Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.

Humans Arthritis, Rheumatoid / complications Cytokines / metabolism Inflammation / complications Synovial Membrane / pathology T-Lymphocytes / immunology B-Lymphocytes / immunology Genetic Predisposition to Disease / genetics Phenotype Single-Cell Gene Expression Analysis

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
Nov 2023
Historique:
received: 21 02 2022
accepted: 03 10 2023
medline: 17 11 2023
pubmed: 8 11 2023
entrez: 8 11 2023
Statut: ppublish

Résumé

Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation and destruction

Identifiants

DOI: 10.1038/s41586-023-06708-y PMID: 37938773 PMC: PMC10651487
pubmed: 37938773
doi: 10.1038/s41586-023-06708-y
pii: 10.1038/s41586-023-06708-y
pmc: PMC10651487
doi:

Substances chimiques

Cytokines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

616-624

Subventions

Organisme : NIAMS NIH HHS
ID : UH2 AR067685
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067681
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067689
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067694
Pays : United States
Organisme : NIAMS NIH HHS
ID : K08 AR077037
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148435
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067679
Pays : United States
Organisme : NIAMS NIH HHS
ID : UM2 AR067678
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR069655
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR071670
Pays : United States
Organisme : NIAMS NIH HHS
ID : K08 AR081412
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR007258
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073290
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG002295
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007753
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR007530
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073833
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067688
Pays : United States
Organisme : NIAMS NIH HHS
ID : K08 AR072791
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR063759
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067690
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009379
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067677
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067676
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067691
Pays : United States

Investigateurs

Jennifer Albrecht (J)
Jennifer L Barnas (JL)
Joan M Bathon (JM)
David L Boyle (DL)
S Louis Bridges (SL)
Debbie Campbell (D)
Hayley L Carr (HL)
Adam Chicoine (A)
Andrew Cordle (A)
Patrick Dunn (P)
Lindsy Forbess (L)
Peter K Gregersen (PK)
Joel M Guthridge (JM)
Lionel B Ivashkiv (LB)
Kazuyoshi Ishigaki (K)
Judith A James (JA)
Gregory Keras (G)
Ilya Korsunsky (I)
Amit Lakhanpal (A)
James A Lederer (JA)
Zhihan J Li (ZJ)
Yuhong Li (Y)
Andrew McDavid (A)
Mandy J McGeachy (MJ)
Karim Raza (K)
Yakir Reshef (Y)
Christopher Ritchlin (C)
William H Robinson (WH)
Saori Sakaue (S)
Jennifer A Seifert (JA)
Anvita Singaraju (A)
Melanie H Smith (MH)
Dagmar Scheel-Toellner (D)
Paul J Utz (PJ)
Michael H Weisman (MH)
Aaron Wyse (A)
Zhu Zhu (Z)

Informations de copyright

© 2023. The Author(s).

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Auteurs

Fan Zhang (F)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Rheumatology and the Center for Health Artificial Intelligence, University of Colorado School of Medicine, Aurora, CO, USA.
ORCID: 0000-0002-6102-2970

Anna Helena Jonsson (AH)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA.
ORCID: 0000-0002-9558-2474

Aparna Nathan (A)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Nghia Millard (N)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Michelle Curtis (M)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-6843-4839

Qian Xiao (Q)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Maria Gutierrez-Arcelus (M)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Immunology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-7898-7691

William Apruzzese (W)

Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Bethesda, MD, USA.

Gerald F M Watts (GFM)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Dana Weisenfeld (D)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Saba Nayar (S)

Rheumatology Research Group, Institute for Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK.

Javier Rangel-Moreno (J)

Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.
ORCID: 0000-0002-9738-1182

Nida Meednu (N)

Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.

Kathryne E Marks (KE)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-1524-7159

Ian Mantel (I)

Hospital for Special Surgery, New York, NY, USA.
Weill Cornell Medicine, New York, NY, USA.

Joyce B Kang (JB)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Laurie Rumker (L)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Joseph Mears (J)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Kamil Slowikowski (K)

Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital (MGH), Boston, MA, USA.
ORCID: 0000-0002-2843-6370

Kathryn Weinand (K)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Dana E Orange (DE)

Hospital for Special Surgery, New York, NY, USA.
Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-9859-7199

Laura Geraldino-Pardilla (L)

Division of Rheumatology, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Kevin D Deane (KD)

Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA.
ORCID: 0000-0003-2211-4861

Darren Tabechian (D)

Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.

