Enhancing the antibacterial function of probiotic
Escherichia coli Nissle
microcin C
probiotics
promoters
Journal
Applied and environmental microbiology
ISSN: 1098-5336
Titre abrégé: Appl Environ Microbiol
Pays: United States
ID NLM: 7605801
Informations de publication
Date de publication:
29 Nov 2023
29 Nov 2023
Historique:
medline:
30
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
ppublish
Résumé
Probiotic bacteria confer multiple health benefits, including preventing the growth, colonization, or carriage of harmful bacteria in the gut. Bacteriocins are antibacterial peptides produced by diverse bacteria, and their production is tightly regulated and coordinated at the transcriptional level. A popular strategy for enhancing the antibacterial properties of probiotic bacteria is to retrofit them with the ability to overproduce heterologous bacteriocins. This is often achieved from non-native constitutive promoters or in response to host or pathogen signal from synthetic promoters. How the dysregulated overproduction of heterologous bacteriocins affects the fitness and antibacterial efficacy of the retrofitted probiotic bacteria is often overlooked. We have conferred the prototypical probiotic
Identifiants
pubmed: 37930328
doi: 10.1128/aem.00975-23
pmc: PMC10686094
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacteriocins
0
Escherichia coli Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0097523Subventions
Organisme : UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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