancer pain patients.
Cancer
Nomogram
Opioid-induced nausea and vomiting (OINV)
Predictive model
Risk factors
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
02 Nov 2023
02 Nov 2023
Historique:
received:
11
07
2023
accepted:
24
10
2023
medline:
3
11
2023
pubmed:
2
11
2023
entrez:
2
11
2023
Statut:
epublish
Résumé
Opioid-induced nausea and vomiting are frequently observed as an adverse effect in the treatment of cancer-related pain. The factors that affect OINV in cancer patients remain unclear. In this study, we developed a nomogram for predicting the occurrence of OINV in this population using retrospective clinical data. We collected data from 416 cancer pain patients, 70% of whom used the training set to analyze demographic and clinical variables. We used multivariate logistic regression to identify significant factors associated with OINV. Then, we construct a prediction nomogram. The validation set comprises the remaining 30%. The reliability of the nomogram is evaluated by bootstrap resampling. Using multivariate logistic regression, we identified five significant factors associated with OINV. The C-index was 0.835 (95% confidence interval [CI], 0.828-0.842) for the training set and 0.810 (95% CI, 0.793-0.826) for the validation set. The calibrated curves show a good agreement between the predicted and actual occurrence of OINV. In a retrospective study based on five saliency-found variables, we developed and proved a reliable nomogram model to predict OINV in cancer pain patients. Future prospective studies should assess the model's reliability and usefulness in clinical practice.
Identifiants
pubmed: 37914831
doi: 10.1007/s00520-023-08144-0
pii: 10.1007/s00520-023-08144-0
pmc: PMC10620250
doi:
Substances chimiques
Analgesics, Opioid
0
Antiemetics
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
663Subventions
Organisme : National Natural Science Foundation of China
ID : 81702678
Organisme : National Natural Science Foundation of China
ID : 82103045
Organisme : Beijing Xisike Clinical Oncology Research Foundation
ID : Y-XD202001-0332
Informations de copyright
© 2023. The Author(s).
Références
Bray F, Laversanne M, Weiderpass E, Soerjomataram I (2021) The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer. 127(16):3029–3030. https://doi.org/10.1002/cncr.33587
doi: 10.1002/cncr.33587
pubmed: 34086348
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 71(3):209–249. https://doi.org/10.3322/caac.21660
doi: 10.3322/caac.21660
pubmed: 33538338
Zhu C, Ma H, He A, Li Y, He C, Xia Y (2022) Exercise in cancer prevention and anticancer therapy: Efficacy, molecular mechanisms and clinical information. Cancer Lett. 544:215814. https://doi.org/10.1016/j.canlet.2022.215814
doi: 10.1016/j.canlet.2022.215814
pubmed: 35803475
Bharti R, Dey G, Lin F, Lathia J, Reizes O (2022) CD55 in cancer: Complementing functions in a non-canonical manner. Cancer Lett. 551:215935. https://doi.org/10.1016/j.canlet.2022.215935
doi: 10.1016/j.canlet.2022.215935
pubmed: 36216147
Yu S, Li W, Tang L, Fan X, Yao S, Zhang X, Bi Z, Cheng H (2022) Depression in breast cancer patients: Immunopathogenesis and immunotherapy. Cancer Lett. 536:215648. https://doi.org/10.1016/j.canlet.2022.215648
doi: 10.1016/j.canlet.2022.215648
pubmed: 35307487
van den Beuken-van Everdingen MH, Hochstenbach LM, Joosten EA, Tjan-Heijnen VC, Janssen DJ (2016) Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J Pain Symptom Manage. 51(6):1070-1090 e9. https://doi.org/10.1016/j.jpainsymman.2015.12.340
doi: 10.1016/j.jpainsymman.2015.12.340
pubmed: 27112310