Arnoldas Ceponis (A)

Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, USA.

Gary S Firestein (GS)

Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0003-3495-960X

Mark Maybury (M)

Rheumatology Research Group, Institute for Inflammation and Ageing, University of Birmingham, Birmingham, UK.
NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.
ORCID: 0000-0002-5031-1064

Ilfita Sahbudin (I)

Rheumatology Research Group, Institute for Inflammation and Ageing, University of Birmingham, Birmingham, UK.
NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.
ORCID: 0000-0003-0702-4403

Ami Ben-Artzi (A)

Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Arthur M Mandelin (AM)

Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Alessandra Nerviani (A)

Centre for Experimental Medicine and Rheumatology, EULAR Centre of Excellence, William Harvey Research Institute, Queen Mary University of London, London, UK.
Barts Health NHS Trust, Barts Biomedical Research Centre (BRC), National Institute for Health and Care Research (NIHR), London, UK.
ORCID: 0000-0003-4064-4014

Myles J Lewis (MJ)

Centre for Experimental Medicine and Rheumatology, EULAR Centre of Excellence, William Harvey Research Institute, Queen Mary University of London, London, UK.
Barts Health NHS Trust, Barts Biomedical Research Centre (BRC), National Institute for Health and Care Research (NIHR), London, UK.
ORCID: 0000-0001-9365-5345

Felice Rivellese (F)

Centre for Experimental Medicine and Rheumatology, EULAR Centre of Excellence, William Harvey Research Institute, Queen Mary University of London, London, UK.
Barts Health NHS Trust, Barts Biomedical Research Centre (BRC), National Institute for Health and Care Research (NIHR), London, UK.
ORCID: 0000-0002-6759-7521

Costantino Pitzalis (C)

Centre for Experimental Medicine and Rheumatology, EULAR Centre of Excellence, William Harvey Research Institute, Queen Mary University of London, London, UK.
Barts Health NHS Trust, Barts Biomedical Research Centre (BRC), National Institute for Health and Care Research (NIHR), London, UK.
Department of Biomedical Sciences, Humanitas University and Humanitas Research Hospital, Milan, Italy.
ORCID: 0000-0003-1326-5051

Laura B Hughes (LB)

Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Diane Horowitz (D)

Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, NY, USA.

Edward DiCarlo (E)

Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY, USA.

Ellen M Gravallese (EM)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Brendan F Boyce (BF)

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
ORCID: 0000-0002-3587-4854

Larry W Moreland (LW)

Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA.
Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Susan M Goodman (SM)

Hospital for Special Surgery, New York, NY, USA.
Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-1197-7864

Harris Perlman (H)

Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

V Michael Holers (VM)

Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, USA.

Katherine P Liao (KP)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-4797-3200

Andrew Filer (A)

Rheumatology Research Group, Institute for Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK.
NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.
ORCID: 0000-0001-8164-6249

Vivian P Bykerk (VP)

Hospital for Special Surgery, New York, NY, USA.
Weill Cornell Medicine, New York, NY, USA.

Kevin Wei (K)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-1821-167X

Deepak A Rao (DA)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-9672-7746

Laura T Donlin (LT)

Hospital for Special Surgery, New York, NY, USA.
Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-1428-090X

Jennifer H Anolik (JH)

Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA.

Michael B Brenner (MB)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-6202-8445

Soumya Raychaudhuri (S)

Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA. soumya@broadinstitute.org.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Broad Institute of MIT and Harvard, Cambridge, MA, USA. soumya@broadinstitute.org.
ORCID: 0000-0002-1901-8265

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Deconstruction of rheumatoid arthritis...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Deconstruction of rheumatoid arthritis...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Deconstruction of rheumatoid arthritis...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Deconstruction of rheumatoid arthritis...
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Capsule articulaire › Membrane synoviale › Deconstruction of rheumatoid arthritis...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Deconstruction of rheumatoid arthritis...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Deconstruction of rheumatoid arthritis...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Deconstruction of rheumatoid arthritis...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Deconstruction of rheumatoid arthritis...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Analyse de l'expression du gène de la cellule unique › Deconstruction of rheumatoid arthritis...