IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
03 11 2023
03 11 2023
Historique:
received:
26
05
2023
accepted:
25
10
2023
medline:
6
11
2023
pubmed:
4
11
2023
entrez:
4
11
2023
Statut:
epublish
Résumé
In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue, and is proposed to be competent for forward transmission. The interaction between parasites, adipose tissue, and the local immune system is likely to drive the adipose tissue wasting and weight loss observed in cattle and humans infected with T. brucei. However, mechanistically, events leading to subcutaneous white adipose tissue wasting are not fully understood. Here, using several complementary approaches, including mass cytometry by time of flight, bulk and single cell transcriptomics, and in vivo genetic models, we show that T. brucei infection drives local expansion of several IL-17A-producing cells in the murine WAT, including T
Identifiants
pubmed: 37923768
doi: 10.1038/s41467-023-42918-8
pii: 10.1038/s41467-023-42918-8
pmc: PMC10624677
doi:
Substances chimiques
Interleukin-17
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7070Subventions
Organisme : Medical Research Council
ID : MR/W018497/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK125281
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK097441
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK127575
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
Exp Parasitol. 1976 Dec;40(3):427-31
pubmed: 976425
Horm Metab Res. 1999 Dec;31(12):626-31
pubmed: 10668912
Cells. 2022 Jan 11;11(2):
pubmed: 35053354
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Nat Rev Rheumatol. 2013 Jun;9(6):375-9
pubmed: 23229447
PLoS Negl Trop Dis. 2018 Aug 15;12(8):e0006690
pubmed: 30110342
J Insect Physiol. 2015 Nov;82:28-32
pubmed: 26301521
J Immunol. 2010 Dec 1;185(11):6947-59
pubmed: 21037091
Sci Rep. 2015 Dec 10;5:18176
pubmed: 26658723
FEBS J. 2020 Aug;287(16):3350-3369
pubmed: 32255251
Nat Commun. 2023 Aug 29;14(1):5279
pubmed: 37644007
Front Nutr. 2016 Apr 19;3:10
pubmed: 27148535
Adipocyte. 2020 Dec;9(1):472-483
pubmed: 32772766
J Immunother Cancer. 2021 Oct;9(10):
pubmed: 34642245
Nat Immunol. 2018 May;19(5):464-474
pubmed: 29670241
Infect Immun. 2010 Dec;78(12):5271-9
pubmed: 20855512
Cell Host Microbe. 2016 Jun 8;19(6):837-48
pubmed: 27237364
Nat Methods. 2020 Feb;17(2):159-162
pubmed: 31819264
Br J Cancer. 2010 May 11;102(10):1541-8
pubmed: 20407445
Nat Med. 2017 Dec;23(12):1454-1465
pubmed: 29131158
Elife. 2019 Oct 23;8:
pubmed: 31644425
Methods Enzymol. 2014;538:171-93
pubmed: 24529439
Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E547-55
pubmed: 15507534
Am J Physiol Regul Integr Comp Physiol. 2011 Aug;301(2):R285-96
pubmed: 21490370
Cell. 2019 Apr 4;177(2):399-413.e12
pubmed: 30853215
Nat Immunol. 2015 Mar;16(3):296-305
pubmed: 25642821
Endocrinology. 1990 Feb;126(2):1229-34
pubmed: 2153523
