Complement factor H Y402H polymorphism results in diminishing CD4
Aged
Mice
Animals
Humans
C-Reactive Protein
/ metabolism
Complement Factor H
/ genetics
CD8-Positive T-Lymphocytes
/ metabolism
Angiogenesis Inhibitors
Polymorphism, Single Nucleotide
Mice, Inbred C57BL
Visual Acuity
Vascular Endothelial Growth Factor A
/ genetics
Wet Macular Degeneration
Genotype
CD4-Positive T-Lymphocytes
/ metabolism
Case-Control Studies
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 11 2023
08 11 2023
Historique:
received:
10
08
2023
accepted:
06
11
2023
medline:
10
11
2023
pubmed:
9
11
2023
entrez:
8
11
2023
Statut:
epublish
Résumé
Age-related macular degeneration (AMD) is a common cause of visual loss among the elderly. Genetic variants in the gene encoding complement factor H (CFH) have been identified as an AMD susceptibility gene, however, the mechanistic link is debated. Here, we investigated the link between the CFH Y402H genotype and low-grade inflammation. We recruited 153 healthy individuals, 84 participants with dry stages of AMD, and 148 participants with neovascular AMD. All participants were subjected to detailed retinal examination, and interview regarding comorbidities and lifestyle. Blood samples were analyzed for level of C-Reactive Protein (CRP), white blood cell differential count, and stained with fluorescent antibodies to differentiate CD4
Identifiants
pubmed: 37940659
doi: 10.1038/s41598-023-46827-0
pii: 10.1038/s41598-023-46827-0
pmc: PMC10632322
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
Complement Factor H
80295-65-4
Angiogenesis Inhibitors
0
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19414Informations de copyright
© 2023. The Author(s).
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