iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer.

Animals Humans Mice Brain / cytology Cell Differentiation Induced Pluripotent Stem Cells / cytology Microglia / cytology Neurogenesis Organoids / cytology Cholesterol / metabolism Neural Stem Cells / cytology Axons Cell Proliferation Esters / metabolism Lipid Droplets / metabolism

Journal

Nature

ISSN: 1476-4687

Titre abrégé: Nature

Pays: England

ID NLM: 0410462

Informations de publication

Date de publication:
Nov 2023

Historique:

received: 18 03 2021

accepted: 04 10 2023

medline: 9 11 2023

pubmed: 2 11 2023

entrez: 2 11 2023

Statut: ppublish

Résumé

Microglia are specialized brain-resident macrophages that arise from primitive macrophages colonizing the embryonic brain

Identifiants

DOI: 10.1038/s41586-023-06713-1 PMID: 37914940

pubmed: 37914940

doi: 10.1038/s41586-023-06713-1

pii: 10.1038/s41586-023-06713-1

doi:

Substances chimiques

Cholesterol 97C5T2UQ7J

PLIN2 protein, human 0

Esters 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

397-405

Informations de copyright

Références

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