Can we achieve better trial recruitment by presenting patient information through multimedia? Meta-analysis of 'studies within a trial' (SWATs).

Humans Multimedia Patient Selection Research Design Odds Ratio
Information Meta-analysis Randomised controlled trial Recruitment Research methodology SWATs User testing

Journal

BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723

Informations de publication

Date de publication:
08 Nov 2023
Historique:
received: 12 06 2023
accepted: 14 09 2023
medline: 10 11 2023
pubmed: 9 11 2023
entrez: 8 11 2023
Statut: epublish

Résumé

People need high-quality information to make decisions about research participation. Providing information in written format alone is conventional but may not be the most effective and acceptable approach. We developed a structure for the presentation of information using multimedia which included generic and trial-specific content. Our aim was to embed 'Studies Within A Trial' (SWATs) across multiple ongoing trials to test whether multimedia presentation of patient information led to better rates of recruitment. Five trials included a SWAT and randomised their participants to receive a multimedia presentation alongside standard information, or standard written information alone. We collected data on trial recruitment, acceptance and retention and analysed the pooled results using random effects meta-analysis, with the primary outcome defined as the proportion of participants randomised following an invitation to take part. Five SWATs provided data on the primary outcome of proportion of participants randomised. Multimedia alongside written information results in little or no difference in recruitment rates (pooled odds ratio = 0.96, 95% CI: 0.79 to 1.17, p-value = 0.671, I Multimedia alongside written information did not improve trial recruitment rates. ISRCTN71952900, ISRCTN 06710391, ISRCTN 17160087, ISRCTN05926847, ISRCTN62869767.

Sections du résumé

BACKGROUND BACKGROUND
People need high-quality information to make decisions about research participation. Providing information in written format alone is conventional but may not be the most effective and acceptable approach. We developed a structure for the presentation of information using multimedia which included generic and trial-specific content. Our aim was to embed 'Studies Within A Trial' (SWATs) across multiple ongoing trials to test whether multimedia presentation of patient information led to better rates of recruitment.
METHODS METHODS
Five trials included a SWAT and randomised their participants to receive a multimedia presentation alongside standard information, or standard written information alone. We collected data on trial recruitment, acceptance and retention and analysed the pooled results using random effects meta-analysis, with the primary outcome defined as the proportion of participants randomised following an invitation to take part.
RESULTS RESULTS
Five SWATs provided data on the primary outcome of proportion of participants randomised. Multimedia alongside written information results in little or no difference in recruitment rates (pooled odds ratio = 0.96, 95% CI: 0.79 to 1.17, p-value = 0.671, I
CONCLUSIONS CONCLUSIONS
Multimedia alongside written information did not improve trial recruitment rates.
TRIAL REGISTRATION BACKGROUND
ISRCTN71952900, ISRCTN 06710391, ISRCTN 17160087, ISRCTN05926847, ISRCTN62869767.

Identifiants

DOI: 10.1186/s12916-023-03081-5 PMID: 37940944 PMC: PMC10634086
pubmed: 37940944
doi: 10.1186/s12916-023-03081-5
pii: 10.1186/s12916-023-03081-5
pmc: PMC10634086
doi:

Types de publication

Meta-Analysis Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

425

Subventions

Organisme : Medical Research Council
ID : G1002325
Pays : United Kingdom

Informations de copyright

© 2023. The Author(s).

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Auteurs

Vichithranie W Madurasinghe (VW)

Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7LF, UK.

Peter Knapp (P)

Department of Health Sciences, University of York & the Hull York Medical School, York, YO10 5DD, UK.

Sandra Eldridge (S)

Centre for Clinical Trials and Methodology, Institute of Population Health Sciences, Queen Mary University of London, 58 Turner Street, London, E1 2AB, UK.

David Collier (D)

Barts NIHR Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

Shaun Treweek (S)

Health Services Research Unit, University of Aberdeen, 3Rd Floor, Health Sciences Building, Foresterhill, Aberdeen, AB25 2ZD, UK.

Jo Rick (J)

National Institute of Health Research School for Primary Care Research, Manchester Academic Health Science Centre, Centre for Primary Care, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Jonathan Graffy (J)

General Practitioner Arbury Road Surgery 114, Arbury Road, Cambridge, CB4 2JG, UK.

Adwoa Parker (A)

York Trials Unit, Department of Health Sciences, University of York, York, YO10 5DD, UK.

Chris Salisbury (C)

Centre for Academic Primary Care, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.

David Torgerson (D)

Department of Health Sciences, University of York, Heslington, York, YO10 5DD, UK.

Kate Jolly (K)

Institute of Applied Health Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Manbinder S Sidhu (MS)

Health Services Management Centre, School of Social Policy, University of Birmingham, Edgbaston, Birmingham, B15 2RT, UK.

Christopher Fife-Schaw (C)

University of Surrey, Guildford, UK.

Mark A Hull (MA)

Leeds Institute of Medical Research, University of Leeds, Leeds, LS9 7TF, UK.

Kirsty Sprange (K)

Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, NG7 2RD, UK.

Elizabeth Brettell (E)

Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, B15 2TT, UK.

Sunil Bhandari (S)

Department of Renal Medicine, Hull University Teaching Hospitals NHS Trust, and Hull York Medical School, Hull, East Yorkshire, HU3 2JZ, UK.

Alan Montgomery (A)

Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, NG7 2RD, UK.

Peter Bower (P)

NIHR School for Primary Care Research, School of Health Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PL, UK. peter.bower@manchester.ac.uk.
ORCID: 0000-0001-9558-3349

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Can we achieve better trial recruitment by...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Moyens de communication › Matériel d'enseignement › Supports audiovisuels › Multimédia › Can we achieve better trial recruitment by...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Sélection de patients › Can we achieve better trial recruitment by...
questionsmedicales.fr › Disciplines des sciences naturelles › Science › Recherche › Plan de recherche › Can we achieve better trial recruitment by...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Odds ratio › Can we achieve better trial recruitment by...