Perinatal asphyxia and hypothermic treatment from the endocrine perspective.
electrolytes disturbances
endocrine sequelae
glucose abnormalities
hypothermic treatment
perinatal asphyxia
stress adaptations
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
29
06
2023
accepted:
06
10
2023
medline:
7
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
epublish
Résumé
Perinatal asphyxia is one of the three most important causes of neonatal mortality and morbidity. Therapeutic hypothermia represents the standard treatment for infants with moderate-severe perinatal asphyxia, resulting in reduction in the mortality and major neurodevelopmental disability. So far, data in the literature focusing on the endocrine aspects of both asphyxia and hypothermia treatment at birth are scanty, and many aspects are still debated. Aim of this narrative review is to summarize the current knowledge regarding the short- and long-term effects of perinatal asphyxia and of hypothermia treatment on the endocrine system, thus providing suggestions for improving the management of asphyxiated children. Involvement of the endocrine system (especially glucose and electrolyte disturbances, adrenal hemorrhage, non-thyroidal illness syndrome) can occur in a variable percentage of subjects with perinatal asphyxia, potentially affecting mortality as well as neurological outcome. Hypothermia may also affect endocrine homeostasis, leading to a decreased incidence of hypocalcemia and an increased risk of dilutional hyponatremia and hypercalcemia. Metabolic abnormalities in the context of perinatal asphyxia are important modifiable factors that may be associated with a worse outcome. Therefore, clinicians should be aware of the possible occurrence of endocrine complication, in order to establish appropriate screening protocols and allow timely treatment.
Identifiants
pubmed: 37929024
doi: 10.3389/fendo.2023.1249700
pmc: PMC10623321
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1249700Informations de copyright
Copyright © 2023 Improda, Capalbo, Poloniato, Garbetta, Dituri, Penta, Aversa, Sessa, Vierucci, Cozzolino, Vigone, Tronconi, del Pistoia, Lucaccioni, Tuli, Munarin, Tessaris, de Sanctis and Salerno.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Clin Perinatol. 2016 Sep;43(3):409-22
pubmed: 27524444
Diagn Interv Radiol. 2015 May-Jun;21(3):262-6
pubmed: 25858521
Int J Mol Sci. 2021 Jul 26;22(15):
pubmed: 34360746
Arch Endocrinol Metab. 2022 Sept 08;66(4):466-471
pubmed: 35657132
Biomedicines. 2022 Feb 01;10(2):
pubmed: 35203556
Acta Paediatr. 1999 Jan;88(1):76-81
pubmed: 10090553
J Pediatr Endocrinol Metab. 2007 Mar;20(3):441-4
pubmed: 17451084
AJNR Am J Neuroradiol. 1991 Jan-Feb;12(1):161-4
