Targeted Therapies for Microvascular Disease.

Humans Coronary Circulation Coronary Artery Disease / complications Myocardial Ischemia / drug therapy Myocardium Heart Disease Risk Factors Coronary Vessels
Angina CMD INOCA Ischemia Management

Journal

Cardiology clinics
ISSN: 1558-2264
Titre abrégé: Cardiol Clin
Pays: Netherlands
ID NLM: 8300331

Informations de publication

Date de publication:
Feb 2024
Historique:
medline: 13 11 2023
pubmed: 11 11 2023
entrez: 10 11 2023
Statut: ppublish

Résumé

Coronary microvascular dysfunction (CMD) is a common cause of ischemia but no obstructive coronary artery disease that results in an inability of the coronary microvasculature to meet myocardial oxygen demand. CMD is challenging to diagnose and manage due to a lack of mechanistic research and targeted therapy. Recent evidence suggests we can improved patient outcomes by stratifying antianginal therapies according to the diagnosis revealed by invasive assessment of the coronary microcirculation. This review article appraises the evidence for management of CMD, which includes treatment of cardiovascular risk, antianginal therapy and therapy for atherosclerosis.

Identifiants

DOI: 10.1016/j.ccl.2023.07.002 PMID: 37949535
pubmed: 37949535
pii: S0733-8651(23)00068-1
doi: 10.1016/j.ccl.2023.07.002
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

137-145

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Adam Bland (A)

Department of Cardiology, Gosford Hospital - Central Coast LHD, 75 Holden Street, Gosford, New South Wales 2250, Australia; The University of Newcastle, University Dr, Callaghan, New South Wales 2308, Australia.

Eunice Chuah (E)

Department of Cardiology, Gosford Hospital - Central Coast LHD, 75 Holden Street, Gosford, New South Wales 2250, Australia; The University of Newcastle, University Dr, Callaghan, New South Wales 2308, Australia.

William Meere (W)

Department of Cardiology, Gosford Hospital - Central Coast LHD, 75 Holden Street, Gosford, New South Wales 2250, Australia; The University of Newcastle, University Dr, Callaghan, New South Wales 2308, Australia.

Thomas J Ford (TJ)

Department of Cardiology, Gosford Hospital - Central Coast LHD, 75 Holden Street, Gosford, New South Wales 2250, Australia; The University of Newcastle, University Dr, Callaghan, New South Wales 2308, Australia; University of Glasgow, ICAMS, G12 8QQ Glasgow, UK. Electronic address: Tom.ford@health.nsw.gov.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeted Therapies for Microvascular Disease.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Circulation coronarienne › Targeted Therapies for Microvascular Disease.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Maladie coronarienne › Maladie des artères coronaires › Targeted Therapies for Microvascular Disease.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Targeted Therapies for Microvascular Disease.
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Targeted Therapies for Microvascular Disease.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Facteurs de risque de maladie cardiaque › Targeted Therapies for Microvascular Disease.
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Veines › Vaisseaux coronaires › Targeted Therapies for Microvascular Disease.