Lung UltrasouNd Guided surfactant therapy in preterm infants: an international multicenter randomized control trial (LUNG study).
Humans
Infant, Newborn
Bronchopulmonary Dysplasia
/ prevention & control
Continuous Positive Airway Pressure
/ adverse effects
Infant, Premature
Lung
/ diagnostic imaging
Oxygen
/ therapeutic use
Pulmonary Surfactants
/ therapeutic use
Respiratory Distress Syndrome, Newborn
/ therapy
Surface-Active Agents
/ therapeutic use
Ultrasonography, Interventional
Lung ultrasound
Preterm infants
Respiratory distress syndrome
Surfactant therapy
Journal
Trials
ISSN: 1745-6215
Titre abrégé: Trials
Pays: England
ID NLM: 101263253
Informations de publication
Date de publication:
04 Nov 2023
04 Nov 2023
Historique:
received:
19
05
2023
accepted:
24
10
2023
medline:
6
11
2023
pubmed:
5
11
2023
entrez:
5
11
2023
Statut:
epublish
Résumé
The management of respiratory distress syndrome (RDS) in premature newborns is based on different types of non-invasive respiratory support and on surfactant replacement therapy (SRT) to avoid mechanical ventilation as it may eventually result in lung damage. European guidelines currently recommend SRT only when the fraction of inspired oxygen (FiO In this study, 668 spontaneously-breathing preterm infants, born at 25 Based on previous published studies, it seems that LUS may decrease the time to administer surfactant therapy. It is known that early surfactant administration decreases BPD and mortality. Therefore, there is rationale for hypothesizing a reduction in BPD or death in the group of patients in which the decision to administer exogenous surfactant is based on lung ultrasound scores. ClinicalTrials.gov identifier NCT05198375 . Registered on 20 January 2022.
Sections du résumé
BACKGROUND
BACKGROUND
The management of respiratory distress syndrome (RDS) in premature newborns is based on different types of non-invasive respiratory support and on surfactant replacement therapy (SRT) to avoid mechanical ventilation as it may eventually result in lung damage. European guidelines currently recommend SRT only when the fraction of inspired oxygen (FiO
METHODS/DESIGN
METHODS
In this study, 668 spontaneously-breathing preterm infants, born at 25
DISCUSSION
CONCLUSIONS
Based on previous published studies, it seems that LUS may decrease the time to administer surfactant therapy. It is known that early surfactant administration decreases BPD and mortality. Therefore, there is rationale for hypothesizing a reduction in BPD or death in the group of patients in which the decision to administer exogenous surfactant is based on lung ultrasound scores.
TRIAL REGISTRATION
BACKGROUND
ClinicalTrials.gov identifier NCT05198375 . Registered on 20 January 2022.
Identifiants
pubmed: 37925512
doi: 10.1186/s13063-023-07745-8
pii: 10.1186/s13063-023-07745-8
pmc: PMC10625281
doi:
Substances chimiques
Oxygen
S88TT14065
Pulmonary Surfactants
0
Surface-Active Agents
0
Banques de données
ClinicalTrials.gov
['NCT05198375']
Types de publication
Randomized Controlled Trial
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
706Informations de copyright
© 2023. The Author(s).
Références
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