Can research on entactogens contribute to a deeper understanding of human sexuality?
3,4-methylenedioxymethamphetamine
Entactogens
Psychedelic-assisted psychotherapy
Sexuality
Journal
Pharmacological reports : PR
ISSN: 2299-5684
Titre abrégé: Pharmacol Rep
Pays: Switzerland
ID NLM: 101234999
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
08
09
2023
accepted:
23
10
2023
revised:
22
10
2023
medline:
27
11
2023
pubmed:
8
11
2023
entrez:
7
11
2023
Statut:
ppublish
Résumé
In recent years, scientific research into the therapeutic potential of psychedelic compounds has experienced a resurgence of interest. New studies have shown promising results, supporting the use of psychedelic drugs in treating various psychiatric disorders, including treatment-resistant depression, post-traumatic stress disorder, and even alcohol addiction. The FDA has recognized 3,4-methylenedioxymethamphetamine (MDMA) as a breakthrough therapy to treat symptoms of post-traumatic stress disorder. At the same time, interviews with recreational MDMA users have documented experiences of emotional intimacy while using MDMA, often without the desire for penetrative sex. However, some people have reported that MDMA increases their sexual arousal and specifically use it to enhance their sexual performance. This study aims to analyze current and planned research on the psychophysiological effects of entactogens on human sexuality. With their prosocial potential, the pharmacokinetic and neuroendocrine effects of entactogens may recreate the subjective experience of emotional intimacy, the initiation of intimate relationships, or even feelings of 'falling in love' with previously neutral individuals while under the influence of entactogens. This includes MDMA-induced sexual arousal-like effects observed through subjective behavioral perceptions of desire and arousal and specific physiological markers such as oxytocin and prolactin. Modern MDMA-assisted psychotherapy (MDMA-AP) protocols are transparent and follow strict ethical guidelines. However, despite these proposed ethical principles, little consideration has been given to the potential neurobehavioral effects of entactogens on the sexuality of participants in MDMA-AP protocols. The psychophysiological and sexual effects of entactogens should be discussed more openly in current MDMA-AP protocols, including the potential experience of the phenomenon of sexualized pharmacotransference.
Identifiants
pubmed: 37935915
doi: 10.1007/s43440-023-00552-7
pii: 10.1007/s43440-023-00552-7
pmc: PMC10661745
doi:
Substances chimiques
N-Methyl-3,4-methylenedioxyamphetamine
KE1SEN21RM
Hallucinogens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1381-1397Informations de copyright
© 2023. The Author(s).
Références
Neuropsychopharmacology. 2020 Jan;45(1):217-239
pubmed: 31391575
J Psychopharmacol. 2018 Dec;32(12):1295-1307
pubmed: 30371148
Soc Cogn Affect Neurosci. 2014 Aug;9(8):1076-81
pubmed: 24682132
J Psychoactive Drugs. 1998 Oct-Dec;30(4):371-9
pubmed: 9924843
Focus (Am Psychiatr Publ). 2023 Jul;21(3):306-314
pubmed: 37404974
J Sex Med. 2019 May;16(5):721-732
pubmed: 30952548