PLoS Biol. 2012;10(11):e1001433
pubmed: 23209378
Br J Pharmacol. 2021 May;178(10):2096-2110
pubmed: 32627171
Cell Rep. 2018 Nov 20;25(8):2044-2052.e5
pubmed: 30463003
J Neurol. 2019 Sep;266(9):2334-2337
pubmed: 31209574
PLoS Negl Trop Dis. 2017 Oct 26;11(10):e0006002
pubmed: 29073144
Science. 2019 Apr 26;364(6438):
pubmed: 31023895
Trends Immunol. 2022 Mar;43(3):210-229
pubmed: 35090788
Nat Commun. 2021 Nov 25;12(1):6843
pubmed: 34824268
Elife. 2020 Nov 02;9:
pubmed: 33136000
Int J Clin Exp Pathol. 2015 Sep 01;8(9):11100-7
pubmed: 26617829
Sci Rep. 2017 Aug 21;7(1):8906
pubmed: 28827714
J Immunol. 2007 Oct 15;179(8):5462-73
pubmed: 17911633
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
J Clin Invest. 2010 Oct;120(10):3466-79
pubmed: 20877011
Trends Immunol. 2006 Jun;27(6):255-60
pubmed: 16679063
Nature. 2020 Feb;578(7796):610-614
pubmed: 32076265
Nature. 2018 Jul;559(7712):103-108
pubmed: 29925944
Acta Pharm Sin B. 2022 Apr;12(4):1840-1855
pubmed: 35847488
Brain Behav Immun. 2020 Jul;87:272-285
pubmed: 31863824
Nat Rev Immunol. 2016 Oct;16(10):626-38
pubmed: 27546235
J Invest Dermatol. 2009 Jul;129(7):1628-42
pubmed: 19262602
Annu Rev Nutr. 2007;27:79-101
pubmed: 17313320
Nat Metab. 2021 Apr;3(4):496-512
pubmed: 33859430
PLoS Negl Trop Dis. 2017 Jun 1;11(6):e0005438
pubmed: 28570558
Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165706
pubmed: 31987839
Elife. 2016 Sep 22;5:
pubmed: 27653219
Infect Immun. 2006 Jun;74(6):3190-203
pubmed: 16714546
Commun Biol. 2020 May 14;3(1):237
pubmed: 32409640
PLoS Pathog. 2021 Sep 15;17(9):e1009933
pubmed: 34525131
Nat Rev Immunol. 2022 May;22(5):309-321
pubmed: 34608281
J Clin Invest. 1992 May;89(5):1610-7
pubmed: 1569199
Immunity. 2020 Jun 16;52(6):1039-1056.e9
pubmed: 32392463
Nat Microbiol. 2023 Oct 12;:
pubmed: 37828246
Immunity. 2012 Jul 27;37(1):48-59
pubmed: 22770884
PLoS Pathog. 2012;8(4):e1002641
pubmed: 22496659
JAMA. 2021 Jun 15;325(23):2402
pubmed: 34129004
Front Immunol. 2022 Oct 13;13:1005551
pubmed: 36311783
Nature. 1997 May 1;387(6628):90-4
pubmed: 9139827
Clin Transl Med. 2023 Feb;13(2):e1199
pubmed: 36808888
Lancet Neurol. 2013 Feb;12(2):186-94
pubmed: 23260189
PLoS Pathog. 2021 Nov 11;17(11):e1010026
pubmed: 34762705
Nature. 2022 Mar;603(7903):926-933
pubmed: 35296864
Nat Immunol. 2023 Apr;24(4):714-728
pubmed: 36928414
Nat Commun. 2022 Sep 30;13(1):5752
pubmed: 36180478
Front Cell Dev Biol. 2020 Feb 12;8:33
pubmed: 32117967
Front Endocrinol (Lausanne). 2016 Apr 13;7:30
pubmed: 27148161
Infect Immun. 2008 Sep;76(9):4206-13
pubmed: 18591228
Arthritis Rheumatol. 2016 Mar;68(3):679-89
pubmed: 26473967
PLoS Negl Trop Dis. 2010 Feb 16;4(2):e604
pubmed: 20169058
J Exp Med. 2023 Feb 6;220(2):
pubmed: 36480166
Clin Microbiol Infect. 2011 Jul;17(7):986-95
pubmed: 21722252
Ann Soc Belg Med Trop. 1977;57(4-5):369-81
pubmed: 610616
Cell Rep. 2021 Sep 21;36(12):109741
pubmed: 34551286