Laugsand EA, Fladvad T, Skorpen F, Maltoni M, Kaasa S, Fayers P, Klepstad P (2011) Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids. Eur J Cancer 47(11):1682–91. https://doi.org/10.1016/j.ejca.2011.04.014
doi: 10.1016/j.ejca.2011.04.014
pubmed: 21570824
Sande TA, Laird BJA, Fallon MT (2019) The management of opioid-induced nausea and vomiting in patients with cancer: a systematic review. J Palliat Med 22(1):90–97. https://doi.org/10.1089/jpm.2018.0260
doi: 10.1089/jpm.2018.0260
pubmed: 30239277
Cepeda MS, Farrar JT, Baumgarten M, Boston R, Carr DB, Strom BL (2003) Side effects of opioids during short-term administration: effect of age, gender, and race. Clin Pharmacol Ther 74(2):102–12. https://doi.org/10.1016/S0009-9236(03)00152-8
doi: 10.1016/S0009-9236(03)00152-8
pubmed: 12891220
Quigley C (2005) The role of opioids in cancer pain. BMJ 331(7520):825–829. https://doi.org/10.1136/bmj.331.7520.825
doi: 10.1136/bmj.331.7520.825
pubmed: 16210282
pmcid: 1246085
Coluzzi F, Rocco A, Mandatori I, Mattia C (2012) Non-analgesic effects of opioids: opioid-induced nausea and vomiting: mechanisms and strategies for their limitation. Curr Pharm Des. 18(37):6043–52. https://doi.org/10.2174/138161212803582540
doi: 10.2174/138161212803582540
pubmed: 22747538
Laugsand EA, Kaasa S, Klepstad P (2011) Management of opioid-induced nausea and vomiting in cancer patients: systematic review and evidence-based recommendations. Palliat Med 25(5):442–53. https://doi.org/10.1177/0269216311404273
doi: 10.1177/0269216311404273
pubmed: 21708851
McNicol E, Horowicz-Mehler N, Fisk RA, Bennett K, Gialeli-Goudas M, Chew PW, Lau J, Carr D, Americal Pain S (2003) Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review. J Pain. 4(5):231–56. https://doi.org/10.1016/s1526-5900(03)00556-x
doi: 10.1016/s1526-5900(03)00556-x
pubmed: 14622694
Kanbayashi Y, Hosokawa T (2014) Predictive factors for nausea or vomiting in patients with cancer who receive oral oxycodone for the first time: is prophylactic medication for prevention of opioid-induced nausea or vomiting necessary? J Palliat Med. 17(6):683–7. https://doi.org/10.1089/jpm.2013.0613
doi: 10.1089/jpm.2013.0613
pubmed: 24702605
Sato J, Tanaka R, Ishikawa H, Suzuki T, Shino M (2020) A preliminary study of the effect of naldemedine tosylate on opioid-induced nausea and vomiting. Support Care Cancer. 28(3):1083–1088. https://doi.org/10.1007/s00520-019-04884-0
doi: 10.1007/s00520-019-04884-0
pubmed: 31183560
Ogawa Y, Kurihara T, Sakurai M, Monma M, Nakayama H, Higuchi H, Kogo M, Kiuchi Y (2021) Predictive factors of opioid-induced nausea in cancer patients. J Pain Palliat Care Pharmacother. 35(1):7–12. https://doi.org/10.1080/15360288.2020.1829250
doi: 10.1080/15360288.2020.1829250
pubmed: 33320697
Zhang Q, Ouyang H, Ye F, Chen S, Xie L, Zhao X, Yu X (2020) Multiple mathematical models of diffusion-weighted imaging for endometrial cancer characterization: correlation with prognosis-related risk factors. Eur J Radiol. 130:109102. https://doi.org/10.1016/j.ejrad.2020.109102
doi: 10.1016/j.ejrad.2020.109102
pubmed: 32673928
Kattan MW, Scardino PT (2007) Evidence for the usefulness of nomograms. Nat Clin Pract Urol. 4(12):638–9. https://doi.org/10.1038/ncpuro0968
doi: 10.1038/ncpuro0968
pubmed: 17984994
Kattan MW (2002) Nomograms. Introduction Semin Urol Oncol 20(2):79–81
pubmed: 12030248
Li Q, Jiang T, Zhang C, Zhang Y, Huang Z, Zhou H, Huang P (2022) A nomogram based on clinical information, conventional ultrasound and radiomics improves prediction of malignant parotid gland lesions. Cancer Lett 527:107–114. https://doi.org/10.1016/j.canlet.2021.12.015
doi: 10.1016/j.canlet.2021.12.015
pubmed: 34929334
