Insulin-like growth factors and aging: lessons from Laron syndrome.
IGF1 receptor
Laron syndrome
aging
growth hormone (GH)
insulin-like growth factor-1 (IGF1)
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
09
2023
accepted:
10
10
2023
medline:
10
11
2023
pubmed:
9
11
2023
entrez:
9
11
2023
Statut:
epublish
Résumé
The growth hormone (GH)-insulin-like growth factor-1 (IGF1) signaling pathway emerged in recent years as a key determinant of aging and longevity. Disruption of this network in different animal species, including flies, nematodes and mouse, was consistently associated with an extended lifespan. Epidemiological analyses have shown that patients with Laron syndrome (LS), the best-characterized disease under the umbrella of the congenital IGF1 deficiencies, seem to be protected from cancer. While aging and cancer, as a rule, are considered diametrically opposite processes, modern lines of evidence reinforce the notion that aging and cancer might, as a matter of fact, be regarded as divergent manifestations of identical biochemical and cellular underlying processes. While the effect of individual mutations on lifespan and health span is very difficult to assess, genome-wide screenings identified a number of differentially represented aging- and longevity-associated genes in patients with LS. The present review summarizes recent data that emerged from comprehensive analyses of LS patients and portrays a number of previously unrecognized targets for GH-IGF1 action. Our article sheds light on complex aging and longevity processes, with a particular emphasis on the role of the GH-IGF1 network in these mechanisms.
Identifiants
pubmed: 37941907
doi: 10.3389/fendo.2023.1291812
pmc: PMC10628706
doi:
Substances chimiques
Growth Hormone
9002-72-6
Human Growth Hormone
12629-01-5
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1291812Informations de copyright
Copyright © 2023 Werner and Laron.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Références
J Lab Clin Med. 1957 Jun;49(6):825-36
pubmed: 13429201
Ann Med. 2008;40(3):197-208
pubmed: 18382885
Aging Cell. 2021 Sep;20(9):e13443
pubmed: 34363732
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1045-1050
pubmed: 29339473
Cells. 2022 Oct 17;11(20):
pubmed: 36291127
Mol Cells. 2016 Feb;39(2):87-95
pubmed: 26831453
Horm Metab Res. 2003 Nov-Dec;35(11-12):740-50
pubmed: 14710353
Front Endocrinol (Lausanne). 2015 Jul 03;6:106
pubmed: 26191041
J Clin Endocrinol Metab. 2011 Sep;96(9):2912-20
pubmed: 21795450
J Clin Endocrinol Metab. 2008 Nov;93(11):4210-7
pubmed: 18782877
Biochem Biophys Res Commun. 2018 Apr 6;498(3):566-572
pubmed: 29524408
Isr J Med Sci. 1966 Mar-Apr;2(2):152-5
pubmed: 5916640
Sci Rep. 2018 May 31;8(1):8465
pubmed: 29855513
J Clin Endocrinol Metab. 2014 Feb;99(2):602-8
pubmed: 24285677
Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):302-10
pubmed: 17315038
Endocr Relat Cancer. 2016 May;23(5):399-410
pubmed: 27090428
Front Endocrinol (Lausanne). 2015 Apr 27;6:64
pubmed: 25964779
J Bone Miner Res. 2004 Dec;19(12):2057-64
pubmed: 15537450
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Mutat Res Rev Mutat Res. 2017 Apr - Jun;772:123-133
pubmed: 28528685
Target Oncol. 2017 Oct;12(5):571-597
pubmed: 28815409
Nat Commun. 2019 Dec 2;10(1):5495
pubmed: 31792199
J Biol Chem. 2008 Jan 25;283(4):2397-406
pubmed: 17998203
Nat Rev Cancer. 2008 Dec;8(12):915-28
