The possible place for psychedelics in pharmacotherapy of mental disorders.
5-MeO-DMT
DMT
Fast-acting antidepressant drugs
Ketamine
LSD
Mood disorders
Psilocybin
Journal
Pharmacological reports : PR
ISSN: 2299-5684
Titre abrégé: Pharmacol Rep
Pays: Switzerland
ID NLM: 101234999
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
30
08
2023
accepted:
17
10
2023
revised:
17
10
2023
medline:
22
11
2023
pubmed:
7
11
2023
entrez:
7
11
2023
Statut:
ppublish
Résumé
Since its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting the lives of millions of patients. While crucial in the history of drug development, recent studies undermine the effectiveness of currently used antidepressant drugs in comparison to placebo, emphasizing the long time it takes to initiate the therapeutic response and numerous adverse effects. Thus, the scope of contemporary pharmacological research shifts from drugs affecting the serotonin system to rapid-acting antidepressant drugs. The prototypical representative of the aforementioned class is ketamine, an NMDA receptor antagonist capable of alleviating the symptoms of depression shortly after the drug administration. This discovery led to a paradigm shift, focusing on amino-acidic neurotransmitters and growth factors. Alas, the drug is not perfect, as its therapeutic effect diminishes circa 2 weeks after administration. Furthermore, it is not devoid of some severe side effects. However, there seems to be another, more efficient, and safer way to target the glutamatergic system. Hallucinogenic agonists of the 5-HT
Identifiants
pubmed: 37934320
doi: 10.1007/s43440-023-00550-9
pii: 10.1007/s43440-023-00550-9
pmc: PMC10661751
doi:
Substances chimiques
Hallucinogens
0
Psilocybin
2RV7212BP0
Ketamine
690G0D6V8H
Antidepressive Agents
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1313-1325Informations de copyright
© 2023. The Author(s).
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