An atlas of genetic determinants of forearm fracture.

Animals Mice Forearm Genome-Wide Association Study Fractures, Bone / genetics Bone Density / genetics Risk Factors

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
Nov 2023
Historique:
received: 27 01 2023
accepted: 13 09 2023
medline: 10 11 2023
pubmed: 3 11 2023
entrez: 3 11 2023
Statut: ppublish

Résumé

Osteoporotic fracture is among the most common and costly of diseases. While reasonably heritable, its genetic determinants have remained elusive. Forearm fractures are the most common clinically recognized osteoporotic fractures with a relatively high heritability. To establish an atlas of the genetic determinants of forearm fractures, we performed genome-wide association analyses including 100,026 forearm fracture cases. We identified 43 loci, including 26 new fracture loci. Although most fracture loci associated with bone mineral density, we also identified loci that primarily regulate bone quality parameters. Functional studies of one such locus, at TAC4, revealed that Tac4

Identifiants

DOI: 10.1038/s41588-023-01527-3 PMID: 37919453 PMC: PMC10632131
pubmed: 37919453
doi: 10.1038/s41588-023-01527-3
pii: 10.1038/s41588-023-01527-3
pmc: PMC10632131
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1820-1830

Subventions

Organisme : IngaBritt och Arne Lundbergs Forskningsstiftelse (Ingabritt and Arne Lundberg Research Foundation)
ID : LU2021-0096
Organisme : IngaBritt och Arne Lundbergs Forskningsstiftelse (Ingabritt and Arne Lundberg Research Foundation)
ID : LU2017-0081
Organisme : Novo Nordisk Fonden (Novo Nordisk Foundation)
ID : NNF 190C0055250
Organisme : Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation)
ID : KAW 2015.0317
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : K20006-72X-20155013
Organisme : Kempestiftelserna (Kempe Foundations)
ID : JCK-1021

Informations de copyright

© 2023. The Author(s).

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Auteurs

Maria Nethander (M)

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0003-3688-906X

Sofia Movérare-Skrtic (S)

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0001-7982-7438

Anders Kämpe (A)

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-1829-3855

Eivind Coward (E)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Ene Reimann (E)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-5410-4433

Louise Grahnemo (L)

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0001-5276-6612

Éva Borbély (É)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
National Laboratory for Drug Research and Development, Budapest, Hungary.

Zsuzsanna Helyes (Z)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
National Laboratory for Drug Research and Development, Budapest, Hungary.
Eotvos Lorand Research Network, Chronic Pain Research Group, University of Pécs, Pécs, Hungary.

Thomas Funck-Brentano (T)

BIOSCAR UMRS 1132, Université Paris Diderot, Sorbonne Paris Cité, INSERM, Paris, France.

Martine Cohen-Solal (M)

BIOSCAR UMRS 1132, Université Paris Diderot, Sorbonne Paris Cité, INSERM, Paris, France.
ORCID: 0000-0002-8582-8258

Juha Tuukkanen (J)

Department of Anatomy and Cell Biology, Faculty of Medicine, Institute of Cancer Research and Translational Medicine, University of Oulu, Oulu, Finland.
ORCID: 0000-0002-1723-6461

Antti Koskela (A)

Department of Anatomy and Cell Biology, Faculty of Medicine, Institute of Cancer Research and Translational Medicine, University of Oulu, Oulu, Finland.

Jianyao Wu (J)

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Lei Li (L)

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Tianyuan Lu (T)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.
ORCID: 0000-0002-5664-5698

Maiken E Gabrielsen (ME)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Reedik Mägi (R)

Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-2964-6011

Mari Hoff (M)

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Rheumatology, St Olavs Hospital, Trondheim, Norway.

Ulf H Lerner (UH)

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Petra Henning (P)

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Henrik Ullum (H)

Statens Serum Institut, Copenhagen, Denmark.

Christian Erikstrup (C)

Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
ORCID: 0000-0001-6551-6647

Søren Brunak (S)

Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-0316-5866

Arnulf Langhammer (A)

Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
ORCID: 0000-0001-5296-6673

Tiinamaija Tuomi (T)

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Folkhälsan Research Center, Helsinki, Finland.
Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Department of Endocrinology, Abdominal Center, Helsinki University Hospital, Helsinki, Finland.
Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-8306-6202

Asmundur Oddsson (A)

deCODE genetics, Reykjavik, Iceland.
ORCID: 0000-0002-4606-5163

Kari Stefansson (K)

deCODE genetics, Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Ulrika Pettersson-Kymmer (U)

Department of Integrative Medical Biology, Clinical Pharmacology, Umea University, Umea, Sweden.

Sisse Rye Ostrowski (SR)

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Immunology, Copenhagen Hospital Biobank Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0001-5288-3851

Ole Birger Vesterager Pedersen (OBV)

Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Immunology, Zealand University Hospital, Koege, Denmark.
ORCID: 0000-0003-2312-5976

Unnur Styrkarsdottir (U)

deCODE genetics, Reykjavik, Iceland.

Outi Mäkitie (O)

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Folkhälsan Institute of Genetics, Helsinki, Finland.
Children's Hospital and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0002-4547-001X

Kristian Hveem (K)

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, and Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.

J Brent Richards (JB)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.
Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
ORCID: 0000-0002-3746-9086

Claes Ohlsson (C)

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. claes.ohlsson@medic.gu.se.
Region Västra Götaland, Sahlgrenska University Hospital, Department of Drug Treatment, Gothenburg, Sweden. claes.ohlsson@medic.gu.se.
ORCID: 0000-0002-9633-2805

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › An atlas of genetic determinants of forearm fracture.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › An atlas of genetic determinants of forearm fracture.
questionsmedicales.fr › Régions du corps › Membres › Membre supérieur › Avant-bras › An atlas of genetic determinants of forearm fracture.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › An atlas of genetic determinants of forearm fracture.
questionsmedicales.fr › Plaies et blessures › Fractures osseuses › An atlas of genetic determinants of forearm fracture.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Densité osseuse › An atlas of genetic determinants of forearm fracture.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › An atlas of genetic determinants of forearm fracture.