Characterizing microstructural development in the fetal brain using diffusion MRI from 23 to 36 weeks of gestation.
diffusion tensor imaging
fetal brain
in vivo imaging
normal development
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
14 Jan 2024
14 Jan 2024
Historique:
received:
30
08
2023
revised:
09
10
2023
accepted:
10
10
2023
pmc-release:
08
11
2024
medline:
19
1
2024
pubmed:
10
11
2023
entrez:
10
11
2023
Statut:
ppublish
Résumé
We utilized motion-corrected diffusion tensor imaging (DTI) to evaluate microstructural changes in healthy fetal brains during the late second and third trimesters. Data were derived from fetal magnetic resonance imaging scans conducted as part of a prospective study spanning from 2013 March to 2019 May. The study included 44 fetuses between the gestational ages (GAs) of 23 and 36 weeks. We reconstructed fetal brain DTI using a motion-tracked slice-to-volume registration framework. Images were segmented into 14 regions of interest (ROIs) through label propagation using a fetal DTI atlas, with expert refinement. Statistical analysis involved assessing changes in fractional anisotropy (FA) and mean diffusivity (MD) throughout gestation using mixed-effects models, and identifying points of change in trajectory for ROIs with nonlinear trends. Results showed significant GA-related changes in FA and MD in all ROIs except in the thalamus' FA and corpus callosum's MD. Hemispheric asymmetries were found in the FA of the periventricular white matter (pvWM), intermediate zone, and subplate and in the MD of the ganglionic eminence and pvWM. This study provides valuable insight into the normal patterns of development of MD and FA in the fetal brain. These changes are closely linked with cytoarchitectonic changes and display indications of early functional specialization.
Identifiants
pubmed: 37948665
pii: 7381652
doi: 10.1093/cercor/bhad409
pmc: PMC10793585
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : R01 HD109395
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
Organisme : NIH HHS
ID : S10 OD025111
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS121657
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB019483
Pays : United States
Organisme : NLM NIH HHS
ID : R01 LM013608
Pays : United States
Organisme : NIH HHS
ID : R01 HD1093950
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106030
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB018988
Pays : United States
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Radiographics. 2023 Apr;43(4):e220141
pubmed: 36995947
Neuroimage. 2019 Mar;188:743-773
pubmed: 30594683
Neuroimage. 2019 Jan 15;185:685-698
pubmed: 29959046
Neuroimage. 2017 Nov 15;162:65-72
pubmed: 28801253
JAMA Netw Open. 2021 Mar 1;4(3):e213526
pubmed: 33779746
J Neurosci. 2009 Apr 1;29(13):4263-73
pubmed: 19339620
Neuroimage. 2017 Aug 1;156:475-488
pubmed: 28433624
Proc Natl Acad Sci U S A. 2021 May 18;118(20):
pubmed: 33972435
Cereb Cortex. 2002 Dec;12(12):1237-43
pubmed: 12427675
J Neuropathol Exp Neurol. 2002 Feb;61(2):197-211
pubmed: 11853021
Radiology. 2021 Feb;298(2):415-424
pubmed: 33289612
IEEE Trans Med Imaging. 2016 Oct;35(10):2258-2269
pubmed: 27834639
Cereb Cortex. 2014 Mar;24(3):579-92
pubmed: 23131806
Pediatr Radiol. 2018 Apr;48(4):486-498
pubmed: 29550863
Neuroimage. 2013 Nov 1;81:335-346
pubmed: 23684865
Neuroimage. 2004 Jul;22(3):1134-40
pubmed: 15219585
AJNR Am J Neuroradiol. 2022 Jul;43(7):1036-1041
pubmed: 35654491
AJNR Am J Neuroradiol. 2011 Feb;32(2):E21-2
pubmed: 20075085
AJNR Am J Neuroradiol. 2010 Jun;31(6):1091-9
pubmed: 20075102
Hum Brain Mapp. 2021 Dec 1;42(17):5771-5784
pubmed: 34487404
Med Image Anal. 2023 Apr;85:102731
pubmed: 36608414
Elife. 2023 Apr 03;12:
pubmed: 37010273
J Anat. 2019 Sep;235(3):670-686
pubmed: 31070791
Hum Brain Mapp. 2023 Mar;44(4):1593-1602
pubmed: 36421003
AJNR Am J Neuroradiol. 2016 Jan;37(1):155-62
pubmed: 26494693
J Neurosci Res. 2005 Jul 15;81(2):172-8
pubmed: 15931676
Neuroimage. 2019 Jan 15;185:593-608
pubmed: 30172006
IEEE Trans Med Imaging. 2007 Nov;26(11):1585-97
pubmed: 18041273
Top Magn Reson Imaging. 2019 Oct;28(5):245-254
pubmed: 31592991
IEEE Trans Med Imaging. 2013 Oct;32(10):1840-52
pubmed: 23744673
J Comput Assist Tomogr. 1995 Jan-Feb;19(1):28-33
pubmed: 7529780
PLoS One. 2015 Mar 05;10(3):e0119536
pubmed: 25742520
Neuroradiology. 2009 Sep;51(9):567-76
pubmed: 19421746
Neuroimaging Clin N Am. 2006 Feb;16(1):19-43, vii
pubmed: 16543084
Cereb Cortex. 2016 Oct 17;26(11):4381-4391
pubmed: 26405055
Neuroimage. 2021 Nov;243:118482
pubmed: 34455242
J Magn Reson. 2006 Sep;182(1):115-25
pubmed: 16828568
Sci Rep. 2017 Mar 28;7(1):476
pubmed: 28352082