pubmed: 19029956
J Cell Physiol. 2013 Apr;228(4):675-9
pubmed: 22926508
Science. 1998 Jan 23;279(5350):563-6
pubmed: 9438850
J Mol Endocrinol. 2018 Jul;61(1):T115-T137
pubmed: 29626053
Age (Dordr). 2013 Feb;35(1):235-49
pubmed: 22113349
Circ Res. 2005 Sep 2;97(5):411-4
pubmed: 16141115
Growth Horm IGF Res. 2005 Jul;15 Suppl A:S3-5
pubmed: 16023877
EMBO Mol Med. 2016 Mar 31;8(4):363-74
pubmed: 26902202
J Clin Endocrinol Metab. 2009 May;94(5):1732-9
pubmed: 19223521
Genes Cancer. 2010 Sep;1(9):893-907
pubmed: 21779470
Endocr Pract. 2015 Dec;21(12):1395-402
pubmed: 26401581
Cell. 2001 Apr 20;105(2):165-8
pubmed: 11336665
Science. 2008 Mar 28;319(5871):1785-6
pubmed: 18369135
Cells. 2021 Jul 22;10(8):
pubmed: 34440625
N Engl J Med. 2003 Sep 18;349(12):1139-47
pubmed: 13679528
N Engl J Med. 2003 Dec 4;349(23):2184-6
pubmed: 14657423
Lancet. 1998 May 9;351(9113):1393-6
pubmed: 9593409
Cancer Treat Rev. 2014 Oct;40(9):1096-105
pubmed: 25123819
EMBO Mol Med. 2019 Dec;11(12):e10234
pubmed: 31746100
J Clin Endocrinol Metab. 2023 May 17;108(6):1355-1369
pubmed: 36546343
J Clin Endocrinol Metab. 2004 Mar;89(3):1031-44
pubmed: 15001582
Cells. 2019 Jun 15;8(6):
pubmed: 31208077
Pediatr Endocrinol Rev. 2018 Sep;16(Suppl 1):39-62
pubmed: 30378782
Cell Metab. 2016 Jun 14;23(6):980-989
pubmed: 27304500
Proc Natl Acad Sci U S A. 1989 Oct;86(20):8083-7
pubmed: 2813379
Biochem J. 2010 Nov 15;432(1):199-205
pubmed: 20819078
Pediatr Endocrinol Rev. 2006 Aug;3 Suppl 3:489-97
pubmed: 17551471
Trends Endocrinol Metab. 2008 Aug;19(6):197-205
pubmed: 18515143
Eur J Endocrinol. 2011 Apr;164(4):485-9
pubmed: 21292919
Lancet. 2004 Apr 24;363(9418):1346-53
pubmed: 15110491
J Biol Chem. 2006 Aug 4;281(31):21884-21891
pubmed: 16766796
N Engl J Med. 1996 Oct 31;335(18):1363-7
pubmed: 8857020
Science. 2001 Apr 6;292(5514):104-6
pubmed: 11292874
Endocrinology. 2000 Jul;141(7):2608-13
pubmed: 10875265
Novartis Found Symp. 2002;242:125-37; discussion 137-42
pubmed: 11855684
J Clin Endocrinol Metab. 2023 Jul 14;108(8):1835-1874
pubmed: 37326526
Mol Endocrinol. 2009 Nov;23(11):1876-84
pubmed: 19819989
J Biol Chem. 2011 Aug 19;286(33):29139-29145
pubmed: 21705327
Exp Gerontol. 2005 Nov;40(11):867-72
pubmed: 16154307
J Am Geriatr Soc. 2017 Oct;65(10):2297-2301
pubmed: 28869295
Diabetes. 2012 Jun;61(6):1315-22
pubmed: 22618766
Isr Med Assoc J. 2017 Jan;19(1):6-7
pubmed: 28457105
Science. 1997 Aug 15;277(5328):942-6
pubmed: 9252323
Pediatr Endocrinol Rev. 2011 Jun;8(4):354-62; quiz 362-3
pubmed: 21972775
Cancer Res. 2003 Jan 15;63(2):432-40
pubmed: 12543799
J Clin Invest. 2015 Aug 3;125(8):3008-26
pubmed: 26121747
Mol Cell Endocrinol. 2020 Dec 1;518:111003
pubmed: 32919021
Front Oncol. 2022 Nov 21;12:1055589
pubmed: 36479090
Cells. 2021 Aug 12;10(8):
pubmed: 34440832
N Engl J Med. 1989 Oct 12;321(15):989-95
pubmed: 2779634
J Alzheimers Dis. 2021;82(1):149-157
pubmed: 33998544
Oncogene. 2011 Dec 8;30(49):4910-20
pubmed: 21643012
Cancer Res. 2005 Jun 1;65(11):4485-9
pubmed: 15930262
Br J Pharmacol. 2022 Apr;179(8):1496-1511
pubmed: 34029375
N Engl J Med. 2004 Feb 5;350(6):570-7
pubmed: 14762184
Baillieres Clin Endocrinol Metab. 1998 Jul;12(2):281-96
pubmed: 10083897
Cells. 2020 Nov 09;9(11):
pubmed: 33182502
Curr Neuropharmacol. 2021;19(7):1019-1037
pubmed: 32727328
Aging Cell. 2014 Aug;13(4):669-78
pubmed: 25070626
Int J Biochem Cell Biol. 2011 Dec;43(12):1668-73
pubmed: 21964212