Self-reported sleep fragmentation and sleep duration and their association with cognitive function in PROTECT, a large digital community-based cohort of people over 50.
cognitive function
older adults
sleep duration
sleep fragmentation
Journal
International journal of geriatric psychiatry
ISSN: 1099-1166
Titre abrégé: Int J Geriatr Psychiatry
Pays: England
ID NLM: 8710629
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
16
06
2023
accepted:
17
10
2023
medline:
7
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
ppublish
Résumé
Sleep is vital for normal cognitive function in daily life, but is commonly disrupted in older adults. Poor sleep can be detrimental to mental and physical health, including cognitive function. This study assessed the association between self-reported short (<6 h) and long (>9 h) sleep duration and sleep fragmentation (3≥ nightly awakenings) in cognitive function. Cross-sectional data from 8508 individuals enroled in the PROTECT study aged 50 and above formed the basis of the univariate linear regression analysis conducted on four cognitive outcomes assessing visuospatial episodic memory (VSEM), spatial working memory, verbal working memory (VWM), and verbal reasoning (VR). Short (ß = -0.153, 95% CI [-0.258, -0.048], p = 0.004) and long sleep duration (ß = -0.459, 95% CI [-0.826, -0.091], p = 0.014) were significantly associated with poorer cognitive performance in VWM. Long sleep duration (ß = -2.986, 95% CI [-5.453, -0.518], p = 0.018) was associated with impaired VR. Short sleep (ß = -0.133, 95% CI [-0.196, -0.069], p = <0.001) and sleep fragmentation (ß = -0.043, 95% CI [-0.085, -0.001], p = 0.043) were associated with reduced VSEM. These associations remained significant when including other established risk factors for dementia and cognitive decline (e.g., depression, hypertension). Our findings suggest that short and long sleep durations and fragmented sleep, may be risk factors for a decline in cognitive processes such as working memory, VR and episodic memory thus might be potential targets for interventions to maintain cognitive health in ageing.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e6022Subventions
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© 2023 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.
Références
Miner B, Kryger MH. Sleep in the aging population. Sleep Med Clin. 2017;12(1):31-38. https://doi.org/10.1016/j.jsmc.2016.10.008
Vaz Fragoso CA, Gill TM. Sleep complaints in community-living older persons: a multifactorial geriatric syndrome. J Am Geriatr Soc. 2007;55(11):1853-1866. https://doi.org/10.1111/j.1532-5415.2007.01399.x
Yin J, Jin X, Shan Z, et al. Relationship of sleep duration with all-cause mortality and cardiovascular events: a systematic review and dose-response meta-analysis of prospective cohort studies. J Am Heart Assoc. 2017;6(9). https://doi.org/10.1161/jaha.117.005947
Laksono S, Yanni M, Iqbal M, Prawara AS. Abnormal sleep duration as predictor for cardiovascular diseases: a systematic review of prospective studies. Sleep Disord. 2022;2022:9969107-9969110. https://doi.org/10.1155/2022/9969107
Fang H, Tu S, Sheng J, Shao A. Depression in sleep disturbance: a review on a bidirectional relationship, mechanisms and treatment. J Cell Mol Med. 2019;23(4):2324-2332. https://doi.org/10.1111/jcmm.14170
Alhola P, Polo-Kantola P. Sleep deprivation: impact on cognitive performance. Neuropsychiatric Dis Treat. 2007;3(5):553-567.
Yaffe K, Falvey CM, Hoang T. Connections between sleep and cognition in older adults. Lancet Neurol. 2014;13(10):1017-1028. https://doi.org/10.1016/s1474-4422(14)70172-3
Lo JC, Groeger JA, Cheng GH, Dijk DJ, Chee MW. Self-reported sleep duration and cognitive performance in older adults: a systematic review and meta-analysis. Sleep Med. 2016;17:87-98. https://doi.org/10.1016/j.sleep.2015.08.021
Liang Y, Qu LB, Liu H. Non-linear associations between sleep duration and the risks of mild cognitive impairment/dementia and cognitive decline: a dose-response meta-analysis of observational studies. Aging Clin Exp Res. 2019;31(3):309-320. https://doi.org/10.1007/s40520-018-1005-y
Wu L, Sun D, Tan Y. A systematic review and dose-response meta-analysis of sleep duration and the occurrence of cognitive disorders. Sleep Breath. 2018;22(3):805-814. https://doi.org/10.1007/s11325-017-1527-0
Blackwell T, Yaffe K, Ancoli-Israel S, et al. Association of sleep characteristics and cognition in older community-dwelling men: the MrOS sleep study. Sleep. 2011;34(10):1347-1356. https://doi.org/10.5665/sleep.1276
Fine L, Weinborn M, Ng A, et al. Sleep disruption explains age-related prospective memory deficits: implications for cognitive aging and intervention. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2019;26(4):621-636. https://doi.org/10.1080/13825585.2018.1513449
Oosterman JM, van Someren EJ, Vogels RL, Van Harten B, Scherder EJ. Fragmentation of the rest-activity rhythm correlates with age-related cognitive deficits. J Sleep Res. 2009;18(1):129-135. https://doi.org/10.1111/j.1365-2869.2008.00704.x