pubmed: 1899503
Clin Exp Nephrol. 2015 Dec;19(6):1142-8
pubmed: 25715867
Brain. 2013 Jan;136(Pt 1):90-105
pubmed: 23183236
Eur J Pediatr. 2009 Jul;168(7):833-8
pubmed: 18843505
Pediatr Radiol. 1992;22(7):477-80
pubmed: 1491901
Front Synaptic Neurosci. 2020 Sep 23;12:35
pubmed: 33071771
Pediatr Int. 2000 Oct;42(5):514-6
pubmed: 11059541
Dev Med Child Neurol. 1999 Jun;41(6):392-5
pubmed: 10400173
Cochrane Database Syst Rev. 2013 Jan 31;(1):CD003311
pubmed: 23440789
Neural Regen Res. 2012 Oct 5;7(28):2221-6
pubmed: 25538743
Pediatrics. 2002 Nov;110(5):897-902
pubmed: 12415027
Ther Hypothermia Temp Manag. 2023 Mar;13(1):11-15
pubmed: 35696232
Diagnostics (Basel). 2022 Mar 06;12(3):
pubmed: 35328199
Ther Hypothermia Temp Manag. 2018 May 7;:
pubmed: 29733266
Curr Neurovasc Res. 2010 Aug;7(3):223-37
pubmed: 20560877
Indian J Pediatr. 2010 Mar;77(3):259-62
pubmed: 20177828
Curr Urol Rep. 2009 Jan;10(1):78-83
pubmed: 19116100
Pediatr Res. 2020 Aug;88(2):218-224
pubmed: 32120381
Front Pediatr. 2022 Oct 31;10:999274
pubmed: 36389353
Indian J Pediatr. 2014 Mar;81(3):231-3
pubmed: 24519357
J Clin Invest. 2008 Mar;118(3):975-83
pubmed: 18259611
Int J Mol Sci. 2016 Dec 22;18(1):
pubmed: 28025500
Brain Pathol. 1992 Jul;2(3):229-34
pubmed: 1343838
Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E429-39
pubmed: 26173460
Semin Fetal Neonatal Med. 2021 Aug;26(4):101269
pubmed: 34340905
Pediatr Clin North Am. 2019 Feb;66(1):209-226
pubmed: 30454744
J Pineal Res. 2023 Aug;75(1):e12885
pubmed: 37183291
Int J Endocrinol. 2017;2017:4807163
pubmed: 28791047
Pediatr Radiol. 2013 Dec;43(12):1577-83
pubmed: 23852563
Clin Perinatol. 2018 Mar;45(1):19-30
pubmed: 29406004
Arch Dis Child. 1977 Mar;52(3):197-208
pubmed: 848998
Endocr J. 2005 Feb;52(1):37-43
pubmed: 15758556
Pediatr Neurol. 1990 Mar-Apr;6(2):102-8
pubmed: 2340026
Ital J Pediatr. 2019 May 8;45(1):58
pubmed: 31068206
N Engl J Med. 2005 Oct 13;353(15):1574-84
pubmed: 16221780
Antioxid Redox Signal. 2017 Apr 1;26(10):501-518
pubmed: 27225690
Acta Neurol Belg. 2020 Apr;120(2):277-288
pubmed: 32112349
Horm Res. 2006;65(6):289-94
pubmed: 16612105
J Pediatr. 1985 Oct;107(4):599-602
pubmed: 3930681
Indian J Pediatr. 2011 Jan;78(1):49-54
pubmed: 20927607
Acta Paediatr Scand Suppl. 1990;370:115-20; discussion 121
pubmed: 2260449
Endocrinol Jpn. 1977 Apr;24(2):139-47
pubmed: 872819
Medicine (Baltimore). 2001 Jan;80(1):45-53
pubmed: 11204502
Neuroimage Clin. 2021;32:102835
pubmed: 34601311
J Matern Fetal Neonatal Med. 2019 Nov;32(21):3685-3692
pubmed: 29681183
Semin Perinatol. 2010 Dec;34(6):371-86
pubmed: 21094412
Neuroreport. 2006 Jan 23;17(1):55-9
pubmed: 16361950
Thyroid. 2021 Mar;31(3):387-419
pubmed: 33272083
J Endocrinol Invest. 2021 Aug;44(8):1597-1607
