Mapping the neuroanatomical abnormalities in a phenotype of male compulsive rats.
Compulsive behavior
Cortico-striatal-thalamic-cortical circuit
Magnetic resonance imaging
Schedule-Induced Polydipsia
Voxel-based morphometry
White matter
Journal
Behavioral and brain functions : BBF
ISSN: 1744-9081
Titre abrégé: Behav Brain Funct
Pays: England
ID NLM: 101245751
Informations de publication
Date de publication:
06 Nov 2023
06 Nov 2023
Historique:
received:
10
11
2022
accepted:
28
10
2023
medline:
8
11
2023
pubmed:
7
11
2023
entrez:
7
11
2023
Statut:
epublish
Résumé
Compulsivity is considered a transdiagnostic dimension in obsessive-compulsive and related disorders, characterized by heterogeneous cognitive and behavioral phenotypes associated with abnormalities in cortico-striatal-thalamic-cortical circuitry. The present study investigated the structural morphology of white and gray matter in rats selected for low- (LD) and high- (HD) compulsive drinking behavior on a schedule-induced polydipsia (SIP) task. Regional brain morphology was assessed using ex-vivo high-resolution magnetic resonance imaging (MRI). Voxel-based morphometry of segmented MRI images revealed larger white matter volumes in anterior commissure and corpus callosum of HD rats compared with LD rats. HD rats also showed significantly larger regional volumes of dorsolateral orbitofrontal cortex, striatum, amygdala, hippocampus, midbrain, sub-thalamic nucleus, and cerebellum. By contrast, the medial prefrontal cortex was significantly smaller in HD rats compared with LD rats with no significant group differences in whole brain, ventricular, or cerebrospinal fluid volumes. These findings show that limbic cortico-basal ganglia structures implicated in impulse control disorders are distinct in rats that are vulnerable to develop compulsive behavior. Such abnormalities may be relevant to the etiology of compulsive disorders in humans.
Identifiants
pubmed: 37932782
doi: 10.1186/s12993-023-00221-y
pii: 10.1186/s12993-023-00221-y
pmc: PMC10626819
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19Subventions
Organisme : FEDER I+D+I "una manera de hacer Europa"
ID : UAL2020-CTSD2068
Organisme : Plan Nacional sobre Drogas
ID : PND-2022l024
Organisme : Ministerio de Ciencia e Innovación
ID : PID2022-139286NB-I00
Informations de copyright
© 2023. The Author(s).
Références
Addict Biol. 2019 Jul;24(4):787-801
pubmed: 29847018
Psychiatry Res. 2019 Jan;271:259-264
pubmed: 30508669
Int Clin Psychopharmacol. 2020 Jul;35(4):173-193
pubmed: 32433254
Proc Natl Acad Sci U S A. 2010 May 4;107(18):8452-6
pubmed: 20404184
Psychiatry Res. 2013 Jul 30;213(1):11-7
pubmed: 23701704
Nat Commun. 2019 Dec 13;10(1):5699
pubmed: 31836716
Arch Gen Psychiatry. 2004 Jul;61(7):720-30
pubmed: 15237084
Psychopharmacology (Berl). 2019 Oct;236(10):2937-2958
pubmed: 30737597
Psychiatry Res Neuroimaging. 2021 Jul 30;313:111301
pubmed: 34022542
Neuropsychopharmacology. 2014 Jun;39(7):1547-57
pubmed: 24407265
Nature. 2004 Jan 22;427(6972):311-2
pubmed: 14737157
Nat Rev Neurosci. 2020 May;21(5):247-263
pubmed: 32231315
Biol Psychiatry. 2005 Aug 1;58(3):226-32
pubmed: 15939406
Am J Psychiatry. 2016 Sep 9;174(1):60-69
pubmed: 27609241
Behav Brain Res. 2016 Oct 15;313:17-22
pubmed: 27388149
Arch Gen Psychiatry. 2005 Mar;62(3):301-9
pubmed: 15753243
Neuron. 2015 Oct 21;88(2):345-56
pubmed: 26494279
Annu Rev Psychol. 2016;67:23-50
pubmed: 26253543
Front Behav Neurosci. 2019 May 07;13:99
pubmed: 31133834
Neurosci Biobehav Rev. 2009 Jun;33(6):831-42
pubmed: 19428495
Curr Med Imaging Rev. 2019;15(9):895-899
pubmed: 32008536
Eur Psychiatry. 2019 Oct;62:38-44
pubmed: 31525581
J Neurosurg. 2004 Jun;100(6):1084-6
pubmed: 15200126
Exp Neurol. 2009 Jan;215(1):101-9
pubmed: 18951894
J Comp Physiol Psychol. 1978 Aug;92(4):651-60
pubmed: 690288
Schizophr Bull. 2017 Jul 1;43(4):778-787
pubmed: 27872269
Brain Imaging Behav. 2020 Dec;14(6):2084-2096
pubmed: 31342238
Nat Neurosci. 2012 Jun;15(6):920-5
pubmed: 22544311
Physiol Behav. 2022 Mar 1;245:113670
pubmed: 34890592
J Neurochem. 2021 Oct;159(1):128-144
pubmed: 34081798
J Neurol Neurosurg Psychiatry. 2011 Dec;82(12):1304-13
pubmed: 21693631
Neuropsychopharmacology. 2004 Apr;29(4):826-32
pubmed: 14970831
Brain Stimul. 2019 Jul - Aug;12(4):922-929
pubmed: 30808612
Behav Brain Funct. 2021 May 18;17(1):4
pubmed: 34006308
Psychiatry Res. 2004 Nov 15;132(1):69-79
pubmed: 15546704
Neuropsychopharmacology. 2015 Mar 13;40(5):1192-202
pubmed: 25425323
Psychol Med. 2014 May;44(7):1461-73
pubmed: 24001313
Brain Res. 2018 Apr 15;1685:1-8
pubmed: 29427578
Magn Reson Med Sci. 2015;14(4):329-35
pubmed: 26104070
Dialogues Clin Neurosci. 2016 Mar;18(1):7-21
pubmed: 27069376
Dev Neuropsychol. 2010;35(3):278-95
pubmed: 20446133
Exp Neurol. 2008 Mar;210(1):217-28
pubmed: 18076877
Psychiatry Res Neuroimaging. 2019 Feb 28;284:45-52
pubmed: 30684895
Philos Trans R Soc Lond B Biol Sci. 2012 Aug 5;367(1599):2097-107
pubmed: 22734053
Eur Neuropsychopharmacol. 2013 Jul;23(7):569-80
pubmed: 22841131
Schizophr Res. 2009 Feb;107(2-3):128-33
pubmed: 18984069
Behav Brain Res. 2020 Jul 15;390:112592
pubmed: 32417273
J Neurosci Methods. 1980 Dec;3(2):129-49
pubmed: 6110810
Behav Brain Res. 1988 Jun;28(3):315-24
pubmed: 2840091
Biol Psychiatry. 2013 Feb 15;73(4):321-8
pubmed: 23200527
Biol Psychiatry. 2014 Apr 15;75(8):647-52
pubmed: 23938318
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Nov;2(8):655-663
pubmed: 29167834
Sci Rep. 2021 Aug 5;11(1):15980
pubmed: 34354139
Psychopharmacology (Berl). 2015 Dec;232(24):4455-67
pubmed: 26482898
Front Neuroanat. 2020 Oct 23;14:578900
pubmed: 33192342
Brain Res. 2021 Aug 15;1765:147495
pubmed: 33894224
eNeuro. 2017 Aug 7;4(4):
pubmed: 28791332
Sci Rep. 2017 Jul 18;7(1):5744
pubmed: 28720860
Transl Psychiatry. 2020 Aug 12;10(1):280
pubmed: 32788572
Depress Anxiety. 2018 Aug;35(8):742-751
pubmed: 29734487
J Affect Disord. 2018 Aug 15;236:1-5
pubmed: 29704655
Biol Psychiatry. 2014 Apr 15;75(8):595-605
pubmed: 24314349
J Neurochem. 2021 Oct;159(1):12-14
pubmed: 34252196
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1283-6
pubmed: 18485556
Psychiatry Res Neuroimaging. 2019 Mar 30;285:40-46
pubmed: 30731370
Nat Commun. 2019 Aug 1;10(1):3455
pubmed: 31371763
J Obsessive Compuls Relat Disord. 2020 Jul;26:
pubmed: 34650904
Mol Psychiatry. 2016 Apr;21(4):491-9
pubmed: 26370145
Schizophr Res. 2002 Oct 1;57(2-3):293-301
pubmed: 12223261
Arch Gen Psychiatry. 2009 Nov;66(11):1189-200
pubmed: 19884607
Neuron. 2013 Oct 30;80(3):807-15
pubmed: 24183029
Neurosurgery. 2020 Nov 16;87(6):1098-1110
pubmed: 32615588
JAMA Psychiatry. 2013 Jun;70(6):608-18; quiz 554
pubmed: 23740049
Psychopharmacology (Berl). 2014 May;231(9):2001-8
pubmed: 24241687
Expert Rev Med Devices. 2015 Jul;12(4):381-91
pubmed: 25982412
Eur Neuropsychopharmacol. 2016 May;26(5):856-68
pubmed: 26774279
Prog Neuropsychopharmacol Biol Psychiatry. 2015 Aug 3;61:37-43
pubmed: 25816789
Emerg Top Life Sci. 2022 Dec 9;6(5):491-500
pubmed: 36377776