Spira AP, Stone KL, Redline S, et al. Actigraphic sleep duration and fragmentation in older women: associations with performance across cognitive domains. Sleep. 2017;40(8). https://doi.org/10.1093/sleep/zsx073
Lim AS, Kowgier M, Yu L, Buchman AS, Bennett DA. Sleep fragmentation and the risk of incident Alzheimer's disease and cognitive decline in older persons. Sleep. 2013;36(7):1027-1032. https://doi.org/10.5665/sleep.2802
Bubu OM, Andrade AG, Umasabor-Bubu OQ, et al. Obstructive sleep apnea, cognition and Alzheimer's disease: a systematic review integrating three decades of multidisciplinary research. Sleep Med Rev. 2020;50:101250. https://doi.org/10.1016/j.smrv.2019.101250
Bubu OM, Brannick M, Mortimer J, et al. Sleep, cognitive impairment, and Alzheimer's disease: a systematic review and meta-analysis. Sleep. 2017;40(1). https://doi.org/10.1093/sleep/zsw032
de Almondes KM, Costa MV, Malloy-Diniz LF, Diniz BS. Insomnia and risk of dementia in older adults: systematic review and meta-analysis. J Psychiatr Res. 2016;77:109-115. https://doi.org/10.1016/j.jpsychires.2016.02.021
Shi L, Chen SJ, Ma MY, et al. Sleep disturbances increase the risk of dementia: a systematic review and meta-analysis. Sleep Med Rev. 2018;40:4-16. https://doi.org/10.1016/j.smrv.2017.06.010
Wennberg AMV, Wu MN, Rosenberg PB, Spira AP. Sleep disturbance, cognitive decline, and dementia: a review. Semin Neurol. 2017;37(4):395-406. https://doi.org/10.1055/s-0037-1604351
Sabia S, Fayosse A, Dumurgier J, et al. Association of sleep duration in middle and old age with incidence of dementia. Nat Commun. 2021;12(1):2289. https://doi.org/10.1038/s41467-021-22354-2
Selbaek-Tungevåg S, Selbaek G, Strand BH, et al. Insomnia and risk of dementia in a large population-based study with 11-year follow-up: the HUNT study. J Sleep Res. 2023;32(4):e13820. https://doi.org/10.1111/jsr.13820
Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413-446. https://doi.org/10.1016/s0140-6736(20)30367-6
Scullin MK, Bliwise DL. Sleep, cognition, and normal aging: integrating a half century of multidisciplinary research. Perspect Psychol Sci. 2015;10(1):97-137. https://doi.org/10.1177/1745691614556680
Victor C, Scambler S, Bond J, Bowling A. Being alone in later life: loneliness, social isolation and living alone. Rev Clin Gerontology. 2000;10(4):407-417. https://doi.org/10.1017/S0959259800104101
von Soest T, Luhmann M, Hansen T, Gerstorf D. Development of loneliness in midlife and old age: its nature and correlates. J Pers Soc Psychol. 2020;118(2):388-406. https://doi.org/10.1037/pspp0000219
Ellis BW, Johns MW, Lancaster R, Raptopoulos P, Angelopoulos N, Priest RG. The St. Mary's Hospital sleep questionnaire: a study of reliability. Sleep. 1981;4(1):93-97. https://doi.org/10.1093/sleep/4.1.93
Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606-613. https://doi.org/10.1046/j.1525-1497.2001.016009606.x
Kroenke K, Spitzer RL, Williams JB, Löwe B. The patient health questionnaire somatic, anxiety, and depressive symptom scales: a systematic review. Gen Hosp Psychiatr. 2010;32(4):345-359. https://doi.org/10.1016/j.genhosppsych.2010.03.006
Corbett A, Owen A, Hampshire A, et al. The effect of an online cognitive training package in healthy older adults: an online randomized controlled trial. J Am Med Dir Assoc. 2015;16(11):990-997. https://doi.org/10.1016/j.jamda.2015.06.014
Huntley J, Corbett A, Wesnes K, et al. Online assessment of risk factors for dementia and cognitive function in healthy adults. Int J Geriatr Psychiatr. 2018;33(2):e286-e293. https://doi.org/10.1002/gps.4790
Johar H, Kawan R, Emeny RT, Ladwig KH. Impaired sleep predicts cognitive decline in old people: findings from the prospective KORA age study. Sleep. 2016;39(1):217-226. https://doi.org/10.5665/sleep.5352
Brachem C, Winkler A, Tebrügge S, et al. Associations between self-reported sleep characteristics and incident mild cognitive impairment: the Heinz Nixdorf Recall Cohort Study. Sci Rep. 2020;10(1):6542. https://doi.org/10.1038/s41598-020-63511-9
Hartescu I, Morgan K, Stevinson CD. Increased physical activity improves sleep and mood outcomes in inactive people with insomnia: a randomized controlled trial. J Sleep Res. 2015;24(5):526-534. https://doi.org/10.1111/jsr.12297
Pearce M, Garcia L, Abbas A, et al. Association between physical activity and risk of depression: a systematic review and meta-analysis. JAMA Psychiatr. 2022;79(6):550-559. https://doi.org/10.1001/jamapsychiatry.2022.0609
Stern Y, Arenaza-Urquijo EM, Bartrés-Faz D, et al. Whitepaper: defining and investigating cognitive reserve, brain reserve, and brain maintenance. Alzheimers Dement. 2020;16(9):1305-1311. https://doi.org/10.1016/j.jalz.2018.07.219
Franks KH, Rowsthorn E, Nicolazzo J, et al. The treatment of sleep dysfunction to improve cognitive function: a meta-analysis of randomized controlled trials. Sleep Med. 2023;101:118-126. https://doi.org/10.1016/j.sleep.2022.10.021
Li J, McPhillips MV, Deng Z, Fan F, Spira A. Daytime napping and cognitive health in older adults: a systematic review. J Gerontol A Biol Sci Med Sci. 2023;78(10):1853-1860. https://doi.org/10.1093/gerona/glac239