Neuropsychopharmacology. 2017 Oct;42(11):2105-2113
pubmed: 28443617
Subst Use Misuse. 2005;40(9-10):1461-77
pubmed: 16048828
Front Psychiatry. 2022 Apr 25;13:863552
pubmed: 35546928
J Psychopharmacol. 2008 Aug;22(6):603-20
pubmed: 18593734
BMJ. 2023 Jul 11;382:1599
pubmed: 37433614
Neuropharmacology. 2023 Sep 15;236:109610
pubmed: 37247807
Braz J Psychiatry. 2021 Mar-Apr;43(2):181-185
pubmed: 32638920
Front Psychol. 2022 Jun 10;13:887255
pubmed: 35756295
Psychopharmacology (Berl). 2019 Sep;236(9):2735-2745
pubmed: 31065731
Med Hypotheses. 2005;64(5):899-903
pubmed: 15780482
Pharmacol Rev. 2016 Apr;68(2):264-355
pubmed: 26841800
J Psychoactive Drugs. 1986 Oct-Dec;18(4):319-27
pubmed: 2880946
Psychiatry (Edgmont). 2007 Apr;4(4):47-50
pubmed: 20711328
Sci Rep. 2021 Oct 25;11(1):21004
pubmed: 34697392
Arch Gen Psychiatry. 1978 Mar;35(3):294-302
pubmed: 365121
Neuropsychopharmacology. 2020 Feb;45(3):462-471
pubmed: 31733631
Nature. 2023 Jul;619(7969):227-228
pubmed: 37386185
J Sex Marital Ther. 2000 Jan-Mar;26(1):25-40
pubmed: 10693114
JAMA. 1970 Jun 15;212(11):1856-63
pubmed: 5467681
Behav Brain Res. 1996;73(1-2):103-7
pubmed: 8788485
Front Psychol. 2020 Jul 10;11:1681
pubmed: 32754101
Biol Psychiatry. 2010 Dec 15;68(12):1134-40
pubmed: 20947066
J Psychopharmacol. 2013 Jan;27(1):40-52
pubmed: 23118021
Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 Jul 17;:
pubmed: 37459910
J Psychoactive Drugs. 1986 Oct-Dec;18(4):355-9
pubmed: 2880951
Horm Behav. 2001 Sep;40(2):291-321
pubmed: 11534994
Nervenarzt. 2006 Jan;77(1):95-6, 98-9
pubmed: 16397805
Med Hypotheses. 1997 May;48(5):399-402
pubmed: 9185125
Eur Neuropsychopharmacol. 2015 Jan;25(1):17-25
pubmed: 25498417
Psychopharmacology (Berl). 2006 Aug;187(3):268-83; discussion 284-92
pubmed: 16826400
J Psychopharmacol. 2011 Apr;25(4):439-52
pubmed: 20643699
Harm Reduct J. 2023 Apr 16;20(1):52
pubmed: 37062840
Cult Health Sex. 2018 Oct;20(10):1071-1086
pubmed: 29909744
Lancet Diabetes Endocrinol. 2023 Jul;11(7):454-464
pubmed: 37192642
Annu Rev Sex Res. 2003;14:1-63
pubmed: 15287157
J Psychopharmacol. 2016 Dec;30(12):1248-1258
pubmed: 27562198
Psychopharmacology (Berl). 2001 Mar 1;154(2):161-8
pubmed: 11314678
J Psychoactive Drugs. 2008 Sep;40(3):225-36
pubmed: 19004414
J Psychopharmacol. 2022 Mar;36(3):252-257
pubmed: 33944625
Pharmacol Biochem Behav. 1991 Mar;38(3):505-12
pubmed: 1829838
Eur Neuropsychopharmacol. 2023 May;70:19-20
pubmed: 36806884
Front Psychiatry. 2022 Mar 25;13:863088
pubmed: 35401275
J Urban Health. 2006 Sep;83(5):884-95
pubmed: 16937088
Clin Pharmacol Ther. 2017 Feb;101(2):209-219
pubmed: 28019026
Socioaffect Neurosci Psychol. 2016 Oct 25;6:31815
pubmed: 27799080
J Psychopharmacol. 2011 Nov;25(11):1453-61
pubmed: 21956378
J Psychopharmacol. 2013 Jan;27(1):28-39
pubmed: 23172889
Cult Med Psychiatry. 2023 Mar;47(1):252-270
pubmed: 35031922
Sex Med. 2021 Aug;9(4):100370
pubmed: 34118520
J Psychopharmacol. 2006 Sep;20(5):670-82
pubmed: 16401654
Ther Drug Monit. 2002 Apr;24(2):277-89
pubmed: 11897973
Clin Pharmacol Ther. 2017 Feb;101(2):194-196
pubmed: 27859039
Psychol Sex. 2018;9(1):54-68
pubmed: 29430277
Eur Psychiatry. 2001 Mar;16(2):127-30
pubmed: 11311178