Intestinal flora altered and correlated with interleukin-2/4 in patients with primary immune thrombocytopenia.
16S rRNA
IL-2
IL-4
Primary immune thrombocytopenia
Th1/Th2 imbalance
intestinal flora
metagenomics
Journal
Hematology (Amsterdam, Netherlands)
ISSN: 1607-8454
Titre abrégé: Hematology
Pays: England
ID NLM: 9708388
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
medline:
6
11
2023
pubmed:
3
11
2023
entrez:
3
11
2023
Statut:
ppublish
Résumé
Little is known about the changes and mechanisms of intestinal flora in primary immune thrombocytopenia (ITP) patients. To explore the structural and functional differences of intestinal flora between ITP patients and healthy controls, and clarify the correlation between intestinal flora and Th1/Th2 imbalance. Feces from ITP patients and healthy controls were studied by 16S rRNA and metagenomic techniques at phylum, genus, species or functional levels. Blood samples were collected for the detection of interleukin -2 (IL-2) and IL-4 concentrations. The following changes in ITP patients were found: a decrease of Bacteroidetes phylum, an increase of Proteobacteria phylum and alterations of ten genera and 1045 species. IL-2 and IL-4 were significantly correlated with six and five genera, respectively. Species of The mechanism underlying functional and structural changes of intestinal flora in ITP patients may be related to inflammation and immunity, providing possibilities of probiotics or fecal transplants for ITP.
Sections du résumé
BACKGROUND
UNASSIGNED
Little is known about the changes and mechanisms of intestinal flora in primary immune thrombocytopenia (ITP) patients.
AIM
UNASSIGNED
To explore the structural and functional differences of intestinal flora between ITP patients and healthy controls, and clarify the correlation between intestinal flora and Th1/Th2 imbalance.
METHODS
UNASSIGNED
Feces from ITP patients and healthy controls were studied by 16S rRNA and metagenomic techniques at phylum, genus, species or functional levels. Blood samples were collected for the detection of interleukin -2 (IL-2) and IL-4 concentrations.
RESULTS
UNASSIGNED
The following changes in ITP patients were found: a decrease of Bacteroidetes phylum, an increase of Proteobacteria phylum and alterations of ten genera and 1045 species. IL-2 and IL-4 were significantly correlated with six and five genera, respectively. Species of
CONCLUSION
UNASSIGNED
The mechanism underlying functional and structural changes of intestinal flora in ITP patients may be related to inflammation and immunity, providing possibilities of probiotics or fecal transplants for ITP.
Identifiants
pubmed: 37921501
doi: 10.1080/16078454.2023.2277501
doi:
Substances chimiques
Interleukin-2
0
Interleukin-4
207137-56-2
RNA, Ribosomal, 16S
0
IL2 protein, human
0
IL4 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM