16th International congress on antiphospholipid antibodies task force report on antiphospholipid syndrome laboratory diagnostics and trends.
Phosphatidylserine-dependent antiprothrombin antibodies
anti-β2Glycoprotein-I antibodies
antibodies to domains of β2-glycoprotein-I
Journal
Lupus
ISSN: 1477-0962
Titre abrégé: Lupus
Pays: England
ID NLM: 9204265
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
medline:
24
11
2023
pubmed:
7
11
2023
entrez:
7
11
2023
Statut:
ppublish
Résumé
Classification criteria for antiphospholipid syndrome (APS) require IgG or IgM isotypes of the anticardiolipin (aCL) antibodies, anti-β2 glycoprotein I (anti-β2GPI) antibodies, and/or the lupus anticoagulant (LA) to satisfy the laboratory disease definition. Over the past 20 years, non-criteria antiphospholipid antibodies (aPL) directed to other proteins of the coagulation cascade (i.e. prothrombin and/or phosphatidylserine-prothrombin complex) or to some domains of β2GPI have been proposed. This task force concentrated and reviewed the literature on data including aPS/PT, antibodies to domain 4/5 of β2GPI and the newly described antibodies to protein/HLA-DR complex. In addition, we discussed testing of LA in the 'new' oral anticoagulants' era and the value of triple positivity in the risk assessment of aPL. The conclusions were presented at a special session during the 16
Identifiants
pubmed: 37933818
doi: 10.1177/09612033231211820
pmc: PMC10666497
doi:
Substances chimiques
Prothrombin
9001-26-7
Antibodies, Antiphospholipid
0
Lupus Coagulation Inhibitor
0
Antibodies, Anticardiolipin
0
beta 2-Glycoprotein I
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1625-1636Déclaration de conflit d'intérêts
Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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