Alba AC, Agoritsas T, Walsh M, Hanna S, Iorio A, Devereaux PJ, McGinn T, Guyatt G (2017) Discrimination and calibration of clinical prediction models: users’ guides to the medical literature. JAMA. 318(14):1377–1384. https://doi.org/10.1001/jama.2017.12126
doi: 10.1001/jama.2017.12126
pubmed: 29049590
Zheng X, He X (2023) Development of a nomogram for the prediction of complicated appendicitis during pregnancy. BMC Surg. 23(1):188. https://doi.org/10.1186/s12893-023-02064-w
doi: 10.1186/s12893-023-02064-w
pubmed: 37393302
pmcid: 10315032
Vickers AJ, Elkin EB (2006) Decision curve analysis: a novel method for evaluating prediction models. Med Decis Making. 26(6):565–74. https://doi.org/10.1177/0272989X06295361
doi: 10.1177/0272989X06295361
pubmed: 17099194
pmcid: 2577036
Corli O, Santucci C, Corsi N, Radrezza S, Galli F, Bosetti C (2019) The burden of opioid adverse events and the influence on cancer patients’ symptomatology. J Pain Symptom Manage. 57(5):899-908 e6. https://doi.org/10.1016/j.jpainsymman.2019.02.009
doi: 10.1016/j.jpainsymman.2019.02.009
pubmed: 30776537
Tsukuura H, Miyazaki M, Morita T, Sugishita M, Kato H, Murasaki Y, Gyawali B, Kubo Y, Ando M, Kondo M, Yamada K, Hasegawa Y, Ando Y (2018) Efficacy of Prophylactic Treatment for Oxycodone-Induced Nausea and Vomiting Among Patients with Cancer Pain (POINT): A Randomized, Placebo-Controlled Double-Blind Trial. Oncologist 23(3):367–374. https://doi.org/10.1634/theoncologist.2017-0225
doi: 10.1634/theoncologist.2017-0225
pubmed: 29038236
Walsh D, Davis M, Ripamonti C, Bruera E, Davies A, Molassiotis A (2017) 2016 Updated MASCC/ESMO consensus recommendations: Management of nausea and vomiting in advanced cancer. Support Care Cancer. 25(1):333–340. https://doi.org/10.1007/s00520-016-3371-3
doi: 10.1007/s00520-016-3371-3
pubmed: 27534961
Ukai T, Ebihara G, Watanabe M (2018) Opioid administration via epidural catheter is a risk factor for postoperative nausea and vomiting in total hip arthroplasty: A retrospective study. J Orthop Sci. 23(6):973–976. https://doi.org/10.1016/j.jos.2018.06.011
doi: 10.1016/j.jos.2018.06.011
pubmed: 30431008
Molassiotis A, Stamataki Z, Kontopantelis E (2013) Development and preliminary validation of a risk prediction model for chemotherapy-related nausea and vomiting. Support Care Cancer. 21(10):2759–67. https://doi.org/10.1007/s00520-013-1843-2
doi: 10.1007/s00520-013-1843-2
pubmed: 23715816
Jung D, Lee KM, Kim WH, Lee JY, Kim TY, Im SA, Lee KH, Spiegel D, Hahm BJ (2016) Longitudinal association of poor sleep quality with chemotherapy-induced nausea and vomiting in patients with breast cancer. Psychosom Med. 78(8):959–965. https://doi.org/10.1097/PSY.0000000000000372
doi: 10.1097/PSY.0000000000000372
pubmed: 27428859
Huang XJ, Li XY, Li JH, Hu ZY, Luo L, Tan Y, Chen HY, Fan RR, Wang TY, Meng LQ, Wei T (2021) Nomogram for predicting chemotherapy-induced nausea and vomiting for breast cancer patients. Tohoku J Exp Med. 254(2):111–121. https://doi.org/10.1620/tjem.254.111
doi: 10.1620/tjem.254.111
pubmed: 34162779
Dranitsaris G, Molassiotis A, Clemons M, Roeland E, Schwartzberg L, Dielenseger P, Jordan K, Young A, Aapro M (2017) The development of a prediction tool to identify cancer patients at high risk for chemotherapy-induced nausea and vomiting. Ann Oncol. 28(6):1260–1267. https://doi.org/10.1093/annonc/mdx100
doi: 10.1093/annonc/mdx100
pubmed: 28398530
pmcid: 5452068
Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM, Tischfield JA, Kreek MJ, Yu L (1998) Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A. 95(16):9608–13. https://doi.org/10.1073/pnas.95.16.9608
doi: 10.1073/pnas.95.16.9608
pubmed: 9689128
pmcid: 21386