Severe, Refractory Seizures: New-Onset Refractory Status Epilepticus and Febrile Infection-Related Epilepsy Syndrome.

Humans Seizures Status Epilepticus / diagnosis Epilepsy / diagnosis Encephalitis Epileptic Syndromes / diagnosis
Epilepsy FIRES NORSE Refractory status epilepticus Seizure

Journal

The Medical clinics of North America
ISSN: 1557-9859
Titre abrégé: Med Clin North Am
Pays: United States
ID NLM: 2985236R

Informations de publication

Date de publication:
Jan 2024
Historique:
medline: 13 11 2023
pubmed: 12 11 2023
entrez: 11 11 2023
Statut: ppublish

Résumé

NORSE (new-onset refractory status epilepticus) and FIRES (febrile infection-related epilepsy syndrome) represent presentations of new-onset status epilepticus without apparent underlying structural, metabolic, or toxic etiology. The cause of NORSE/FIRES remains cryptogenic in up to half of cases, and an abnormal response of the innate immune system has been implicated. Consensus guidelines recommend broad diagnostic investigation and empiric treatment with immunotherapy. NORSE/FIRES is associated with poor outcomes including cognitive impairment and epilepsy, but early recognition and treatment may be important for improving outcomes.

Identifiants

DOI: 10.1016/j.mcna.2023.05.020 PMID: 37951651
pubmed: 37951651
pii: S0025-7125(23)00080-9
doi: 10.1016/j.mcna.2023.05.020
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

201-213

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Ross Carson (R)

Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Coral M Stredny (CM)

Division of Epilepsy and Clinical Neurophysiology, Program in Neuroimmunology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: coral.stredny@childrens.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Severe, Refractory Seizures: New-Onset...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › Severe, Refractory Seizures: New-Onset...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › État de mal épileptique › Severe, Refractory Seizures: New-Onset...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Severe, Refractory Seizures: New-Onset...
questionsmedicales.fr › Maladies du système nerveux › Encéphalite › Severe, Refractory Seizures: New-Onset...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Syndromes épileptiques › Severe, Refractory Seizures: New-Onset...