pubmed: 33320308
J Clin Invest. 2021 Jan 4;131(1):
pubmed: 33393497
J Matern Fetal Neonatal Med. 2012 Oct;25(10):2115-21
pubmed: 22524246
Handb Clin Neurol. 2021;179:249-258
pubmed: 34225966
J Pediatr. 2012 Jul;161(1):88-93
pubmed: 22306045
Arch Dis Child Fetal Neonatal Ed. 2016 Mar;101(2):F149-55
pubmed: 26283669
J Chem Neuroanat. 2011 Jul;41(4):182-99
pubmed: 21640183
Semin Fetal Neonatal Med. 2021 Aug;26(4):101268
pubmed: 34301501
Indian J Pediatr. 1991 Sep-Oct;58 Suppl 1:33-42
pubmed: 1824373
J Clin Med. 2016 Jan 26;5(2):
pubmed: 26821051
J Pediatr. 1980 Mar;96(3 Pt 1):397-402
pubmed: 7359232
Eur J Pediatr. 2023 Feb;182(2):837-844
pubmed: 36484862
Oncotarget. 2016 Mar 15;7(11):11972-83
pubmed: 26943046
Pediatr Neurol. 2002 May;26(5):379-82
pubmed: 12057799
Neonatology. 2023;120(3):325-333
pubmed: 37321183
Lancet. 2021 Feb 13;397(10274):613-629
pubmed: 33484633
Ital J Pediatr. 2018 May 21;44(1):56
pubmed: 29784025
Ann Pharmacother. 2007 Sep;41(9):1456-65
pubmed: 17698896
Early Hum Dev. 2015 Sep;91(9):535-40
pubmed: 26172341
J Pediatr. 2022 Jun;245:30-38.e1
pubmed: 35120986
J Pediatr. 2019 Aug;211:13-19.e3
pubmed: 31155392
World J Pediatr. 2011 Nov;7(4):355-7
pubmed: 21874621
Eur J Pediatr. 1996 Mar;155(3):245-8
pubmed: 8929736
J Clin Endocrinol Metab. 2005 Aug;90(8):4579-86
pubmed: 15886236
Indian J Clin Biochem. 2000 Aug;15(1):36-9
pubmed: 23105235
Lancet. 2005 Feb 19-25;365(9460):663-70
pubmed: 15721471
Eur J Paediatr Neurol. 2015 Mar;19(2):122-33
pubmed: 25553845
Acta Neuropathol. 1998 Dec;96(6):610-20
pubmed: 9845291
JAMA Pediatr. 2015 Apr;169(4):397-403
pubmed: 25685948
BMC Pediatr. 2022 May 5;22(1):248
pubmed: 35513814
Clin Perinatol. 2009 Dec;36(4):859-80, vii
pubmed: 19944839
EClinicalMedicine. 2023 Mar 23;58:101914
pubmed: 37181414
Adv Clin Exp Med. 2020 Aug;29(8):1011-1016
pubmed: 32820870
J Pineal Res. 2002 Nov;33(4):218-24
pubmed: 12390504
Arch Dis Child. 2020 Apr;105(4):399-405
pubmed: 31900251
Pediatr Neurol. 2014 Jun;50(6):586-90
pubmed: 24731484
J Reprod Fertil. 1997 May;110(1):145-51
pubmed: 9227368
Acta Paediatr. 2003;92(3):339-45
pubmed: 12725550
Int J Mol Sci. 2022 Aug 05;23(15):
pubmed: 35955859
Childs Nerv Syst. 2003 Nov;19(10-11):750-5
pubmed: 12920545
J Matern Fetal Neonatal Med. 2015;28(17):2062-5
pubmed: 25327176
AJNR Am J Neuroradiol. 2013 Jul;34(7):1456-61
pubmed: 23436054
Free Radic Biol Med. 2019 Oct;142:113-122
pubmed: 31039399
Semin Fetal Neonatal Med. 2021 Aug;26(4):101261
pubmed: 34140246
Seizure. 2015 May;28:12-7
pubmed: 25797888
N Engl J Med. 2015 Oct 15;373(16):1507-18
pubmed: 26465984
Neuro Endocrinol Lett. 2011;32(5):663-6
pubmed: 22167146
Folia Neuropathol. 2003;41(4):209-15
pubmed: 14977250
Drug Metab Dispos. 2016 Mar;44(3):445-52
