The extracellular matrix in tissue morphogenesis: No longer a backseat driver.
Basement membrane
Extracellular matrix
Morphogenesis
Tissue mechanics
Wound healing
Journal
Cells & development
ISSN: 2667-2901
Titre abrégé: Cells Dev
Pays: Netherlands
ID NLM: 101775611
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
received:
20
09
2023
revised:
31
10
2023
accepted:
03
11
2023
medline:
18
3
2024
pubmed:
8
11
2023
entrez:
7
11
2023
Statut:
ppublish
Résumé
The forces driving tissue morphogenesis are thought to originate from cellular activities. While it is appreciated that extracellular matrix (ECM) may also be involved, ECM function is assumed to be simply instructive in modulating the cellular behaviors that drive changes to tissue shape. However, there is increasing evidence that the ECM may not be the passive player portrayed in developmental biology textbooks. In this review we highlight examples of embryonic ECM dynamics that suggest cell-independent activity, along with developmental processes during which localized ECM alterations and ECM-autonomous forces are directing changes to tissue shape. Additionally, we discuss experimental approaches to unveil active ECM roles during tissue morphogenesis. We propose that it may be time to rethink our general definition of morphogenesis as a cellular-driven phenomenon and incorporate an underappreciated, and surprisingly dynamic ECM.
Identifiants
pubmed: 37935283
pii: S2667-2901(23)00059-1
doi: 10.1016/j.cdev.2023.203883
pii:
doi:
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
203883Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.