Autoimmune Hepatitis: Pathophysiology.

Humans Hepatitis, Autoimmune Genome-Wide Association Study Autoimmunity Immunosuppressive Agents
Autoantibodies Autoimmune hepatitis Autoimmunity Immune regulation Microbiome Molecular mimicry T cells

Journal

Clinics in liver disease
ISSN: 1557-8224
Titre abrégé: Clin Liver Dis
Pays: United States
ID NLM: 9710002

Informations de publication

Date de publication:
02 2024
Historique:
medline: 13 11 2023
pubmed: 10 11 2023
entrez: 9 11 2023
Statut: ppublish

Résumé

Genome-wide association analyses suggest that HLA genes including HLA-DRB*0301, HLA-DRB*0401, and HLA-B*3501 as well as non-HLA genes including CD28/CTLA4/ICOS and SYNPR increased AIH susceptibility. The destruction of hepatocytes is the result of the imbalance between proinflammatory cells and immunosuppressive cells, especially the imbalance between Tregs and Th17 cells. The microbiome in patients with AIH is decreased in diversity with a specific decline in Bifidobacterium and enrichment in Veillonella and Faecalibacterium. Recent evidence has demonstrated the pathogenic role of E. gallinarum and L.reuteri in inducing autoimmunity in the liver.

Identifiants

DOI: 10.1016/j.cld.2023.06.003 PMID: 37945156
pubmed: 37945156
pii: S1089-3261(23)00077-6
doi: 10.1016/j.cld.2023.06.003
pii:
doi:

Substances chimiques

Immunosuppressive Agents 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15-35

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Zhou Yuming (Z)

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai, China.

Tang Ruqi (T)

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai, China.

Merrill Eric Gershwin (ME)

Division of Rheumatology, Department of Medicine, Allergy and Clinical Immunology, University of California at Davis, 451 Health Sciences Drive, Suite 6510, Davis, CA 95616, USA. Electronic address: megershwin@ucdavis.edu.

Ma Xiong (M)

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai, China; Institute of Aging & Tissue Regeneration, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: maxiongmd@hotmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Autoimmune Hepatitis: Pathophysiology.
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Hépatite auto-immune › Autoimmune Hepatitis: Pathophysiology.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Autoimmune Hepatitis: Pathophysiology.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › Autoimmune Hepatitis: Pathophysiology.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › Autoimmune Hepatitis: Pathophysiology.