pubmed: 26884482
Pediatrics. 2012 Jun;129(6):e1461-7
pubmed: 22614771
Clin Perinatol. 2018 Mar;45(1):41-59
pubmed: 29406006
J Matern Fetal Neonatal Med. 2012 Feb;25(2):141-6
pubmed: 21627548
Arch Dis Child Fetal Neonatal Ed. 2000 May;82(3):F250-4
pubmed: 10794797
Am J Perinatol. 2020 Sep;37(S 02):S57-S60
pubmed: 32898884
Mol Cell Pediatr. 2022 Nov 24;9(1):18
pubmed: 36427118
Pediatr Int. 2018 May;60(5):433-437
pubmed: 29460458
Acta Paediatr. 2013 Nov;102(11):e507-13
pubmed: 23879198
Stroke. 2009 Feb;40(2):610-7
pubmed: 19023096
Cochrane Database Syst Rev. 2005 Jul 20;(3):CD004337
pubmed: 16034927
Lancet Diabetes Endocrinol. 2016 Mar;4(3):265-274
pubmed: 26852255
Pediatr Res. 2004 Oct;56(4):621-9
pubmed: 15319457
J Clin Res Pediatr Endocrinol. 2017 Dec 30;9(Suppl 2):69-87
pubmed: 29280746
J Physiol. 1995 Sep 1;487 ( Pt 2):513-25
pubmed: 8558480
Early Hum Dev. 2010 Jun;86(6):345-50
pubmed: 20605382
J Matern Fetal Neonatal Med. 2019 Aug;32(16):2727-2734
pubmed: 29504433
Best Pract Res Clin Endocrinol Metab. 2016 Dec;30(6):785-794
pubmed: 27974191
J Matern Fetal Neonatal Med. 2020 Oct;33(20):3521-3528
pubmed: 30714445
Horm Res. 1991;35(3-4):104-8
pubmed: 1806462
Med Ultrason. 2022 Aug 31;24(3):284-289
pubmed: 35437529
J Perinatol. 2018 Nov;38(11):1512-1517
pubmed: 30206346
AJR Am J Roentgenol. 2001 Aug;177(2):357-8
pubmed: 11461861
Inflamm Res. 2013 Jan;62(1):81-7
pubmed: 22986466
Diabetes Obes Metab. 2007 Nov;9 Suppl 2:140-6
pubmed: 17919188
Pediatr Neonatol. 2017 Dec;58(6):504-508
pubmed: 28462900
Neuroendocrinology. 2020;110(3-4):161-171
pubmed: 31401632
Front Pediatr. 2016 Aug 02;4:75
pubmed: 27532032
Turk J Pediatr. 2011 Jan-Feb;53(1):43-7
pubmed: 21534338
J Pediatr. 2018 Sep;200:6-8
pubmed: 29753545
Front Pediatr. 2019 Nov 14;7:462
pubmed: 31799222
Pediatrics. 2006 Oct;118(4):1456-66
pubmed: 17015536
Eur J Pediatr. 2012 Oct;171(10):1511-7
pubmed: 22669637
Best Pract Res Clin Endocrinol Metab. 2019 Jun;33(3):101262
pubmed: 30733078
J Pediatr. 2015 Aug;167(2):238-45
pubmed: 25957977
Pediatr Crit Care Med. 2020 Jul;21(7):647-655
pubmed: 32168305
Int J Mol Sci. 2023 Jan 20;24(3):
pubmed: 36768443
J Paediatr Child Health. 2017 Mar;53(3):295-300
pubmed: 27701803
J Clin Endocrinol Metab. 1999 Jan;84(1):151-64
pubmed: 9920076
Eur J Pediatr. 1992 Apr;151(4):263-5
pubmed: 1499577
Endocr J. 2022 Aug 29;69(8):927-939
pubmed: 35236792
Tohoku J Exp Med. 1990 Mar;160(3):189-202
pubmed: 2112793
J Pediatr Endocrinol. 1994 Jan-Mar;7(1):39-41
pubmed: 8186822
Eur J Obstet Gynecol Reprod Biol. 2000 Nov;93(1):53-5
pubmed: 11000504
J Diabetes Metab Disord. 2015 Dec 01;14:87
pubmed: 26629481
J Pediatr. 2019 Jun;209:23-32
pubmed: 30982528
J Endocrinol. 2010 Apr;205(1):1-13
pubmed: 20016054