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Dec 20;87(Pt A):11-21
pubmed: 28887182
Hum Brain Mapp. 2017 Mar;38(3):1182-1190
pubmed: 27787929
Curr Protoc Neurosci. 2008 Apr;Chapter 9:Unit 9.27
pubmed: 18428677
Lancet. 2002 Oct 26;360(9342):1302-4
pubmed: 12414208
Front Syst Neurosci. 2019 Jul 18;13:28
pubmed: 31379523
Cell. 2015 Aug 13;162(4):712-25
pubmed: 26276628
J Affect Disord. 2008 Jul;109(1-2):117-26
pubmed: 18342953
Neurobiol Dis. 2009 Jan;33(1):20-7
pubmed: 18930824
Curr Neuropharmacol. 2023;21(9):1924-1933
pubmed: 36411566
Psychiatry Investig. 2020 Aug;17(8):777-785
pubmed: 32777920
Neuroscience. 2015 Aug 6;300:238-45
pubmed: 25988756
Physiol Behav. 1988;43(3):269-73
pubmed: 3174839
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3216-3221
pubmed: 28265059
Genes Brain Behav. 2019 Mar;18(3):e12489
pubmed: 29877027
IEEE Trans Med Imaging. 2010 Jun;29(6):1310-20
pubmed: 20378467
J Am Acad Child Adolesc Psychiatry. 2018 Jan;57(1):41-47
pubmed: 29301668
Biol Psychiatry. 1994 Mar 15;35(6):408-19
pubmed: 8018788
J Exp Anal Behav. 1966 Jan;9(1):37-9
pubmed: 5903958
Arch Gen Psychiatry. 1999 Oct;56(10):913-9
pubmed: 10530633
Neuropsychopharmacology. 2016 Apr;41(5):1395-403
pubmed: 26440813
Eur Neuropsychopharmacol. 2020 Apr;33:58-70
pubmed: 32151497
J Pers Med. 2020 Dec 12;10(4):
pubmed: 33322765
Neuroscientist. 2012 Aug;18(4):320-5
pubmed: 22013150
Brain Imaging Behav. 2021 Jun;15(3):1388-1402
pubmed: 32700253
PLoS One. 2013 Nov 14;8(11):e80151
pubmed: 24244633
Exp Neurol. 2019 Jul;317:87-99
pubmed: 30822421
Ann Neurol. 2004 Apr;55(4):530-40
pubmed: 15048892
Zhonghua Yi Xue Za Zhi. 2012 Dec 4;92(45):3221-3
pubmed: 23328472
Epilepsy Behav. 2016 Dec;65:42-48
pubmed: 27866083
Neuron. 2019 Apr 3;102(1):27-47
pubmed: 30946823
Sci Rep. 2021 Apr 27;11(1):9068
pubmed: 33907199
Arch Gen Psychiatry. 2007 Aug;64(8):946-55
pubmed: 17679639
Epidemiol Psychiatr Sci. 2014 Sep;23(3):235-8
pubmed: 24816251
Psychiatry Res Neuroimaging. 2021 Jan 30;307:111200
pubmed: 33059948
Neurology. 2002 Jul 23;59(2):184-92
pubmed: 12136055
Nat Neurosci. 2016 Apr 26;19(6):656-664
pubmed: 29162973
Int J Neuropsychopharmacol. 2018 Jan 1;21(1):42-58
pubmed: 29036632
Physiol Behav. 1988;43(3):275-9
pubmed: 3174840
Psychiatry Res. 2013 Dec 30;210(3):679-83
pubmed: 23810384
Eur Arch Psychiatry Clin Neurosci. 2007 Jun;257(4):185-90
pubmed: 17464548
Neuropsychopharmacology. 2017 Aug;42(9):1850-1859
pubmed: 27917870
Neurology. 2001 Jul 24;57(2):245-54
pubmed: 11468308
Neuropsychopharmacology. 2019 Oct;44(11):1975-1984
pubmed: 30986819
Addict Biol. 2018 Jan;23(1):182-195
pubmed: 28231635
Neuroimage Clin. 2019;24:102040
pubmed: 31670068
Biol Psychiatry. 2011 Dec 1;70(11):1083-90
pubmed: 21903200
Science. 1961 Jan 20;133(3447):195-6
pubmed: 13698026
Annu Rev Neurosci. 1986;9:357-81
pubmed: 3085570
Psychopharmacology (Berl). 2012 Jan;219(2):647-59
pubmed: 22113447
Annu Rev Neurosci. 2016 Jul 8;39:257-76
pubmed: 27145911
Neuropharmacology. 2018 Dec;143:10-19
pubmed: 30201211
Clin Psychol Rev. 2013 Dec;33(8):1163-71
pubmed: 24128603
Annu Rev Neurosci. 2009;32:413-34
pubmed: 19555291
World J Biol Psychiatry. 2013 May;14(4):319-31
pubmed: 22746998
Curr Biol. 2011 Dec 20;21(24):2109-14
pubmed: 22169537
Nutrients. 2019 Jun 06;11(6):
pubmed: 31174338
Neurosurgery. 2021 Mar 15;88(4):710-712
pubmed: 33559678
World Neurosurg. 2013 Sep-Oct;80(3-4):S31.e1-8
pubmed: 22469523
Psychiatry Res Neuroimaging. 2018 Jun 30;276:65-72
pubmed: 29628272
Neurosci Biobehav Rev. 2017 Jul;78:91-103
pubmed: 28442404